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| Author | : Masahiro Kinoshita |
| Publisher | : Springer |
| Total Pages | : |
| Release | : 2021-02-15 |
| Genre | : Science |
| ISBN | : 9789813362314 |
Download Mechanism of Functional Expression of F1-ATPase Book in PDF, ePub and Kindle
This book presents a new view of the mechanism of functional expression of ATP-driven motors (proteins or protein complexes). It is substantially different from the prevailing idea that the motor converts chemical energy to mechanical work. To facilitate understanding, the differences between the new and prevailing views are explained using many illustrations. The book is of interest to those who are not convinced of the notion of chemo–mechanical coupling. The claims presented are the following: The system, which comprises not only the motor but also water, does no mechanical work during the ATP hydrolysis cycle; a protein is moved or a protein in the complex is rotated by the entropic force generated by water. The highlight of the explanation in the book is that the mechanism of unidirectional rotation of the central shaft in F1-ATPase is discussed in detail on the basis of this new view. The hydration entropy of each β subunit to which a specific chemical compound (ATP, ADP and Pi, Pi, or nothing) is bound, the hydration entropy of the α3β3 complex, and the dependence of the hydration entropy of F1-ATPase on the orientation of the γ subunit play essential roles.
| Author | : Masahiro Kinoshita |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2021 |
| Genre | : |
| ISBN | : 9789813362338 |
Download Mechanism of Functional Expression of F1-ATPase: A New View on Mechanism of Functional Expression of an ATP-Driven Motor Book in PDF, ePub and Kindle
| Author | : Masahiro Kinoshita |
| Publisher | : Springer Nature |
| Total Pages | : 87 |
| Release | : 2020-12-30 |
| Genre | : Science |
| ISBN | : 9813362324 |
Download Mechanism of Functional Expression of F1-ATPase Book in PDF, ePub and Kindle
This book presents a new view of the mechanism of functional expression of ATP-driven motors (proteins or protein complexes). It is substantially different from the prevailing idea that the motor converts chemical energy to mechanical work. To facilitate understanding, the differences between the new and prevailing views are explained using many illustrations. The book is of interest to those who are not convinced of the notion of chemo–mechanical coupling. The claims presented are the following: The system, which comprises not only the motor but also water, does no mechanical work during the ATP hydrolysis cycle; a protein is moved or a protein in the complex is rotated by the entropic force generated by water. The highlight of the explanation in the book is that the mechanism of unidirectional rotation of the central shaft in F1-ATPase is discussed in detail on the basis of this new view. The hydration entropy of each β subunit to which a specific chemical compound (ATP, ADP and Pi, Pi, or nothing) is bound, the hydration entropy of the α3β3 complex, and the dependence of the hydration entropy of F1-ATPase on the orientation of the γ subunit play essential roles.
| Author | : Masahiro Kinoshita |
| Publisher | : Springer |
| Total Pages | : 77 |
| Release | : 2016-06-14 |
| Genre | : Science |
| ISBN | : 9811014868 |
Download Mechanism of Functional Expression of the Molecular Machines Book in PDF, ePub and Kindle
This brief discusses the mechanism of functional expression of a protein or protein complex utilizing the ATP hydrolysis cycle or proton-motive force from a unique point of view focused on the roles of water. A variety of processes are considered such as the unidirectional movement of a linear-motor protein along a filament, insertion of an unfolded protein into a chaperonin and release of the folded protein from it, transport of diverse substrates across the membrane by a transporter, and directed rotation of the central subunit within a rotatory motor protein complex. These topics are discussed in a unified manner within the same theoretical framework. The author argues that water plays imperative roles in the functional expression of these molecular machines. A pivotal factor is the entropic force or potential originating from the translational displacement of water molecules coexisting with the molecular machines in the entire system.
