Lipids In Protein Misfolding PDF Download
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Author | : Olga Gursky |
Publisher | : Springer |
Total Pages | : 270 |
Release | : 2015-07-06 |
Genre | : Science |
ISBN | : 3319173448 |
Download Lipids in Protein Misfolding Book in PDF, ePub and Kindle
Protein conversion from a water-soluble native conformation to the insoluble aggregates and fibrils, which can deposit in amyloid plaques, underlies more than 20 human diseases, representing a major public health problem and a scientific challenge. Such a conversion is called protein misfolding. Protein misfolding can also involve errors in the topology of the folded proteins and their assembly in lipid membranes. Lipids are found in nearly all amyloid deposits in vivo, and can critically influence protein misfolding in vitro and in vivo in many different ways. This book focuses on recent advances in our understanding of the role of lipids in modulating the misfolding of various proteins. The main emphasis is on the basic biophysical studies that address molecular basis of protein misfolding and amyloid formation, and the role of lipids in this complex process.
Author | : Bruce Alberts |
Publisher | : |
Total Pages | : 0 |
Release | : 2002 |
Genre | : Cytology |
ISBN | : 9780815332183 |
Download Molecular Biology of The Cell Book in PDF, ePub and Kindle
Author | : North Atlantic Treaty Organization. Scientific Affairs Division |
Publisher | : IOS Press |
Total Pages | : 290 |
Release | : 2000 |
Genre | : Biological transport |
ISBN | : 9781586030087 |
Download Protein, Lipid and Membrane Traffic Book in PDF, ePub and Kindle
This text concentrates on the following specific topics: the dynamic character of lipids and proteins in biological membranes; the existence of specific domains in membranes including their visualisation; the molecular mechanisms of intracellular transport of membrane constituents and the involvement of lipid-protein interactions in these processes; protein assembly; structure and folding and transport through membranes; and the intracellular sorting and targeting of individual membrane components as well as different organelles."
Author | : Marina Ramirez-Alvarado |
Publisher | : John Wiley & Sons |
Total Pages | : 1311 |
Release | : 2010-12-01 |
Genre | : Science |
ISBN | : 1118031814 |
Download Protein Misfolding Diseases Book in PDF, ePub and Kindle
An increasingly aging population will add to the number of individuals suffering from amyloid. Protein Misfolding Diseases provides a systematic overview of the current and emerging therapies for these types of protein misfolding diseases, including Alzheimer's, Parkinson's, and Mad Cow. The book emphasizes therapeutics in an amyloid disease context to help students, faculty, scientific researchers, and doctors working with protein misfolding diseases bridge the gap between basic science and pharmaceutical applications to protein misfolding disease.
Author | : Gunnar von Heijne |
Publisher | : R. G. Landes |
Total Pages | : 300 |
Release | : 1997 |
Genre | : Science |
ISBN | : |
Download Membrane Protein Assembly Book in PDF, ePub and Kindle
Author | : |
Publisher | : |
Total Pages | : 504 |
Release | : 2010 |
Genre | : |
ISBN | : |
Download Photoactivated Lipids as Modulators of Membrane Protein Folding Book in PDF, ePub and Kindle
Author | : Rutilio A. Fratti |
Publisher | : Frontiers Media SA |
Total Pages | : 212 |
Release | : 2021-06-30 |
Genre | : Science |
ISBN | : 2889669319 |
Download Effects of Membrane Lipids on Protein Function Book in PDF, ePub and Kindle
Author | : Giovanna Ghirlanda |
Publisher | : Humana Press |
Total Pages | : 246 |
Release | : 2013-08-23 |
Genre | : Science |
ISBN | : 9781627035842 |
Download Membrane Proteins Book in PDF, ePub and Kindle
Focusing on model systems for the study of structure, folding, and association in the membrane, Membrane Proteins: Folding, Association, and Design presents an overview of methods that can be applied to these intricate systems. The volume is divided into four detailed sections, covering association of transmembrane helices, interactions with the lipid bilayer, NMR methods, as well as a variety of engineering approaches. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Membrane Proteins: Folding, Association, and Design serves as an ideal guide for researchers reaching for the tantalizing possibility of designing novel membrane proteins with tailored functionality.
Author | : Jörg H. Kleinschmidt |
Publisher | : Humana |
Total Pages | : 0 |
Release | : 2019-06-25 |
Genre | : Science |
ISBN | : 9781493995110 |
Download Lipid-Protein Interactions Book in PDF, ePub and Kindle
This second edition volume expands all chapters of the previous edition, which have been enhanced to cover the most recent developments, the current state of method research, and applications. Additional protocols were added to examine lipid-protein interactions by mass spectrometry, to use protein microarrays to investigate large sets of various proteins, to study membrane protein dynamics by UV resonance Raman spectroscopy, to analyze peptide-induced pore formation in membranes, and to investigate folding and insertion of membrane proteins. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Lipid-Protein Interactions: Methods and Protocols, Second Edition is an essential resource for all researchers who are interested in obtaining up-to-date and comprehensive information about membrane structure and function.
Author | : Peter Quinn |
Publisher | : Springer Science & Business Media |
Total Pages | : 603 |
Release | : 2008-08-27 |
Genre | : Medical |
ISBN | : 1402088310 |
Download Lipids in Health and Disease Book in PDF, ePub and Kindle
Lipids are functionally versatile molecules. They have evolved from relatively simple hydrocarbons that serve as depot storages of metabolites and barriers to the permeation of solutes into complex compounds that perform a variety of signalling functions in higher organisms. This volume is devoted to the polar lipids and their constituents. We have omitted the neutral lipids like fats and oils because their function is generally to act as deposits of metabolizable substrates. The sterols are also outside the scope of the present volume and the reader is referred to volume 28 of this series which is the subject of cholesterol. The polar lipids are comprised of fatty acids attached to either glycerol or sphingosine. The fatty acids themselves constitute an important reservoir of substrates for conversion into families of signalling and modulating molecules including the eicosanoids amongst which are the prostaglandins, thromboxanes and leucotrienes. The way fatty acid metabolism is regulated in the liver and how fatty acids are desaturated are subjects considered in the first part of this volume. This section also deals with the modulation of protein function and inflammation by unsaturated fatty acids and their derivatives. New insights into the role of fatty acid synthesis and eicosenoid function in tumour progression and metastasis are presented.