Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Low Density Lipoprotein Induced Cytotoxicity And Its Inhibition By High Density Lipoprotein In Human Vascular Smooth Muscle And Endothelial Cells In Culture PDF full book. Access full book title Low Density Lipoprotein Induced Cytotoxicity And Its Inhibition By High Density Lipoprotein In Human Vascular Smooth Muscle And Endothelial Cells In Culture.
| Author | : James Robert Hessler |
| Publisher | : |
| Total Pages | : 462 |
| Release | : 1979 |
| Genre | : |
| ISBN | : |
| Author | : Anatol Kontush |
| Publisher | : John Wiley & Sons |
| Total Pages | : 786 |
| Release | : 2011-11-30 |
| Genre | : Science |
| ISBN | : 1118158660 |
A complete guide to the role of high-density lipoproteins (HDL) in new and emerging therapies With high-density lipoproteins (HDL) playing an increasing role in cardiovascular disease prevention, there is a growing need for an in-depth look at HDL and its clinical value. This book summarizes the current state of knowledge in the field, providing for the first time a comprehensive, systematic, stylistically coherent, and up-to-date review of the composition, structure, heterogeneity, metabolism, epidemiology, genetics, and function of HDL. Divided into three main parts, High-Density Lipoproteins first examines normal HDL particles, then describes defective HDL, and finally addresses the therapeutic normalization of subnormal levels and defective biological activities of this lipoprotein class. The book highlights the functional properties of HDL, which are relevant to the pathophysiology of atherosclerosis and thrombosis, and discusses the compositional and metabolic heterogeneity of HDL particles. Readers will come away with a clear understanding of the role of HDL in biological processes, the potential value of functional HDL as a therapeutic target, and how current and emerging therapies are poised to influence the treatment of heart disease in the future.
| Author | : Roberta Lugano |
| Publisher | : |
| Total Pages | : 235 |
| Release | : 2013 |
| Genre | : |
| ISBN | : |
High levels of circulating low-density lipoproteins (LDL) are one of the major cardiovascular risk factors. Hypercholesterolemia induces endothelial dysfunction and chronic intimal inflammatory cell accumulation, hallmarks of the initiation of atherosclerosis. Additionally, growing human atherosclerotic plaques show proliferation and migration of vascular smooth muscle cells (VSMC) towards the intima producing remodeling of the vascular wall. However, those plaques that are most prone to rupture show a progressive loss of VSMC becoming soft and vulnerable and these lipid-rich high risk plaques cause clinical episodes resulting in morbid or fatal ischemic events. The mechanisms involved in the transformation of a plaque into a vulnerable VSMC-depleted atheroma have not been completely elucidated. Lipid-rich-VSMC have an impaired vascular repair function due to changes in cytoskeleton proteins. However, the effects of LDL on VSMC function during plaque remodeling and vascular repair are not fully understood. Thus, the aim of this thesis was to investigate early changes directly induced by LDL on VSMC phenotype and function and to identify the molecular mechanisms involved. This thesis demonstrates that the cardiovascular risk of hypercholesterolemia involves the interaction of LDL with VSMC and the regulation at a molecular level of different pathways that converge in the cell's migratory capacity. Migratory function of lipid-loaded VSMC can be restored by inhibition of 3-hydroxy-methylglutaryl coenzyme A (HMG-CoA) through a Rho kinase and myosin light chain phosphatase dependent mechanism. In addition, the studies performed in this thesis show that LDL affect VSMC adhesion, migration and cytoskeleton dynamics through the abrogation of the urokinase-plasminogen activator (uPA)/uPA receptor (uPAR) system function and by modulation of HSP27 phosphorylation and subcellular localization.
