Lymph Node T Cell Dynamics And Novel Strategies For Hiv Cure PDF Download
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Author | : Constantinos Petrovas |
Publisher | : Frontiers Media SA |
Total Pages | : 186 |
Release | : 2019-02-11 |
Genre | : |
ISBN | : 2889457583 |
Download Lymph Node T Cell Dynamics and Novel Strategies for HIV Cure Book in PDF, ePub and Kindle
Currently, more than 36 million people are infected with HIV. Although the introduction of highly active anti-retroviral therapy (HAART) has led to substantial advances in the clinical management of HIV infected individuals, HAART cannot completely eliminate the virus. This is because CD4 T helper cells, harboring the virus, remain dormant reservoirs. These reservoirs are difficult to measure and are present even in HAART-treated HIV infected individuals with undetectable levels of HIV in the blood. A growing body of studies has revealed follicular helper (Tfh) CD4 T cells, a highly differentiated CD4 T cell population localized in immunologically sanctuary sites (follicle/germinal center), as a major reservoir of HIV. The present Frontiers in Immunology eBook compiles 16 timely review articles focusing on the dynamics of major follicular immune cell types in HIV/SIV infection and their potential role for disease pathogenesis and the viral persistence in the lymph node. This eBook provides a comprehensive presentation of recent published work on lymph node and especially Tfh cell dynamics in HIV infection and we hope that it will be useful for our further understanding of how such dynamics affect the interplay between virus and host as well as for the discovery of novel therapeutic targets in the fight against HIV.
Author | : Guido Silvestri |
Publisher | : Springer |
Total Pages | : 248 |
Release | : 2018-10-11 |
Genre | : Medical |
ISBN | : 303002816X |
Download HIV-1 Latency Book in PDF, ePub and Kindle
This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.
Author | : Sunil Kannanganat Sidharthan |
Publisher | : Frontiers Media SA |
Total Pages | : 230 |
Release | : 2023-07-26 |
Genre | : Medical |
ISBN | : 2832530761 |
Download CD4 T cells in HIV: A friend or foe? Book in PDF, ePub and Kindle
Author | : King K. Holmes |
Publisher | : World Bank Publications |
Total Pages | : 1027 |
Release | : 2017-11-06 |
Genre | : Medical |
ISBN | : 1464805253 |
Download Disease Control Priorities, Third Edition (Volume 6) Book in PDF, ePub and Kindle
Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Author | : Anthony S. Fauci |
Publisher | : Springer Science & Business Media |
Total Pages | : 159 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3642608671 |
Download Immunopathogenesis of HIV Infection Book in PDF, ePub and Kindle
During the last 5 years, major advances have been made in our understanding of the pathogenesis of human immunodeficiency virus (HIV) disease and in the development of new potent antiviral agents. With regard to HIV pathogenesis, several recent observations have not only changed our perspectives of HIV disease, but have been critical for the design of therapeutic strategies.
Author | : Gianfranco Pancino |
Publisher | : Academic Press |
Total Pages | : 362 |
Release | : 2011-12-02 |
Genre | : Medical |
ISBN | : 0123877156 |
Download Models of Protection Against HIV/SIV Book in PDF, ePub and Kindle
A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency. Models of Protection Against HIV/SIV will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barré-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer. This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike. Provides extensive descriptions and comparisons on the different models of protection agains HIV/AIDS Comprehensive writing and illustrations Contributors are among the most eminent specialists in the field
Author | : Margaret Ackerman |
Publisher | : Academic Press |
Total Pages | : 376 |
Release | : 2013-08-06 |
Genre | : Medical |
ISBN | : 0123948185 |
Download Antibody Fc Book in PDF, ePub and Kindle
Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells. Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitro Covers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodies Color illustrations enhance explanations of the immune system
Author | : Hiroshi Kiyono |
Publisher | : Elsevier |
Total Pages | : 501 |
Release | : 1996-10-23 |
Genre | : Medical |
ISBN | : 0080537057 |
Download Mucosal Vaccines Book in PDF, ePub and Kindle
This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. Provides the latest views on mucosal vaccines Applies basic principles to the development of new vaccines Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases Unique and user-friendly organization
Author | : Tamas Fulop |
Publisher | : Springer Science & Business Media |
Total Pages | : 1693 |
Release | : 2009-02-27 |
Genre | : Medical |
ISBN | : 1402090633 |
Download Handbook on Immunosenescence Book in PDF, ePub and Kindle
This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.
Author | : Renee Marije Van Der Sluis |
Publisher | : Frontiers Media SA |
Total Pages | : 111 |
Release | : 2021-04-07 |
Genre | : Science |
ISBN | : 2889666662 |
Download Exploring Novel Approaches to Eliminate HIV Reservoirs to Achieve a Cure for HIV Book in PDF, ePub and Kindle