Isolated perfused organ preparations
Author | : |
Publisher | : |
Total Pages | : 198 |
Release | : 1990 |
Genre | : |
ISBN | : 9783924638573 |
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Author | : |
Publisher | : |
Total Pages | : 198 |
Release | : 1990 |
Genre | : |
ISBN | : 9783924638573 |
Author | : Horace David Ritchie |
Publisher | : |
Total Pages | : 214 |
Release | : 1973 |
Genre | : Isolation perfusion (Physiology) |
ISBN | : 9780258968901 |
Author | : Russell David Spruell |
Publisher | : |
Total Pages | : 132 |
Release | : 1997 |
Genre | : Computerized instruments |
ISBN | : |
Author | : Brian David Ross |
Publisher | : |
Total Pages | : 504 |
Release | : 1972 |
Genre | : Medical |
ISBN | : |
Author | : A. Wallace Hayes |
Publisher | : CRC Press |
Total Pages | : 2296 |
Release | : 2007-09-25 |
Genre | : Medical |
ISBN | : 1420005421 |
Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanis
Author | : Linda Bogar |
Publisher | : Springer |
Total Pages | : 0 |
Release | : 2020-09-10 |
Genre | : Medical |
ISBN | : 9783319580531 |
This work provides a one-of- a-kind volume that includes all aspects of heart transplantation from its historic beginning to its current day standards which now make the procedure a long-term treatment option for heart failure patients. The subjects covered include technical aspects of the procurement and implant procedures, as well as the medical nuances of pre-operative preparation and post-transplant immunosuppression management; the current day multi-disciplinary make up of the transplant team along with information on the keys to building and running a successful transplant program; regulatory standards and listing policies and the impact of the growing mechanical circulatory support technologies on the transplant field; and emerging technologies and future possibilities. All chapters are written by experts in the field and include the most up-to-date peer reviewed studies and clinical guidelines. This book gives an ever-changing reference that will become the text of choice for those beginning or continuing their transplant careers.
Author | : Shayne C. Gad |
Publisher | : CRC Press |
Total Pages | : 419 |
Release | : 2000-11-02 |
Genre | : Medical |
ISBN | : 1560327693 |
Toxicology has made tremendous strides in the sophistication of the models used to identify and understand the mechanisms of agents that can harm or kill humand and other higher organisms. Non-animals or in vitro models started to gain significant use in the 1960s. As a result of the increased concern over animal welfare, economic factors, and the need for greater sensitivity and understanding of mechanisms, interest in in vitro^n models has risen. This volume demonstrates that there now exists a broad range of in vitro models for use in either identifying or understanding most forms of toxicity. The availability of in vitro models spans both the full range of endpoints (irritation, sensitization, lethality, mutagenicity, and devlopmental toxicity) and the full spectrum of target organ systems (skin, eye, heart, liver, kidney, nervous system, etc.). Chapters are devoted to each of these speciality areas from a perspective of presenting the principal models and their uses and limitations. Chapters that overview the principles involved in the general selection and use of models, and that address the issues of safety concerns and regulatory acceptance of these methods are also included.
Author | : Horace David Ritchie |
Publisher | : |
Total Pages | : 232 |
Release | : 1973 |
Genre | : Medical |
ISBN | : |
Author | : William B. Jakoby |
Publisher | : Elsevier |
Total Pages | : 392 |
Release | : 2012-12-02 |
Genre | : Science |
ISBN | : 0323137997 |
Metabolic Basis of Detoxication: Metabolism of Functional Groups considers the possible fates of the relatively circumscribed number of functional groups that xenobiotics bear. An understanding of the possible reactions, and the chemical and biological factors influencing them, will contribute to the overall predictability of the fate of "real" molecules. This approach attempts to knit together the understanding of metabolic pathways with that of the enzymes that catalyze the specific steps. The book contains 18 chapters and begins with a discussion of the biological oxidation of carbon atoms. This is followed by separate chapters on the metabolism of halogenated aliphatic hydrocarbons, aryl halides, heterocyclic rings, alcohols, aldehydes, and ketones. Subsequent chapters cover oxidative processes such as metabolic dealkylations and biological oxidation at nitrogen centers; the reduction of nitro and azo compounds and tertiary amine N-oxides; the oxidation, alkylation, acylation, and glycosylation of mercaptans; epoxide metabolism; and conjugation of phenols. The book aims to inform and interest the pharmacologist and toxicologist concerning the biochemical aspects and to orient the biochemist to the pharmacological insights required in dealing with the metabolism of xenobiotics.
Author | : Hans Vogel |
Publisher | : Springer Science & Business Media |
Total Pages | : 2118 |
Release | : 2007-10-30 |
Genre | : Medical |
ISBN | : 3540714200 |
The new edition of this successful reference offers both cutting-edge and classic pharmacological methods. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.