Intracellular Traffic And Neurodegenerative Disorders PDF Download
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Author | : Peter H. St.George-Hyslop |
Publisher | : Springer Science & Business Media |
Total Pages | : 188 |
Release | : 2009-02-03 |
Genre | : Medical |
ISBN | : 3540879412 |
Download Intracellular Traffic and Neurodegenerative Disorders Book in PDF, ePub and Kindle
Many adult onset neurodegenerative diseases arise from the accumulation of misfolded peptides. This book examines the role sub-cellular trafficking pathways play in the pathological accumulation of these misfolded proteins and in attempts to clear them.
Author | : Nava Segev |
Publisher | : Springer Science & Business Media |
Total Pages | : 459 |
Release | : 2010-05-30 |
Genre | : Science |
ISBN | : 038793877X |
Download Trafficking Inside Cells Book in PDF, ePub and Kindle
This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.
Author | : Susan J. Foss |
Publisher | : |
Total Pages | : |
Release | : 2015 |
Genre | : |
ISBN | : |
Download Modeling the Aggregation of Interacting Neurofilaments in the Axon Book in PDF, ePub and Kindle
An axon is a long, thin projection away from a neuron. Axonal transport, a crucial process for the survival of a neuron, is the transport of various organelles and proteins along microtubules, which act as an intracellular highway. Disruptions of axonal transport is associated with many neurodegenerative disorders such as motor neuron diseases (including ALS), Alzheimer's disease, and Huntington's disease. In these diseases, we frequently observe local accumulations of cargoes, which resemble highway traffic jams with pileups of cars. It has been hypothesized that these diseases result from "intracellular traffic jams" caused by the interactions of cargoes. In this thesis, we test this hypothesis using a stochastic model that describes cargoes as interacting particles that switch between different moving and pausing states. Specifically, we apply this model to the transport of neurofilaments. Our results suggest that, although the model can generate traffic jams under certain parameter regimes, these jams may be fundamentally different from those observed in diseases. Another conclusion of this model is that low processivity of the molecular motors that transport neurofilaments help avoid intracellular jams. This explains the evolutionary question, "why is the system is designed this way?".
Author | : Michael S. Wolfe |
Publisher | : Academic Press |
Total Pages | : 561 |
Release | : 2018-03-29 |
Genre | : Medical |
ISBN | : 0128113057 |
Download The Molecular and Cellular Basis of Neurodegenerative Diseases Book in PDF, ePub and Kindle
The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts
Author | : Robert Vink |
Publisher | : University of Adelaide Press |
Total Pages | : 354 |
Release | : 2011 |
Genre | : Medical |
ISBN | : 0987073052 |
Download Magnesium in the Central Nervous System Book in PDF, ePub and Kindle
The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Author | : V.M.-Y. Lee |
Publisher | : Springer Science & Business Media |
Total Pages | : 164 |
Release | : 2013-03-09 |
Genre | : Medical |
ISBN | : 3662040565 |
Download Fatal Attractions: Protein Aggregates in Neurodegenerative Disorders Book in PDF, ePub and Kindle
In this volume are contributions based on a meeting arranged by the WHO and the Fondation IPSEN. The scientists focus on neurodegenerative disorders like Alzheimer's Disease, Chromosome 17-Linked Dementia, Parkinson's Disease and disorders with tauopathies.
Author | : Thomas Curran |
Publisher | : Springer Science & Business Media |
Total Pages | : 171 |
Release | : 2010-12-16 |
Genre | : Medical |
ISBN | : 3642166024 |
Download Two Faces of Evil: Cancer and Neurodegeneration Book in PDF, ePub and Kindle
Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. For the most part, the topics have been viewed as distinct and rarely do opportunities arise for transdisciplinary discussions among experts in both fields. However, cancer and neurodegeneration represent yin-yang counterpoints in the regulation of cell growth, and it is reasonable to hypothesize that key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes
Author | : Dick F. Swaab |
Publisher | : Elsevier |
Total Pages | : 544 |
Release | : 2021-06-15 |
Genre | : Science |
ISBN | : 0128199768 |
Download The Human Hypothalamus Book in PDF, ePub and Kindle
The Hypothalamus is an important area of the brain for understanding a variety of neurological disorders. This volume summarizes for readers the anatomy and physiology of the anterior hypothalamus, to better understand pathology and treatment of hypothalamus related disorders. In addition to anatomy and physiology in humans, cytoarchitecture and chemoarchitecture in rodents is provided. The volume explores the role of the hypothalamus in disorders of eating, sleeping, anxiety, and mood, as well as its role in sexual behavior and gender identity. Coverage includes how Parkinson’s, Alzheimer’s and other neurological disorders relate to the hypothalamus. Reviews the anatomy and physiology of the anterior hypothalamus Provides cytoarchitecture and chemoarchitecture from rodents Discusses hypothalamic related disorders of eating, sleeping, anxiety, and mood Covers how Parkinson’s, Alzheimer’s and other neurological disorders relate to the hypothalamus Explores the role of the hypothalamus in sexual behavior and gender identity
Author | : Vinood B. Patel |
Publisher | : Springer Nature |
Total Pages | : 1173 |
Release | : 2022-10-14 |
Genre | : Medical |
ISBN | : 3031073894 |
Download Biomarkers in Nutrition Book in PDF, ePub and Kindle
This handbook provides an all-inclusive insight into biomarkers assessing the impact of nutrition on human health. The reader will gain insight into the area of circulating body fluid biomarkers, from cardiovascular related markers to liver functional tests. Various biomarkers related to the intake of micronutrient and macronutrients are presented, and the effects of different diets, pesticide exposure and dietary supplements are discussed, so are changes of genetic, cellular and histological variables. This systematic handbook is a must have for biomedical researchers as well as clinicians and pharmacologists, who wish to gain extensive understanding on the analysis of effects of various nutritional and dietary effects on human health, ageing and longevity.
Author | : G. Ali Qureshi |
Publisher | : Elsevier |
Total Pages | : 795 |
Release | : 2007-03-22 |
Genre | : Science |
ISBN | : 0080489494 |
Download Oxidative Stress and Neurodegenerative Disorders Book in PDF, ePub and Kindle
Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders. * Contains the latest information on the subject of neurodegenerative disorders* Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems