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Treatment of Tuberculosis

Treatment of Tuberculosis
Author: World Health Organization
Publisher:
Total Pages: 60
Release: 1993
Genre: Antitubercular agents
ISBN:

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Guidelines for the Programmatic Management of Drug-Resistant Tuberculosis

Guidelines for the Programmatic Management of Drug-Resistant Tuberculosis
Author: World Health Organization
Publisher:
Total Pages: 0
Release: 2015-04-20
Genre: Medical
ISBN: 9789241501583

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This 2011 update of Guidelines for the programmatic management of drug-resistant tuberculosis is intended as a tool for use by public health professionals working in response to the Sixty-second World Health Assembly's resolution on prevention and control of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis. Resolution WHA62.15, adopted in 2009, calls on Member States to develop a comprehensive framework for the management and care of patients with drug-resistant TB. The recommendations contained in these guidelines address the most topical questions concerning the programmatic management of drug-resistant TB: case-finding, multidrug resistance, treatment regimens, monitoring the response to treatment, and selecting models of care. The guidelines primarily target staff and medical practitioners working in TB treatment and control, and partners and organizations providing technical and financial support for care of drug-resistant TB in settings where resources are limited.


WHO consolidated guidelines on tuberculosis. Module 4

WHO consolidated guidelines on tuberculosis. Module 4
Author: World Health Organization
Publisher: World Health Organization
Total Pages: 72
Release: 2022-04-30
Genre: Medical
ISBN: 924004812X

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Between 2011 and 2019, WHO has developed and issued evidence-based policy recommendations on the treatment and care of patients with DR-TB. These policy recommendations have been presented in several WHO documents and their associated annexes, including the WHO Consolidated Guidelines on Drug Resistant Tuberculosis Treatment, issued by WHO in March 2019. The policy recommendations in each of these guidelines have been developed by WHO-convened Guideline Development Groups, using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach to summarize the evidence, and formulate policy recommendations and accompanying remarks. The present WHO Consolidated Guidelines on Tuberculosis, Module 4: Treatment - Drug-Resistant Tuberculosis Treatment includes a comprehensive set of WHO recommendations for the treatment and care of DR-TB. The document includes two new recommendations, one on the composition of shorter regimens and one on the use of the BPaL regimen (i.e. bedaquiline, pretomanid and linezolid). In addition, the consolidated guidelines include existing recommendations on treatment regimens for isoniazid-resistant TB and MDR/RR-TB, including longer regimens, culture monitoring of patients on treatment, the timing of antiretroviral therapy (ART) in MDR/RR-TB patients infected with the human immunodeficiency virus (HIV), the use of surgery for patients receiving MDR-TB treatment, and optimal models of patient support and care. The guidelines are to be used primarily in national TB programmes, or their equivalents in Ministries of Health, and for other policy-makers and technical organizations working on TB and infectious diseases in public and private sectors and in the community.


Guidelines for the Programmatic Management of Drug-resistant Tuberculosis

Guidelines for the Programmatic Management of Drug-resistant Tuberculosis
Author: World Health Organization
Publisher: World Health Organization
Total Pages: 271
Release: 2008
Genre: Business & Economics
ISBN: 9241547588

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The emergence of extensively drug-resistant strains of tuberculosis, especially in countries with a high prevalence of human immunodeficiency virus, is a serious threat to global public health and jeopardizes efforts to effectively control the disease. This publication offers updated recommendations for the diagnosis and management of drug-resistant tuberculosis in a variety of geographical, economic and social settings, and the recording of data that enables the monitoring and evaluation of programs.--Publisher's description.


Guidance for National Tuberculosis Programmes on the Management of Tuberculosis in Children

Guidance for National Tuberculosis Programmes on the Management of Tuberculosis in Children
Author: World Health Organization
Publisher:
Total Pages: 0
Release: 2015-02-05
Genre: Medical
ISBN: 9789241548748

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It is estimated that one third of the world's population is infected with Mycobacterium tuberculosis (the bacterium that causes tuberculosis (TB)), and that each year, about 9 million people develop TB, of whom about 2 million die. Of the 9 million annual TB cases, about 1 million (11%) occur in children (under 15 years of age). Of these childhood cases, 75% occur annually in 22 high-burden countries that together account for 80% of the world's estimated incident cases. In countries worldwide, the reported percentage of all TB cases occurring in children varies from 3% to more than 25%. The Stop TB Strategy, which builds on the DOTS strategy developed by the World Health Organization (WHO) and the International Union Against TB and Lung Disease, has a critical role in reducing the worldwide burden of disease and thus in protecting children from infection and disease. The management of children with TB should be in line with the Stop TB Strategy, taking into consideration the particular epidemiology and clinical presentation of TB in children. These consensus guidelines were produced to help the National Tuberculosis Programmes on the management of tuberculosis in children.


