Leucine Rich Repeat Kinase 2 Lrrk2 PDF Download
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Author | : Hardy J. Rideout |
Publisher | : Springer |
Total Pages | : 280 |
Release | : 2017-03-28 |
Genre | : Medical |
ISBN | : 3319499696 |
Download Leucine-Rich Repeat Kinase 2 (LRRK2) Book in PDF, ePub and Kindle
This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.
Author | : Hardy J. Rideout |
Publisher | : Springer |
Total Pages | : 0 |
Release | : 2017-04-04 |
Genre | : Medical |
ISBN | : 9783319499673 |
Download Leucine-Rich Repeat Kinase 2 (LRRK2) Book in PDF, ePub and Kindle
This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.
Author | : Andrea Meixner |
Publisher | : |
Total Pages | : 0 |
Release | : 2011 |
Genre | : |
ISBN | : |
Download Leucine-rich Repeat Kinase 2 (Lrrk2) Book in PDF, ePub and Kindle
Author | : Christian Klein |
Publisher | : |
Total Pages | : 95 |
Release | : 2008 |
Genre | : |
ISBN | : |
Download Functional Characterization of Leucine-rich Repeat Kinase 2 (LRRK2) Dimerization Book in PDF, ePub and Kindle
Author | : Colin R Martin |
Publisher | : Academic Press |
Total Pages | : 764 |
Release | : 2020-08-13 |
Genre | : Medical |
ISBN | : 0128159510 |
Download Genetics, Neurology, Behavior, and Diet in Parkinson's Disease Book in PDF, ePub and Kindle
Genetics, Neurology, Behavior, and Diet in Parkinson's Disease: The Neuroscience of Parkinson’s Disease, Volume 2 provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. It fills a much-needed gap as a "one-stop" synopsis of everything to do with the neurology and neuroscience related to Parkinson’s disease—from chemicals and cells to individuals. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. Offers the most comprehensive coverage of a broad range of topics related to Parkinson's disease Serves as a foundational collection for neuroscientists and neurologists on the biology of disease and brain dysfunction Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations Serves as a "one-stop" source for everything you need to know about Parkinson’s disease
Author | : Andrea Meixner |
Publisher | : |
Total Pages | : 218 |
Release | : 2011 |
Genre | : |
ISBN | : |
Download Leucine-rich Repeat Kinase 2 (Lrrk2) Book in PDF, ePub and Kindle
Author | : Md, Frcpc, Frcp (hon), Abdul Qayyum Rana |
Publisher | : BoD – Books on Demand |
Total Pages | : 233 |
Release | : 2014-03-26 |
Genre | : Medical |
ISBN | : 9535112295 |
Download A Synopsis of Parkinson's Disease Book in PDF, ePub and Kindle
Parkinsons disease is a disabling neurological condition with both motor and non-motor symptoms for which no cure is available at this stage. This book is unique in covering the most important topics related to Parkinsons disease. Current research and updates about some non-motor symptoms, as well as surgical treatment of Parkinsons disease, in addition to the long term complications of pharmacological treatments have been presented. This book can be used by physicians, researchers and neuroscientists who want to learn new information about these topics related to Parkinsons disease. Authors of the individual chapters are well known in their fields and the book has been edited by a world renowned Parkinsons disease expert.
Author | : Veerle Baekelandt |
Publisher | : Academic Press |
Total Pages | : 324 |
Release | : 2017-03-31 |
Genre | : Medical |
ISBN | : 012805266X |
Download Disease-Modifying Targets in Neurodegenerative Disorders Book in PDF, ePub and Kindle
Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies. This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment. Provides a comprehensive overview of how key proteins in neurodegenerative disorders can be used as targets to modify disease progress Summarizes how patients are treated today, providing a glance at future disease management Includes intelligible and informative information that is perfect for non-specialists, medical practitioners, and scientists Written and peer reviewed by outstanding scientists in their respective fields
Author | : Iqra Nazish |
Publisher | : |
Total Pages | : |
Release | : 2020 |
Genre | : |
ISBN | : |
Download Investigating Leucine-rich Repeat Kinase 2 (LRRK2) Function Book in PDF, ePub and Kindle
Author | : L. M. Dunn |
Publisher | : |
Total Pages | : |
Release | : 2011 |
Genre | : |
ISBN | : |
Download Characterisation of Leucine-rich Repeat Kinase-2 Regulation and Kinase Function Book in PDF, ePub and Kindle
Mutations in Leucine-Rich Repeat Kinase 2 (LRRK2) are one of the most common causes of genetic Parkinson's disease (PD), with mutations thought to account for around 5% of all familial cases. LRRK2 is a large protein with a kinase and GTPase domain and multiple protein--protein interaction domains. Regulation of this protein is complex, with GTPase activity known to regulate kinase activity. Similarly, LRRK2 can autophosphorylate and is thought to form a dimer when active. Mutations in LRRK2 are numerous, with the most prevalent mutations occurring in the enzymatic core of this protein. This thesis describes work done to characterise the regulation and functioning of LRRK2, in order to further contribute towards understanding how mutations in this protein can lead to the pathogenesis of PD. Using BlueNative PAGE and glycerol gradient centrifugation, the quaternary structure of LRRK2 was assessed. In vitro kinase assays were used to characterise kinase activity of recombinant LRRK2 and a number of putative kinase substrates were also investigated. Identification of new kinase substrates was attempted and immunoprecipitation of LRRK2 to identify novel binding partners was also performed. Results of these experiments showed that familial mutations do not affect the ability of LRRK2 to form complexes. Instead, some mutations are affecting the enzymatic activity of LRRK2. Dephosphorylating LRRK2 showed that dimer formation is dependent on phosphorylation. Dephosphorylated forms of LRRK2 were more likely to be monomeric and displayed lower kinase activity than higher molecular weight forms. In vitro kinase assays to evaluate LRRK2 kinase substrates showed that [alpha]-synuclein is phosphorylated at low levels by G2019S but not wild-type LRRK2. Attempts to identify novel kinase substrates and binding partners of LRRK2 were unsuccessful, however evaluation of putative kinase substrates in vitro showed that DVL3 and TUBB5 may be good candidates for further investigation, as they were robustly phosphorylated by LRRK2. These results contribute towards our understanding of how LRRK2 functions and future studies based on these results may prove useful in aiding our understanding of how LRRK2 can cause PD pathogenesis.