Introduction To Pharmacokinetics And Pharmacodynamics PDF Download
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| Author | : Thomas N. Tozer |
| Publisher | : Lippincott Williams & Wilkins |
| Total Pages | : 342 |
| Release | : 2006 |
| Genre | : Medical |
| ISBN | : 9780781751490 |
Download Introduction to Pharmacokinetics and Pharmacodynamics Book in PDF, ePub and Kindle
This unique text helps students and healthcare professionals master the fundamentals of pharmacokinetics and pharmacodynamics. Written by distinguished international experts, it provides readers with an introduction to the basic principles underlying the establishment and individualization of dosage regimens and their optimal use in drug therapy. Up-to-date examples featuring currently prescribed drugs illustrate how pharmacokinetics and pharmacodynamics relate to contemporary drug therapy. Study problems at the end of each chapter help students and professionals gain a firm grasp of the material covered within the text.
| Author | : Sara E. Rosenbaum |
| Publisher | : John Wiley & Sons |
| Total Pages | : 576 |
| Release | : 2016-11-22 |
| Genre | : Medical |
| ISBN | : 1119143160 |
Download Basic Pharmacokinetics and Pharmacodynamics Book in PDF, ePub and Kindle
Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also features interactive computer simulations for students to experiment and observe PK/PD models in action. • Presents the essentials of pharmacokinetics and pharmacodynamics in a clear and progressive manner • Helps students better appreciate important concepts and gain a greater understanding of the mechanism of action of drugs by reinforcing practical applications in both the book and the computer modules • Features interactive computer simulations, available online through a companion website at: https://web.uri.edu/pharmacy/research/rosenbaum/sims/ • Adds new chapters on physiologically based pharmacokinetic models, predicting drug-drug interactions, and pharmacogenetics while also strengthening original chapters to better prepare students for more advanced applications • Reviews of the 1st edition: “This is an ideal textbook for those starting out … and also for use as a reference book …." (International Society for the Study of Xenobiotics) and “I could recommend Rosenbaum’s book for pharmacology students because it is written from a perspective of drug action . . . Overall, this is a well-written introduction to PK/PD …. “ (British Toxicology Society Newsletter)
| Author | : Robert C. Bast, Jr. |
| Publisher | : John Wiley & Sons |
| Total Pages | : 2008 |
| Release | : 2017-03-10 |
| Genre | : Medical |
| ISBN | : 111900084X |
Download Holland-Frei Cancer Medicine Book in PDF, ePub and Kindle
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
| Author | : Sara E. Rosenbaum |
| Publisher | : John Wiley & Sons |
| Total Pages | : 440 |
| Release | : 2012-09-10 |
| Genre | : Medical |
| ISBN | : 111819778X |
Download Basic Pharmacokinetics and Pharmacodynamics Book in PDF, ePub and Kindle
With its clear, straightforward presentation, this text enables you to grasp all the fundamental concepts of pharmacokinetics and pharmacodynamics. This will allow you to understand the time course of drug response and dosing regimen design. Clinical models for concentration and response are described and built from the basic concepts presented in earlier chapters. Your understanding of the material will be enhanced by guided computer exercises conducted on a companion website. Simulations will allow you to visualize drug behavior, experiment with different dosing regimens, and observe the influence of patient characteristics and model parameters. This makes the book ideal for self-study. By including clinical models of agonism, indirect drug effects, tolerance, signal transduction, and disease progression, author Sara Rosenbaum has created a work that stands out among introductory-level textbooks in this area.You'll find several features throughout the text to help you better understand and apply key concepts: Three fictitious drugs are used throughout the text to progressively illustrate the development and application of pharmacokinetic and pharmacodynamic principles Exercises at the end of each chapter reinforce the concepts and provide the opportunity to perform and solve common dosing problems Detailed instructions let you create custom Excel worksheets to perform simple pharmacokinetic analyses Because this is an introductory textbook, the material is presented as simply as possible. As a result, you'll find it easy to gain an accurate, working knowledge of all the core principles, apply them to optimize dosing regimens, and evaluate the clinical pharmacokinetic and pharmacodynamic literature.
| Author | : Hartmut Derendorf |
| Publisher | : Lippincott Williams & Wilkins |
| Total Pages | : 864 |
| Release | : 2019-07-11 |
| Genre | : Medical |
| ISBN | : 1496385896 |
Download Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications Book in PDF, ePub and Kindle
Updated with the latest clinical advances, Rowland and Tozer’s Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition , explains the relationship between drug administration and drug response, taking a conceptual approach that emphasizes clinical application rather than science and mathematics. Bringing a real-life perspective to the topic, the book simplifies concepts and gives readers the knowledge they need to better evaluate drug applications.