| Author | : Martinus Bernardus Maria van Dongen |
| Publisher | : |
| Total Pages | : 167 |
| Release | : 1987 |
| Genre | : |
| ISBN | : |
Download Nucleotide-binding Sites on the Mitochondrial F1-ATPase: Localization and Function in the Reaction Mechanism of ATP Hydrolysis Book in PDF, ePub and Kindle
| Author | : L. Ernster |
| Publisher | : Elsevier |
| Total Pages | : 543 |
| Release | : 1992-12-16 |
| Genre | : Science |
| ISBN | : 0080860834 |
Download Molecular Mechanisms in Bioenergetics Book in PDF, ePub and Kindle
This book summarises current knowledge of the structure, function,biosynthesis and regulation of energy-transducing enzymes inmitochondria, chloroplasts and bacteria. Each of the twenty chapters is written by top experts in their field, and Prof. Ernster has ensured that the book as a whole gives a well-integrated picture of the present state of knowledge of the field at its different levels and complexities. Since the publication of Bioenergetics edited by Lars Ernster in 1984, (New Comprehensive Biochemistry Vol. 9) the whole field of bioenergetics has undergone a tremendous expansion. Additionally a transition from membrane bioenergetics to molecular bioenergetics has accompanied this expansion - due mainly to the spectacular progress in the field of molecular biology over the past twenty years. Hence this volume, Molecular Mechanisms in Bioenergetics, is certain to be of interest, not only to the specialist in bioenergetics, but also to researchers working in the various fields of biophysics, biochemistry, molecular biology, genetics, cell biology and physiology. Also of interest, this volume contains an historical introduction, including a list of earlier publications relating to the history of bioenergetics.
| Author | : Valdur Saks |
| Publisher | : John Wiley & Sons |
| Total Pages | : 633 |
| Release | : 2008-01-08 |
| Genre | : Science |
| ISBN | : 3527621105 |
Download Molecular System Bioenergetics Book in PDF, ePub and Kindle
In this first integrated view, practically each of the world's leading experts has contributed to this one and only authoritative resource on the topic. Bringing systems biology to cellular energetics, they address in detail such novel concepts as metabolite channeling and medical aspects of metabolic syndrome and cancer.
| Author | : Joachim Frank |
| Publisher | : Cambridge University Press |
| Total Pages | : 287 |
| Release | : 2011-12-19 |
| Genre | : Science |
| ISBN | : 1139499904 |
Download Molecular Machines in Biology Book in PDF, ePub and Kindle
The concept of molecular machines in biology has transformed the medical field in a profound way. Many essential processes that occur in the cell, including transcription, translation, protein folding and protein degradation, are all carried out by molecular machines. This volume focuses on important molecular machines whose architecture is known and whose functional principles have been established by tools of biophysical imaging (X-ray crystallography and cryo-electron microscopy) and fluorescence probing (single-molecule FRET). This edited volume includes contributions from prominent scientists and researchers who understand and have explored the structure and functions of these machines. This book is essential for students and professionals in the medical field who want to learn more about molecular machines.
| Author | : Jean-Daniel Horisberger |
| Publisher | : R. G. Landes |
| Total Pages | : 148 |
| Release | : 1994 |
| Genre | : Medical |
| ISBN | : |
Download The Na, K-ATPase Book in PDF, ePub and Kindle
This text addresses the question, How does the sodium pump pump'. A variety of primary structure information is available, and progress has been made in the functional characterization of the Na, K-pump, making the answer to this question possible, within reach of currently used techniques
| Author | : Morris Karmazyn |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 538 |
| Release | : 1996-08-28 |
| Genre | : Medical |
| ISBN | : 9783764352691 |
Download Myocardial Ischemia: Mechanisms, Reperfusion, Protection Book in PDF, ePub and Kindle
Myocardial ischemia and subsequent reperfusion of the ischemic myocardium represent complex phenomena encompassing numerous physiological processes. This book aims at enhancing our understanding of these processes and stresses recent important developments in this very active area of research. The concise, state-of-the-art reviews cover recent advances in many fields important to the area of myocardial ischemia and reperfusion including physiology, pathology, pharmacology, biochemistry and molecular biology with reference to clinical relevance and applicability of these findings. Major areas which are highlighted include vascular mechanisms resulting in myocardial ischemia, cellular events in the ischemic, postinfarcted and reperfused myocardium as well as new exciting developments in cardiac protection that involve both novel pharmacological approaches as well as endogenous cardioprotective mechanisms such as preconditioning. Aimed at both the basic and clinical cardiovascular investigator, the book comprehensively reviews the rapid progress made in recent years in understanding the etiology of myocardial ischemia and reperfusion. It will further serve as an authoritative reference for all those interested in learning about the important developments in the treatment of myocardial ischemic and reperfusion disorders.
