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Neutron Capture Therapy

Neutron Capture Therapy
Author: Wolfgang A.G. Sauerwein
Publisher: Springer Science & Business Media
Total Pages: 545
Release: 2012-11-05
Genre: Medical
ISBN: 3642313345

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Neutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter, which in principle allows for tumor cell-selective high-LET particle radiotherapy. This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.


Design And Construction Of Accelerator-Based Boron Neutron Capture Therapy Facility With Multiple Treatment Rooms At Southern Tohoku BNCT Research Center

Design And Construction Of Accelerator-Based Boron Neutron Capture Therapy Facility With Multiple Treatment Rooms At Southern Tohoku BNCT Research Center
Author: Takahiro Kato
Publisher:
Total Pages:
Release: 2017
Genre:
ISBN:

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Purpose; To describe the design and construction of an accelerator-based boron neutron capture therapy (AB-BNCT) facility with multiple treatment rooms at the Southern Tohoku BNCT Research Center (STBRC).Materials and Methods; AB-BNCT system at the STBRC is equipped with a cyclotron-based epithermal neutron source (C-BENS), which consists of a cyclotron accelerator (HM-30), a beryllium neutron production target, and a beam shaping assembly (BSA). We developed a remote patient transport system (RPTS) for workers to reduce the work time in the treatment room under the condition of remaining activities just after an irradiation. We studied the feasibility of this system and carefully designed optimum layout to realize patient flow and workflow efficiently.Results; We designed the upside-down Y shaped beamline configuration, in which HM-30 and two treatment rooms are assumed to be located on a top and bottoms, respectively. To reduce the activities caused by thermal neutron, BSA is surrounded by LiF-loaded polyethylene blocks and low-activation concrete. The measured out-of-field thermal and fast neutron dose profiles were in good agreement with calculated ones using MCNPX. It was also confirmed that the RPTS could be operated up to 9 m apart from the RPTS without any problems. Conclusion; We successfully established the environment of BNCT as one of the division of general hospital without sense of incongruity in comparison of environment of conventional radiotherapy. The AB-BNCT system described in this study confirmed to specifications and is being used for BNCT in a hospital.


Frontiers in Neutron Capture Therapy

Frontiers in Neutron Capture Therapy
Author: M. Frederick Hawthorne
Publisher: Springer
Total Pages: 1389
Release: 2013-11-11
Genre: Medical
ISBN: 1461512859

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Frontiers in Neutron Capture Therapy contains current research results originally presented at the Eighth International Symposium on Neutron Capture Therapy for Cancer in La Jolla, CA. This comprehensive collection of peer-reviewed manuscripts is showcased in two volumes covering all aspects of the development of this multidisciplinary approach to cancer therapy. Volume I of this work includes clinical results and current progress in treatment planning, neutron sources and dosimetry, while Volume II presents the synthesis, pharmacology and tissue-targeting design of boron compounds, including work on preclinical dosimetry and radiobiology. Intended for researchers and clinicians involved with or interested in new modes of cancer therapy, this volume will also serve as a useful guideline for scientists, students, and practitioners in the field.


Advances in Neutron Capture Therapy

Advances in Neutron Capture Therapy
Author: Börje Larsson
Publisher:
Total Pages: 640
Release: 1997
Genre: Boron-neutron capture therapy
ISBN:

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Final Report for the "WSU Neutron Capture Therapy Facility Support."