Management of MDR-TB

Management of MDR-TB
Author: World Health Organization
Publisher: World Health Organization
Total Pages: 61
Release: 2009
Genre: Medical
ISBN: 9241547766

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Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) are increasingly encountered in resource-limited settings. In the context of a national response to MDR- and XDR-TB, health workers in TB clinics (in district hospitals and some accredited health centers) will need to diagnose MDR-TB, initiate second-line anti-TB drugs, and monitor MDR-TB treatment. This Field Guide was created to help health workers carry out these tasks. It is a job aid that medical officers and TB nurses are meant to use frequently during the day for quick reference. It is based on the Emergency Update 2008 of Guidelines for Programmatic Management of Drug-resistant Tuberculosis, and may be considered a companion document to these guidelines. It also draws on the experience of the international health NGO Partners In Health (PIH) in many countries. This module should be introduced to health workers in the context of a training course with a strong emphasis on TB-HIV co-management.


The Use of Bedaquiline in the Treatment of Multidrug-resistant Tuberculosis

The Use of Bedaquiline in the Treatment of Multidrug-resistant Tuberculosis
Author: World Health Organization
Publisher:
Total Pages: 0
Release: 2015-04-20
Genre: Medical
ISBN: 9789241505482

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WHO estimates that up to half a million new cases of multidrug-resistant tuberculosis (MDR-TB) occur worldwide, each year. Current treatment regimens for MDR-TB present many challenges: treatment lasts 20 months or more, requiring daily administration of drugs that are more toxic, less effective, and far more expensive than those used to treat drug-susceptible TB. Globally, less than half of all patients who start MDR-TB therapy are treated successfully. For the first time in over 40 years, a new TB drug with a novel mechanism of action - bedaquiline- is available, and was granted accelerated approval by the United States Food and Drug Administration in December 2012. There is considerable interest in the potential of this drug to treat MDR-TB. However, information about this new drug remains limited. It has only been through two Phase IIb trials for safety and efficacy. The World Health Organization (WHO) is therefore issuing "interim policy guidance". This interim guidance provides advice on the inclusion of bedaquiline in the combination therapy of MDR-TB in accordance with the existing WHO Guidelines for the Programmatic Management of Drug-resistant TB (2011 Update).


Nanotechnology Based Approaches for Tuberculosis Treatment

Nanotechnology Based Approaches for Tuberculosis Treatment
Author: Prashant Kesharwani
Publisher: Academic Press
Total Pages: 284
Release: 2020-06-10
Genre: Business & Economics
ISBN: 0128226110

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Nanotechnology Based Approaches for Tuberculosis Treatment discusses multiple nanotechnology-based approaches that may help overcome persisting limitations of conventional and traditional treatments. The book summarizes the types of nano drugs, their synthesis, formulation, characterization and applications, along with the most important administration routes. It also explores recent advances and achievements regarding therapeutic efficacy and provides possible future applications in this field. It will be a useful resource for investigators, pharmaceutical researchers, innovators and scientists working on technology advancements in the areas of targeted therapies, nano scale imaging systems, and diagnostic modalities in tuberculosis. Addresses the gap between nanomedicine late discovery and early development of tuberculosis therapeutics Explores tuberculosis nanomedicine standardization and characterization with newly developed treatment, diagnostic and treatment monitoring modalities Covers the field thoroughly, from the pathogenesis of tuberculosis and multi-drug resistant mycobacterium tuberculosis, to treatment approaches using nanotechnology and different nanocarriers


Guidance on Ethics of Tuberculosis Prevention, Care and Control

Guidance on Ethics of Tuberculosis Prevention, Care and Control
Author: World Health Organization
Publisher:
Total Pages: 0
Release: 2015-04-20
Genre: Medical
ISBN: 9789241500531

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With the growing breadth and complexity of TB efforts today comes a greater range of concerns associated with the ethics of action, inaction and specific approaches to clinical, public health and research interventions. In 2006, the documented emergence of extensively drug-resistant tuberculosis (XDR-TB),2 including a dramatic and lethal outbreak in South Africa, brought forward urgent issues of public health ethics given the imposition in some programs of involuntary detention of persons suspected and/or confirmed of being ill with drug-resistant TB under the justification of public safety. In a linked effort, the Stop TB Partnership agreed to establish a TB and Human Rights Task Force in 2010, with secretariat being provided by WHO and the Joint United Nations Program on HIV/AIDS (UNAIDS). The Task Force will aim to develop a policy framework for a rights-based approach to TB prevention, care and control as joint products of WHO, the Stop TB Partnership and UNAIDS. It will also propose a strategic agenda for action. It will be composed of major stakeholders, constituencies from affected communities and risk groups, human rights and civil society organizations, health and human rights experts, United Nations agencies, and development partners. This ethics guidance and the resulting rights-based policy framework will be used as complementary and companion documents to guide further dialogue and action in these areas.