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MDMA-Assisted Therapy for Treatment of PTSD and Beyond

MDMA-Assisted Therapy for Treatment of PTSD and Beyond
Author: Rick Doblin
Publisher: Frontiers Media SA
Total Pages: 120
Release: 2023-07-31
Genre: Medical
ISBN: 2832530230

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In 2017, the Food and Drug Administration (FDA) granted breakthrough therapy designation for 3,4-methylenedioxymethamphetamine assisted therapy (MDMA-AT) for the treatment of posttraumatic stress disorder (PTSD). Six phase 2 and one phase 3 trial of a standardized MDMA-AT protocol for PTSD have consistently shown that the treatment is both safe and efficacious. MDMA-AT may hold great promise as a novel treatment for individuals who suffer from PTSD, including those with severe and treatment-resistant diagnoses. Evidence-based studies are needed to guide widespread adoption and dissemination of MDMA-AT for PTSD. The untapped therapeutic potential of MDMA-AT also warrants further investigation of indications beyond PTSD, including comorbidities that often create greater challenges in treatment and long-term efficacy. The goal of this Research Topic is to broaden the scientific literature on MDMA-AT across disciplines. Specifically, studies are needed to provide (i) guidance on the dissemination of MDMA-AT for PTSD, (ii) future research directions for MDMA-AT including investigation of other indications, and (iii) theoretical frameworks and models of biological mechanisms to explain the therapeutic effects of MDMA-AT.


Beyond Ecstasy

Beyond Ecstasy
Author: Ben Sessa
Publisher:
Total Pages: 0
Release: 2024-08-07
Genre: Health & Fitness
ISBN: 9781022903340

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Breaking Through the Stigma: MDMA-Assisted Psychotherapy and the Path to Healing The story of MDMA is one of remarkable transformation. Often known for its recreational use under the moniker 'ecstasy, ' this drug has garnered both cultural fascination and stigmatization. However, buried beneath the layers of controversy, lies an untapped therapeutic potential rapidly gaining scientific credence: the employment of MDMA in clinical settings, particularly for treating post-traumatic stress disorder (PTSD) and other mental health conditions. 'Beyond Ecstasy: The Hidden Therapeutic Potential of MDMA' is a thoughtfully curated collection of scientific journal articles that investigates this transformative journey from a synthesized molecule to a potential healing agent. The book reviews the neurobiological mechanisms that set MDMA apart, showcasing its ability to foster empathy and emotional connection, critical elements that enable profound therapeutic experiences. It examines the human stories of relief and reconnection emerging from clinical trials. From enhancing relational therapies by improving communication and intimacy, to demonstrating significant cost-effectiveness and long-term benefits, this compilation covers the multifaceted implications of MDMA-assisted psychotherapy. Key articles spotlight randomized, double-blind, placebo-controlled trials, elucidating the promising clinical outcomes against PTSD and the safety concerns evaluated through extensive studies. The book takes an in-depth look at the broader societal impacts, including healthcare savings and quality of life improvements, urging a re-evaluation of how psychoactive substances are perceived and utilized within mental health treatment paradigms. As you journey through these compelling studies, 'Beyond Ecstasy' not only aims to educate but also to inspire hope. It presents a bold narrative that challenges conventional perceptions and opens doors to new beginnings for those underserved by current treatments, highlighting a path forward to dismantling long-held stigmas. Quality Research Publishing is dedicated to making knowledge more accessible to the general public by curating a topical compilation of the latest research on various subjects and providing plain language summaries. Each of the articles in this book is available individually and digitally without cost. However, we believe it is important for the contextualizing and sharing of educational and scientific work to curate this research in a way that is understandable and helpful to the average person seeking deeper knowledge of a particular subject. The research articles compiled for this book were published under a permissive Creative Commons license, are in the public domain, or have no copyright restrictions, permitting their use in this book. If you have questions about the licensing of any article, please visit qualityresearchpublishing.com.


