Lymphocytes Macrophages And Cancer PDF Download
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Author | : G. Mathe |
Publisher | : Springer Science & Business Media |
Total Pages | : 266 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3642810497 |
Download Lymphocytes, Macrophages, and Cancer Book in PDF, ePub and Kindle
Fresh living Bacillus Calmette-Guerin (BeG), injected i.v. into (C57BI/ 6xDBA/2)FI mice, activated peritoneal macrophages rendering them highly cytotoxic for tumor cells in vitro. This cytotoxic activity w~s already maximal 14 days after injection of 1 mg of BCG and remained stable when 3 or 5 mg of BCG were given. At the same time spleen cells of the BCG-treat~d mice showed strongly depressed responses to the T-cell mitogens,PHA and Con A, irrespective of the dose of BCG injected. The inhibitory effect was shown to be mediated by suppressor cells which had characteristics of macrophages since they could be removed by carbonyl iron and magnet treatment and were adherent to plastic. In contrast to it was observed after injec tion of 1 mg of BCG, these suppressor cells alone did not account for the depression of T-cell re.sponses induced by higher doses of BCG. Nylon-nonadherent cell populations obtained from spleen cells treated with 3 or 5 mg BCG partially retained the inhibitory activity suggesting that suppressor T cells were also induced after injection of high doses of BCG. In contrast, the responses to the B-cell mitogen LPS of unfractionated and macrophage-depleted spleen cells were not affected or significantly enhanced depending on the dose of BCG injected.
Author | : M. R. Escobar |
Publisher | : Springer Science & Business Media |
Total Pages | : 639 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 1468435930 |
Download Macrophages and Lymphocytes Book in PDF, ePub and Kindle
The Reticuloendothelial (RE) Society, which is concerned with advd~cement of knowledge concerning the many diverse functions of RE cells, organizes national and international meetings and publishes a scientific journal. The VIII International Congress of the RE Society was held in Jerusalem, Israel, June 18-23, 1978. The Congress had as its scientific objec,tive a wide range of sub jects concerning the RE System, especially as related to macro phage function and interaction with lymphocytes. Emphasis of the Congress was placed on the nature and function of macrophages and other cells of the RE System with reference to immune responses, anti-infectious activity, tumor immunity, autoimmunity, and trans plant rejection. The secretion of soluble factors by rnacrophages and lymphocytes and the mode of action of these factors on other cells was stressed. During the Congress some discussion was entertained concerning the controversy as to what constitutes the "RE System" per se. Some investigators feel that the phagocytic activity of rnacrophages is the most important aspect of the RE System playing also a major role in many parameters of immunity. Mononuclear phagocytes include tissue rnacrophages as well as cir culating monocytes and their precursors. Although phagocytosis is a major functional activity of these cells, it is only one of several activities.
Author | : Alberto Mantovani |
Publisher | : Elsevier Inc. Chapters |
Total Pages | : 43 |
Release | : 2013-06-04 |
Genre | : Medical |
ISBN | : 0128059230 |
Download Cancer Immunotherapy Book in PDF, ePub and Kindle
Tumor development and progression are strongly linked to inflammation and macrophage infiltration is a major component of the inflammatory reactions associated with neoplasia. Plasticity is a hallmark of mononuclear phagocytes, which undergo polarized diverse forms of activation. Metabolic adaptation is a key component of macrophage plasticity and polarization, instrumental to their function in homeostasis, immunity and inflammation. Tumor-associated macrophages (TAM) and related immature myeloid suppressor cells generally have properties of an M2-like population. TAM produce growth factors, have immunoregulatory and immunosuppressive activity, stimulate angiogenesis and provide tissue remodeling, invasion and metastasis. Thus, TAM are a key component of cancer-promoting inflammatory reactions.
Author | : Mary Fink |
Publisher | : Elsevier |
Total Pages | : 276 |
Release | : 2012-12-02 |
Genre | : Medical |
ISBN | : 0323158153 |
Download The Macrophage In Neoplasia Book in PDF, ePub and Kindle
The Macrophage in Neoplasia is a compilation of papers presented at a workshop held at the Marine Biological Laboratory, Woods Hole, Massachusetts, on October 8-11, 1975. The book presents the many faceted activities of macrophage. This book is divided according to the five sessions of the workshop. First session talks about the role of tumor macrophages in vivo. It then elucidates the macrophage function and indicates how the interaction of macrophages with other cells can alter the host-tumor balance. The remaining sessions, as presented in this book, explore the mechanism of macrophage mediated cytotoxicity, functional expression of macrophages and neoplasia, and the stimulation of macrophage function and applied therapy.