Final Report for the
Author:
Publisher:
Total Pages:
Release: 2006
Genre:
ISBN:

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The objective for the cooperative research program for which this report has been written was to provide separate NCT facility user support for the students, faculty and scientists who would be doing the U.S. Department of Energy Office (DOE) of Science supported advanced radiotargeted research at the WSU 1 megawatt TRIGA reactor. The participants were the Idaho National laboratory (INL, P.I., Dave Nigg), the Veterinary Medical Research Center of Washington State University (WSU, Janean Fidel and Patrick Gavin), and the Washington State University Nuclear Radiation Center (WSU, P.I., Gerald Tripard). A significant number of DOE supported modifications were made to the WSU reactor in order to create an epithermal neutron beam while at the same time maintaining the other activities of the 1 MW reactor. These modifications were: (1) Removal of the old thermal column. (2) Construction and insertion of a new epithermal filter, collimator and shield. (3) Construction of a shielded room that could accommodate the very high radiation field created by an intense neutron beam. (4) Removal of the previous reactor core fuel cluster arrangement. (5) Design and loading of the new reactor core fuel cluster arrangement in order to optimize the neutron flux entering the epithermal neutron filter. (6) The integration of the shielded rooms interlocks and radiological controls into the SCRAM chain and operating electronics of the reactor. (7) Construction of a motorized mechanism for moving and remotely controlling the position of the entire reactor bridge. (8) The integration of the reactor bridge control electronics into the SCRAM chain and operating electronics of the reactor. (9) The design, construction and attachment to the support structure of the reactor of an irradiation box that could be inserted into position next to the face of the reactor. (Necessitated by the previously mentioned core rearrangement). All of the above modifications were successfully completed and tested. The resulting epithermal beam of 1 x 109 n/sec-cm2 was measured by Idaho National Laboratory with assistance from WSU's Neutron Activation Analysis Group. The beam is as good as our initial proposals for the project had predicted. In addition to all of the design, construction and insertion of the hardware, shielding, electronics and radiation monitoring systems there was considerable manpower and effort put into changes in the Technical Specifications of the reactor and implementing procedures for use of the new facility. This staff involvement is one of the reasons we requested special facility support from the DOE. Once the facility was competed and all of the recalibrations and measurements made to characterize the differences between this reactor core and the previous core we began to assist INL in making their beam measurements with foils and phantoms. Although we proposed support for only one additional staff position to support this new NCT facility the staff support provided by the WSU Nuclear Radiation Center was greater than had been anticipated by our initial proposal. INL was also assisted in the testing of a heavy water (deuterated water) bladder that can be inserted into the collimator in order to produce an intense, external thermal neutron beam. The external epithermal and/or thermal neutron beam capability remains available for use, if funding becomes available for future research projects.


Scientific and Technical Aerospace Reports

Scientific and Technical Aerospace Reports
Author:
Publisher:
Total Pages: 538
Release: 1995
Genre: Aeronautics
ISBN:

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Lists citations with abstracts for aerospace related reports obtained from world wide sources and announces documents that have recently been entered into the NASA Scientific and Technical Information Database.


Malignant Gliomas: RMR V3 I2

Malignant Gliomas: RMR V3 I2
Author: Arnab Chakravarti, MD
Publisher: Demos Medical Publishing
Total Pages: 201
Release: 2012-10-09
Genre: Medical
ISBN: 1936287765

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Radiation Medicine Rounds is a trinary, hard cover periodical designed to provide an up-to-date review of a dedicated radiation medicine topic of interest to clinicians and scientists who are involved in the care of patients receiving radiotherapy. It is intended to serve as both a reference and instructional tool for students, housestaff, fellows, practicing clinicians, medical physicists, cancer biologists, radiobiologists, and interdisciplinary colleagues throughout the oncology spectrum. This issue of Radiation Medicine Rounds discusses the more salient topics surrounding the role of radiation therapy for malignant gliomas. The specialty of radiation therapy has increased in complexity over the years, yet as technology improves, the goal of improving outcomes while decreasing toxicity remains critical. Malignant gliomas remain among the most devastating of all malignancies, yet as conventional treatments (surgery, radiation, and chemotherapy) have become optimized overall survival has improved. The underlying molecular and genetic mechanisms of these tumors are becoming better understood, with one of the most important realizations being that histopathologically identical malignant gliomas often demonstrate very distinct clinical behaviors. Malignant Gliomas provides the practitioner with a current overview of best practices, recent research, and future directions in the management of this complex and challenging cancer. "