Facilitating Posttraumatic Growth

Facilitating Posttraumatic Growth
Author: Lawrence G. Calhoun
Publisher: Routledge
Total Pages: 178
Release: 1999-07
Genre: Psychology
ISBN: 1135688613

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In this book, Calhoun and Tedeschi construct the first systematic framework for clinical efforts to enhance the processes they sum up as posttraumatic growth. Posttraumatic growth is the phenomenon of positive change through struggle with even the most horrible sets of circumstances. People who experience it tend to describe three general types of change: realistically stronger feelings of vulnerability that are nonetheless accompanied by stronger feelings of personal resilience, closer and deeper relationships with others, and a stronger sense of spirituality. Posttraumatic growth has only recently become an important focus of interest for researchers and practitioners. Drawing on a burgeoning professional literature as well as on their own extensive clinical experience, the authors present strategies for helping clients effect all three types of positive change--strategies that have been tested in a variety of groups facing a variety of crises and traumas. Their concise yet comprehensive practical guide will be welcomed by all those who counsel persons grappling with the worst life has to offer.


MDMA-Assisted Psychotherapy for Posttraumatic Stress Disorder

MDMA-Assisted Psychotherapy for Posttraumatic Stress Disorder
Author: Terence Ching
Publisher:
Total Pages: 0
Release: 2020
Genre:
ISBN:

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MDMA-assisted psychotherapy was shown in previous clinical trials to be efficacious and safe for alleviating treatment-resistant posttraumatic stress disorder (PTSD). However, due to low ethnoracial diversity, the question remains as to whether ethnoracial minority participants would benefit similarly. Thus, in Study 1, ethnoracial differences in PTSD symptoms, secondary outcomes, and suicidality were examined for a multisite, open-label trial of MDMA-assisted psychotherapy. A total of 11 ethnoracial minority and 26 non-Hispanic White participants formed the modified intent-to-treat (ITT) set. General and generalized linear model analyses were used to test group differences. Correlational analyses were conducted to test relationships between changes in certain secondary outcomes/putative mechanisms of action and PTSD symptoms for the entire sample. Results indicated overall ethnoracial equivalence in efficacy and safety/suicidality, with majority large effect sizes in symptom improvement across groups. Ethnoracial minority participants seemed to self-report lower PTSD symptom reduction after the first dose, although this difference was erased after the second and third doses. Additionally, improved alexithymic tendencies, emotion regulation ability, and self-compassion were significantly correlated with reduced PTSD symptoms. These findings provided preliminary support for the efficacy and safety of MDMA-assisted psychotherapy for treating PTSD across ethnoracial groups, although more research needs to be conducted with larger, more diverse samples. In Study 2, a mixed-methods case study was conducted on an ethnoracial minority participant from the same open-label trial, to provide a culturally informed lens on recovery from PTSD in a participant of color with MDMA-assisted psychotherapy. A case profile was provided, documenting quantitative symptom improvement on all measures from Study 1. This was followed by an interpretative phenomenological analysis (IPA) of effects and mechanisms of action for this participant, based on integration session transcripts. Lastly, linguistic variables inherent within the participant's transcripts were entered into exploratory correlational analysis with his PTSD symptom scores. Results of IPA indicated recurrent themes related to: mechanisms of change; reduced PTSD symptoms; additional effects beyond PTSD symptom reduction; and navigating interpersonal relationships. Correlational findings indicated meaningful relationships between several linguistic variables (e.g., increased authenticity) and PTSD symptom reduction. Lastly, recommendations for diversifying ongoing MDMA-assisted psychotherapy trials were provided.


A Dose of Hope

A Dose of Hope
Author: Dan Engle
Publisher:
Total Pages: 334
Release: 2021-07-02
Genre:
ISBN: 9781544521039

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MDMA-assisted therapy for PTSD is in the final stages of FDA testing. Clinical trials are reporting a 70 percent cure rate for a condition that claims thousands of lives globally every day-hundreds in the US alone. But until it's fully legalized, MDMA is still a Schedule I drug, saddled with years of misunderstanding, misinformation, and misuse. In this groundbreaking, informative, and easy-to-read book, Dr. Dan Engle shows you the treatment through the eyes of a fictional patient so you can see how it works without ever setting foot in a doctor's office. Follow in-depth conversations between doctor and patient, learn about the history of MDMA-assisted therapy, understand how and why it helps, and experience the process for yourself-without ever having to take anything.  The treatment presented here is a synthesis of the real experiences and stunning results happening today in trials around the world. Whether you or a loved one suffer from PTSD, or you just want to heal something that's keeping you from living your best life, don't miss A Dose of Hope.


