Mechanisms of Contraction of the Normal and Failing Heart
Author | : Eugene Braunwald |
Publisher | : |
Total Pages | : 0 |
Release | : 1968 |
Genre | : Heart |
ISBN | : |
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Author | : Eugene Braunwald |
Publisher | : |
Total Pages | : 0 |
Release | : 1968 |
Genre | : Heart |
ISBN | : |
Author | : E. V. Braunwald |
Publisher | : |
Total Pages | : |
Release | : 1968 |
Genre | : Heart |
ISBN | : 9780316106856 |
Author | : Eugene Braunwald |
Publisher | : |
Total Pages | : 205 |
Release | : 1968 |
Genre | : Muscle contraction |
ISBN | : |
Author | : R. John Solaro |
Publisher | : Biota Publishing |
Total Pages | : 46 |
Release | : 2011-04-01 |
Genre | : Medical |
ISBN | : 1615041753 |
Contractility describes the relative ability of the heart to eject a stroke volume (SV) at a given prevailing afterload (arterial pressure) and preload (end-diastolic volume; EDV). Various measures of contractility are related to the fraction as the SV/EDV or the ejection fraction, and the dynamics of ejection as determined from maximum pressure rise in the ventricles or arteries or from aortic flow velocities determined by echocardiography. At the cellular level, the ultimate determinant of contractility is the relative tension generation and shortening capability of the molecular motors (myosin cross-bridges) of the sarcomeres as determined by the rates and extent of Ca activation, the turnover kinetics of the cross-bridges, and the relative Ca responsiveness of the sarcomeres. Engagement of the regulatory signaling cascades controlling contractility occurs with occupancy and signal transduction by receptors for neurohumors of the autonomic nervous system as well as growth and stress signaling pathways. Contractility is also determined by the prevailing conditions of pH, temperature, and redox state. Short-term control of contractility is fully expressed during exercise. In long-term responses to stresses on the heart, contractility is modified by cellular remodeling and altered signaling that may compensate for a time but which ultimately may fail, leading to disorders.
Author | : Euan A. Ashley |
Publisher | : Remedica |
Total Pages | : 258 |
Release | : 2004 |
Genre | : Cardiology |
ISBN | : 1901346226 |
One of the most time-consuming tasks in clinical medicine is seeking the opinions of specialist colleagues. There is a pressure not only to make referrals appropriate but also to summarize the case in the language of the specialist. This book explains basic physiologic and pathophysiologic mechanisms of cardiovascular disease in a straightforward manner, gives guidelines as to when referral is appropriate, and, uniquely, explains what the specialist is likely to do. It is ideal for any hospital doctor, generalist, or even senior medical student who may need a cardiology opinion, or for that ma.
Author | : Gianfranco Sinagra |
Publisher | : Springer |
Total Pages | : 241 |
Release | : 2019-05-17 |
Genre | : Medical |
ISBN | : 303013864X |
This open access book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines for its clinical management. The first part of the book analyzes in detail the disease’s pathophysiology, its diagnostic work up as well as the prognostic stratification, and illustrates the role of genetics and gene-environment interaction. The second part presents current and future treatment options, highlighting the importance of long-term and individualized treatments and follow-up. Furthermore, it discusses open issues, such as the apparent healing phenomenon, the early prognosis of arrhythmic events or the use of genetic testing in clinical practice. Offering a multidisciplinary approach for optimizing the clinical management of DCM, this book is an invaluable aid not only for the clinical cardiologists, but for all physicians involved in the care of this challenging disease.
Author | : David C. Warltier |
Publisher | : Lippincott Williams & Wilkins |
Total Pages | : 404 |
Release | : 1995 |
Genre | : Medical |
ISBN | : |
Author | : Michitoshi Inoue |
Publisher | : Springer Science & Business Media |
Total Pages | : 330 |
Release | : 2013-11-09 |
Genre | : Medical |
ISBN | : 4431683674 |
Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.
Author | : Alexandre Mebazaa |
Publisher | : Springer Science & Business Media |
Total Pages | : 922 |
Release | : 2009-12-24 |
Genre | : Medical |
ISBN | : 1846287820 |
For many years, there has been a great deal of work done on chronic congestive heart failure while acute heart failure has been considered a difficult to handle and hopeless syndrome. However, in recent years acute heart failure has become a growing area of study and this is the first book to cover extensively the diagnosis and management of this complex condition. The book reflects the considerable amounts of new data reported and many new concepts which have been proposed in the last 3-4 years looking at the epidemiology, diagnostic and treatment of acute heart failure.
Author | : Naranjan S. Dhalla |
Publisher | : Springer Science & Business Media |
Total Pages | : 578 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 1461312353 |
Pathophysiology of Heart Failure brings together leading basic scientists and clinicians, presenting new approaches to this complex problem, involving cardiomyopathic processes and ischemia perfusion injury. The result is a synthesis of state-of-the-art information on molecular biology, cellular physiology and structure-function relationships in the cardiovascular system. The role which excess intracellular calcium plays in the genesis of cardiac dysfunction is described as a fundamental mechanism underlying heart failure; one which may lead to improved prevention and treatment. Audience: Clinical and experimental cardiologists will find the book a helpful source of ideas and inspiration.