| Author | : Sara E. Rosenbaum |
| Publisher | : John Wiley & Sons |
| Total Pages | : 589 |
| Release | : 2016-12-27 |
| Genre | : Medical |
| ISBN | : 1119143152 |
Download Basic Pharmacokinetics and Pharmacodynamics Book in PDF, ePub and Kindle
Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also features interactive computer simulations for students to experiment and observe PK/PD models in action. • Presents the essentials of pharmacokinetics and pharmacodynamics in a clear and progressive manner • Helps students better appreciate important concepts and gain a greater understanding of the mechanism of action of drugs by reinforcing practical applications in both the book and the computer modules • Features interactive computer simulations, available online through a companion website at: https://web.uri.edu/pharmacy/research/rosenbaum/sims/ • Adds new chapters on physiologically based pharmacokinetic models, predicting drug-drug interactions, and pharmacogenetics while also strengthening original chapters to better prepare students for more advanced applications • Reviews of the 1st edition: “This is an ideal textbook for those starting out … and also for use as a reference book …." (International Society for the Study of Xenobiotics) and “I could recommend Rosenbaum’s book for pharmacology students because it is written from a perspective of drug action . . . Overall, this is a well-written introduction to PK/PD …. “ (British Toxicology Society Newsletter)
| Author | : Bernd Meibohm |
| Publisher | : John Wiley & Sons |
| Total Pages | : 426 |
| Release | : 2006-12-13 |
| Genre | : Science |
| ISBN | : 3527609520 |
Download Pharmacokinetics and Pharmacodynamics of Biotech Drugs Book in PDF, ePub and Kindle
This first ever coverage of the pharmacokinetic and pharmacodynamic characteristics of biopharmaceuticals meets the need for a comprehensive book in this field. It spans all topics from lead identification right up to final-stage clinical trials. Following an introduction to the role of PK and PD in the development of biotech drugs, the book goes on to cover the basics, including the pharmacokinetics of peptides, monoclonal antibodies, antisense oligonucleotides, as well as viral and non-viral gene delivery vectors. The second section discusses such challenges and opportunities as pulmonary delivery of proteins and peptides, and the delivery of oligonucleotides. The final section considers the integration of PK and PD concepts into the biotech drug development plan, taking as case studies the preclinical and clinical drug development of tasidotin, as well as the examples of cetuximab and pegfilgrastim. The result is vital reading for all pharmaceutical researchers.
| Author | : Alexander A. Vinks |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 467 |
| Release | : 2013-11-23 |
| Genre | : Medical |
| ISBN | : 0387756132 |
Download Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics Book in PDF, ePub and Kindle
Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development. The book will be designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader will be introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, and the translation of in vitro and animal model data to basic research and clinical situations in humans.
| Author | : Thomas N. Tozer |
| Publisher | : LWW |
| Total Pages | : 0 |
| Release | : 2016 |
| Genre | : Drugs |
| ISBN | : 9781451194425 |
Download Essentials of Pharmacokinetics and Pharmacodynamics Book in PDF, ePub and Kindle
Master the fundamentals of pharmacokinetics and pharmacodynamics with the new edition of this unique text. Essentials of Pharmacokinetics and pharmacodynamics, Second Edition (formerly An Introduction to Pharmacokinetics and Pharmacodynamics), contains must-know content for students of pharmacy and medicine, people engaged in drug development and those working in drug regulatory agencies, as well as any health care professional who needs to understand the basic principles upon which quantitative decisions in drug therapy are based. This new edition provides essential information on the link between drug exposure within the body to drug response the key quantitative tools and principles of drug therapy you need to know, without extensive mathematics: up-to-date examples of currently prescribed drugs are particularly relevant to contemporary practice, and study problems in every chapter help you master the information in the text. Features more and updated study problems, including many that follow the multiple-choice format used in licensing examinations. Detailed answers are provided in an appendix to assist the reader in learning the material. The content of all chapters has been updated, and more than 60 new and improved illustrations have been added. Offers expanded content on Qualifying Events an Intravenous Bolus, Physiologic and Physicochemical Determinants of Drug Disposition; Quantifying Events Following an Extravascular Dose, and Physiologic and Physicochemical Determinants of Drug Absorption Gives greater emphasis to protein drugs and physiologic concepts, with clearly organized and updated content. Includes practice questions to reinforce your comprehension of the topics. Emphasizes the integration of basic concepts in each chapter, ensuring that the material builds on knowledge from prior chapters and is presented in the clearest way possible. Book jacket.
| Author | : Bret Berner |
| Publisher | : John Wiley & Sons |
| Total Pages | : 466 |
| Release | : 2021-08-31 |
| Genre | : Medical |
| ISBN | : 1119772737 |
Download Drug Delivery Approaches Book in PDF, ePub and Kindle
Explore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the field Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes. The distinguished editors have included practical and accessible resources that address the biological and delivery approaches to pulmonary and mucosal delivery of drugs. Emergency care settings are also described, with explorations of the relationship between parenteral infusion profiles and PK/PD. The future of drug delivery is addressed via discussions of virtual experiments to elucidate mechanisms and approaches to drug delivery and personalized medicine. Readers will also benefit from the inclusion of: A thorough introduction to the utility of mathematical models in drug development and delivery An exploration of the techniques and applications of physiologically based models to drug delivery Discussions of oral delivery and pharmacokinetic models and oral site-directed delivery A review of integrated transdermal delivery and pharmacokinetics in development An examination of virtual experiment methods for integrating pharmacokinetic, pharmacodynamic, and drug delivery mechanisms Alternative endpoints to pharmacokinetics for topical delivery Perfect for researchers, industrial scientists, graduate students, and postdoctoral students in the area of pharmaceutical science and engineering, Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics will also earn a place in the libraries of formulators, pharmacokineticists, and clinical pharmacologists.