A Dose of Hope

A Dose of Hope
Author: Dan Engle
Publisher: Lioncrest Publishing
Total Pages: 334
Release: 2021-07-20
Genre:
ISBN: 9781544521022

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MDMA-assisted therapy for PTSD is in the final stages of FDA testing. Clinical trials are reporting a 70 percent cure rate for a condition that claims thousands of lives globally every day-hundreds in the US alone. But until it's fully legalized, MDMA is still a Schedule I drug, saddled with years of misunderstanding, misinformation, and misuse. In this groundbreaking, informative, and easy-to-read book, Dr. Dan Engle shows you the treatment through the eyes of a fictional patient so you can see how it works without ever setting foot in a doctor's office. Follow in-depth conversations between doctor and patient, learn about the history of MDMA-assisted therapy, understand how and why it helps, and experience the process for yourself-without ever having to take anything.  The treatment presented here is a synthesis of the real experiences and stunning results happening today in trials around the world. Whether you or a loved one suffer from PTSD, or you just want to heal something that's keeping you from living your best life, don't miss A Dose of Hope.


Psychedelic Medicine [2 Volumes]

Psychedelic Medicine [2 Volumes]
Author: Michael J. Winkelman
Publisher: Praeger
Total Pages: 0
Release: 2007-06-30
Genre: Psychology
ISBN: 0275990230

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A collection of essays examining the current status of the therapeutic potential of hallucinogenic substances, exploring how the drugs can be used to effectively treat a wide range of conditions.


Healing with Entactogens

Healing with Entactogens
Author: Torsten Passie
Publisher: Multidisciplinary Association for Psychedelic Studies
Total Pages: 90
Release: 2012
Genre: Body, Mind & Spirit
ISBN: 9780979862274

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This booklet explores MDMA and other entactogens as pharmacological adjuncts to group psychotherapy. It presents intimate insights into entactogenic experiences from first-hand accounts of clients who participated in group therapy sessions, and crucial background on the neurobiological and psychospiritual components of those experiences. The word "entactogen" refers to compounds that "produce a touching within," and is derived from the roots en (Greek: within), tact's (Latin: touch), and gen (Greek: produce. Entactogen is used to describe a class of psychoactive substances that decrease anxiety; increase trust, self-acceptance, and openness; and allow easier access to memories, providing fertile ground for transformative healing. Therapists used entactogens such as MDMA in their practice before it was criminalized in 1985. Since that time, much effort has taken place to conduct government-approved scientific research into MDMA's therapeutic potential, which has recently been demonstrated in placebo-controlled studies of MDMA-assisted psychotherapy for subjects with chronic, treatment-resistant posttraumatic stress disorder.


Psychedelics and Psychotherapy

Psychedelics and Psychotherapy
Author: Tim Read
Publisher: Simon and Schuster
Total Pages: 535
Release: 2021-09-07
Genre: Body, Mind & Spirit
ISBN: 1644113333

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• Examines the therapeutic potential of expanded states, underground psychedelic psychotherapy, harm reduction, new approaches for healing individual and collective trauma, and training considerations • Addresses challenging psychedelic experiences, spiritual emergencies, and the central importance of the therapeutic relationship • Details the use of cannabis as a psychedelic tool, spiritual exploration with LSD, micro-dosing with Iboga, and MDMA-assisted psychotherapy for PTSD Exploring the latest developments in the flourishing field of modern psychedelic psycho-therapy, this book shares practical experiences and insights from both elders and newer research voices in the psychedelic research and clinical communities. The contributors examine new findings on safe and skillful work with psychedelic and expanded states for therapeutic, personal, and spiritual growth. They explain the dual process of opening and healing. They explore new approaches for individual inner work as well as for the healing of ancestral and collective trauma. They examine the power of expanded states for reparative attachment work and offer insights on the integration process through the lens of Holotropic Breathwork. The contributors also examine the use of cannabis as a psychedelic tool, spiritual exploration with LSD, microdosing with Iboga, treating depression with psilocybin, and MDMA-assisted psychotherapy for PTSD. Revealing diverse ways of working with psychedelics in terms of set, setting, and type of substance, the book concludes with discussions of ethics and professional development for those working in the field as well as explores considerations for training the next generation of psychedelic therapists.


Human Caring Science

Human Caring Science
Author: Jean Watson
Publisher: Jones & Bartlett Publishers
Total Pages: 136
Release: 2012
Genre: Medical
ISBN: 1449628109

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Rev. ed. of: Nursing: human science and human care / Jean Watson. c1999.