| Author | : Michael Shaw |
| Publisher | : Routledge |
| Total Pages | : 424 |
| Release | : 2017-10-05 |
| Genre | : Science |
| ISBN | : 1351435078 |
Explores endogenous lipoprotein particles and their interaction with pharmacological agents. Among the topics are receptor-dependent interactions of lipoproteins with tissues and cell types, their uptake and transport with the vascular endothelium, therapeutic and chemical agents that associate in v
| Author | : Chris J. Packard |
| Publisher | : CRC Press |
| Total Pages | : 254 |
| Release | : 2005-09-08 |
| Genre | : Medical |
| ISBN | : 0203492447 |
New discoveries in genetics, molecular, and cell biology are not only enhancing our understanding of the etiology and progression of disease, but are finding applications in the development of new drugs or the implementation of new kinds of therapy. This book provides an in-depth review of emerging areas in biomedical research at the interface of s
| Author | : Bharat B. Aggarwal |
| Publisher | : CRC Press |
| Total Pages | : 370 |
| Release | : 2014-03-17 |
| Genre | : Medical |
| ISBN | : 1466503858 |
The interaction of immune function and nutrition underlies the low-grade chronic inflammation involved in the etiology of many common obesity-associated and age-related chronic disease conditions. This close interaction is the genesis of the term immunonutrition, which represents a new interdisciplinary field of nutritional and medical research. Immunonutrition: Interactions of Diet, Genetics, and Inflammation introduces the breadth of this field, which implicates nutrition in both immune function and in the etiology, prevention, and treatment of common diseases influenced by inflammation and immune imbalance, including obesity, diabetes, heart disease, asthma, autoimmune diseases, and common forms of cancer. The book begins by reviewing the basic mechanisms of immunity and cellular mechanisms of cytokine activation. It discusses the effects of dietary fat intake and changes in Western diet and lifestyle linked to inflammation. It also describes the interaction of genetics and environment in the modulation of immune function and inflammation, and addresses exercise and skeletal muscle as an endocrine and immune organ. The book reviews the entire spectrum of inflammation and cancer from causation to its role in tumor therapy. It examines abdominal obesity and metabolic diseases, interactions between nutrition and autoimmunity in systemic lupus erythematosus and rheumatoid arthritis, and inflammation associated with type 2 diabetes, heart disease, kidney disease, Alzheimer’s disease, and asthma. Considering potential nutrition-based treatments, the book explores approaches for reducing abdominal obesity, anti-inflammatory effects of phytochemicals, practical strategies for increasing fruit and vegetable intake, and anti-inflammatory properties of spice phytonutrients. In addition, it explores how uninformed food choices related to fats and oils create a balance of tissue-selective signals that produce harmful health outcomes and how to restore a healthy balance.
| Author | : Lester Packer |
| Publisher | : CRC Press |
| Total Pages | : 1023 |
| Release | : 2023-06-14 |
| Genre | : Technology & Engineering |
| ISBN | : 1000946738 |
Probes developments and trends in research and clinical applications of vitamin E, discussing its chemistry and biochemistry and natural occurence in nuts, seeds, whole grains and vegetable and fish-liver oils. The book covers new findings on the role of vitamin E as a biological response modifier.
| Author | : R. D. G. Leslie |
| Publisher | : Cambridge University Press |
| Total Pages | : 514 |
| Release | : 1995-03-09 |
| Genre | : Medical |
| ISBN | : 9780521450294 |
This significant new publication provides a summary and overview of the most recent scientific advances in diabetes research, and highlights the role of these developments in advancing clinical practice. Diabetes is one of the major causes of morbidity and mortality in the developed world, and its prevalence elsewhere is on the increase. It affects in excess of 100 million people worldwide. Recent scientific advances have clarified our understanding of the causes and consequences of this devastating disease. These scientific developments are playing an increasingly important role in clinical practice and could well lead the way to the prevention of complications and even a cure for the disease. An international and authoritative team of authors draws together this knowledge and the most recent developments to provide an up to date account which will benefit researchers and clinicians.
| Author | : A. Crastes de Paulet |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 405 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 1468474278 |
This book contains the proceedings of the ARW NATO Conference on "Action of Free Radicals and Active Forms of Oxygen on Lipoproteins and Membrane Lipids: Cellular Interactions and Atherogenesis", held in Bendor, France, October 5-8,1988. Since the pioneer work of Mc Cord and Fridovitch, growing interest has been focused on the study of the role of oxyradicals role in pathology. This interest is reflected in the exponential increase in the number of papers on free radicals, the success of specialized journals and books on this theme, and the organization of national and international meetings. These meetings have discussed, from.a broad point of view, the problems concerning the mechanisms of production of free radicals, their effects on cell CO!1$tituants (lipids, proteins, nucleic acids) and cell function, the methods of analysis of these phenomena, the pathological states in which free radicals may be involved, natural biological defense systems, and the design of "antiradical" therapies. But it is now well established that the most common target of oxy free radicals are membrane lipids because of their chemical nature (cholesterol in saturation, malonic linkage of polyunsaturated fatty acids (PUFA» and of their regular structural arrangement (monolayers in lipoproteins, bilayers in cell membranes). Thus the analysis of the products resulting from the action of oxy free radicals on PUFA is considered the best tool to indirectly evaluate the effects of tissue peroxidations, although the analytical basis for doing so is very questionable.
| Author | : |
| Publisher | : |
| Total Pages | : 2 |
| Release | : 1984 |
| Genre | : Coronary heart disease |
| ISBN | : |