Author | : Gloria H. Heppner |
Publisher | : CRC Press |
Total Pages | : 229 |
Release | : 2019-06-04 |
Genre | : Medical |
ISBN | : 1000006158 |
Download Macrophages & Cancer Book in PDF, ePub and Kindle
First Published in 1988, this book offers a full, comprehensive guide into the relationship between macrophages and Cancer. Carefully compiled and filled with a vast repertoire of notes and references this book serves as a useful reference for Students of Medicine, Oncology and other practitioners in their respective fields.
Author | : Reticuloendothelial Society. International Congress |
Publisher | : Springer |
Total Pages | : 640 |
Release | : 1980 |
Genre | : Medical |
ISBN | : |
Download Macrophages and Lymphocytes Book in PDF, ePub and Kindle
The Reticuloendothelial (RE) Society, which is concerned with advancement of knowledge concerning the many diverse functions of RE cells, organizes national and international meetings and publishes a scientific journal. The VIII International Congress of theRE Society was held in Jerusalem, Israel, June 18-23, 1978. The Congress had as its scientific objective a wide range of sub jects concerning the RE System, especially as related to macro phage function and interaction with lymphocytes. Emphasis of the Congress was placed on the nature and function of macrophages and other cells of the RE System with reference to immune responses, anti-infectious activity, tumor immunity, autoimmunity, and trans plant rejection. The secretion of soluble factors by macrophages and lymphocytes and the mode of action of these factors on other cells was stressed. During the Congress some discussion was entertained concerning the controversy as to what constitutes the "RE System" per se. Some investigators feel that the phagocytic activity of ~~crophages is the most important aspect of the RE System playing also a major role in many parameters of immunity. Mononuclear phagocytes include tissue macrophages as well as cir culating monocytes and their precursors. Although phagocytosis is a major functional activity of these cells, it is only one of several activities.
Author | : Maurie Markman |
Publisher | : Springer Science & Business Media |
Total Pages | : 363 |
Release | : 2000-01-02 |
Genre | : Medical |
ISBN | : 1592592198 |
Download Regional Chemotherapy Book in PDF, ePub and Kindle
Maurie Markman and a panel of distinguished clinicians and leading clinical investigators comprehensively review the current status of regional antineoplastic drug delivery in the management of malignant disease. These authorities present a critical analysis of both the rationale and limitations of regional therapy and discuss potential clinical trials designed to explain the effectiveness of this method of therapy in special settings. Their presentations describe many exciting and innovative strategies for using regional drug delivery in anticancer therapy, including coverage of such areas of special interest as colorectal, skin, lung, pancreatic, ovarian, and gastrointestinal cancers. Comprehensive and authoritative, Regional Chemotherapy: Clinical Research and Practice offers surgical and medical oncologists and clinical cancer investigators a gold-standard review of the current role and future development of this increasingly powerful weapon in the battle against cancer.
Author | : Toby Lawrence |
Publisher | : Springer Science & Business Media |
Total Pages | : 189 |
Release | : 2011-10-06 |
Genre | : Medical |
ISBN | : 1461406625 |
Download Tumour-Associated Macrophages Book in PDF, ePub and Kindle
The subject of Tumour-Associated Macrophages is of interest in the cancer research community, and this book promises to be among the first to discuss a definitive theory on the role of macrophage in tumor development.
Author | : David S. Nelson |
Publisher | : Academic Press |
Total Pages | : 652 |
Release | : 2014-06-28 |
Genre | : Nature |
ISBN | : 1483274772 |
Download Immunobiology of the Macrophage Book in PDF, ePub and Kindle
Immunobiology of the Macrophage presents an account of the state of knowledge of the immunobiology of the macrophage. The book’s contributors—immunologists of diverse scientific and geographic backgrounds—have been encouraged to give personal accounts of developments in their special fields of interest as well as critical surveys of the backgrounds leading to these developments. The book begins with a study on the functions of macrophages in the initiation and regulation of antibody responses in vitro. This is followed by separate chapters on topics such as the role of macrophages in making antigen more immunogenic and less tolerogenic; functional distinctions between macrophages at different sites; and the role of the macrophage in antigen recognition by T lymphocytes. Subsequent chapters examine interactions between macrophages and lymphocytes in the production of interferon and other mediators of cellular immunity; macrophage cell lines and their uses in immunobiology; and cytotoxic macrophages in allograft rejection.
Author | : Alecsandru Ioan Baba |
Publisher | : |
Total Pages | : 787 |
Release | : 2007 |
Genre | : Electronic books |
ISBN | : 9789732714577 |
Download Comparative Oncology Book in PDF, ePub and Kindle