Interplay Between Structure And Cell Biomaterial Interactions In Orthopedic Implants PDF Download

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An Introduction to Tissue-Biomaterial Interactions

An Introduction to Tissue-Biomaterial Interactions
Author: Kay C. Dee
Publisher: John Wiley & Sons
Total Pages: 250
Release: 2003-04-14
Genre: Science
ISBN: 0471461121

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An Introduction to Tissue-Biomaterial Interactions acquaints an undergraduate audience with the fundamental biological processes that influence these sophisticated, cutting-edge procedures. Chapters one through three provide more detail about the molecular-level events that happen at the tissue-implant interface, while chapters four through ten explore selected material, biological, and physiological consequences of these events. The importance of the body’s wound-healing response is emphasized throughout. Specific topics covered include:Structure and properties of biomaterials Proteins Protein-surface interactions Blood-biomaterial interactions Inflammation and infection The immune system Biomaterial responses to implantation Biomaterial surface engineering Intimal hyperplasia and osseointegration as examples of tissue-biomaterial interactions The text also provides extensive coverage of the three pertinent interfaces between the body and the biomaterial, between the body and the living cells, and between the cells and the biomaterial that are critical in the development of tissue-engineered products that incorporate living cells within a biomaterial matrix. Ideal for a one-semester, biomedical engineering course, An Introduction to Tissue-Biomaterial Interactions provides a solid framework for understanding today’s and tomorrow’s implantable biomedical devices.


Interactions of Bone with Orthopedic Implants and Possible Failures

Interactions of Bone with Orthopedic Implants and Possible Failures
Author: Amirhossein Goharian
Publisher: Academic Press
Total Pages: 326
Release: 2022-07-20
Genre: Science
ISBN: 0323954111

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Interactions of Bone with Orthopedic Implants and Possible Failures focuses on the mechanical and biological issues that may cause failure of the implant-bone construct. The book provides discussions on the effects of the design, process, surface and other engineering parameters of implants and their interaction with bone tissue. For implant designers, it is highly crucial to know the final effects of what they are designing or aiming to design, along with performance parameters. It is also crucial for orthopedic surgeons to be familiar with the background of the design and process parameters of the implant they will insert in a patient’s body. With the understanding brought forth in this book, surgeons can have better implant options and implant designers can create and develop new implant designs. This book can also help biomechanical and mechanical engineers who are normally dealing with testing and analysis of orthopedic implants examine the biomechanical behavior of the implants and their interaction with bone tissue. Explains interactions, along with possible complications of trauma, joint and spinal implants, and failures of the implant and bone tissue Focuses on issues such as bone loss, defects and resorption at the bone and implant interface Includes case studies of implant failures and discusses the mechanical and biological reasons that would cause failure of bone and implant integration


Biomaterials and Medical Devices

Biomaterials and Medical Devices
Author: Ferdyansyah Mahyudin
Publisher: Springer
Total Pages: 242
Release: 2016-02-26
Genre: Technology & Engineering
ISBN: 3319148451

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This book presents an introduction to biomaterials with the focus on the current development and future direction of biomaterials and medical devices research and development in Indonesia. It is the first biomaterials book written by selected academic and clinical experts experts on biomaterials and medical devices from various institutions and industries in Indonesia. It serves as a reference source for researchers starting new projects, for companies developing and marketing products and for governments setting new policies. Chapter one covers the fundamentals of biomaterials, types of biomaterials, their structures and properties and the relationship between them. Chapter two discusses unconventional processing of biomaterials including nano-hybrid organic-inorganic biomaterials. Chapter three addresses biocompatibility issues including in vitro cytotoxicity, genotoxicity, in vitro cell models, biocompatibility data and its related failure. Chapter four describes degradable biomaterial for medical implants, which include biodegradable polymers, biodegradable metals, degradation assessment techniques and future directions. Chapter five focuses on animal models for biomaterial research, ethics, care and use, implantation study and monitoring and studies on medical implants in animals in Indonesia. Chapter six covers biomimetic bioceramics, natural-based biocomposites and the latest research on natural-based biomaterials in Indonesia. Chapter seven describes recent advances in natural biomaterial from human and animal tissue, its processing and applications. Chapter eight discusses orthopedic applications of biomaterials focusing on most common problems in Indonesia, and surgical intervention and implants. Chapter nine describes biomaterials in dentistry and their development in Indonesia.


The Bone-biomaterial Interface

The Bone-biomaterial Interface
Author: John Edward Davies
Publisher:
Total Pages: 524
Release: 1991
Genre: Medical
ISBN:

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Based on the proceedings of the Bone-Biomaterial Interface Workshop held in Toronto, Canada, December 1990, addresses the questions which have arisen during this period of evolution from inert to active materials in orthopedic, dental, and maxillofacial implants with specific reference to the bone-biomaterial interface. The seven parts of the volume reflect the seven sessions of the workshop, dealing with materials issues, protein adsorption, cell and tissue reactions, mechanical influences on interfacial biology, retrieval analysis, and the industrial context. Annotation copyrighted by Book News, Inc., Portland, OR


Comprehensive Biomaterials II

Comprehensive Biomaterials II
Author: Kevin Healy
Publisher: Elsevier
Total Pages: 4865
Release: 2017-05-18
Genre: Technology & Engineering
ISBN: 0081006926

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Comprehensive Biomaterials II, Second Edition, Seven Volume Set brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications. Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance, and future prospects Covers all significant emerging technologies in areas such as 3D printing of tissues, organs and scaffolds, cell encapsulation; multimodal delivery, cancer/vaccine - biomaterial applications, neural interface understanding, materials used for in situ imaging, and infection prevention and treatment Effectively describes the many modern aspects of biomaterials from basic science, to clinical applications


Bone Tissue and Cell Response to Nano-Modified Surface Structures

Bone Tissue and Cell Response to Nano-Modified Surface Structures
Author: Gary William Johnston
Publisher:
Total Pages: 182
Release: 2015
Genre:
ISBN: 9781321812510

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Extensive research for biomaterial development and implant technology has focused on the surface of the material used because of the influence the surface has on cellular and tissue response. The events at the tissue-implant interface are known to be altered by physical or chemical modifications to the surface of an implant. Due to advances in nanotechology, there is particular interest in materials and processing techniques that can be engineered to elicit specific biological responses. Electrochemical anodization is a nano-fabrication technique that enables precise nano-structures to be formed on the surface of titanium. The vertically aligned, laterally spaced titanium oxide (TiO2) nanotube arrays that are formed via the electrochemical anodization process allow for controlled nano-geometries to be studied. The advantages of the nanotube structure has be previously been demonstrated to significantly accelerate osteoblast cell growth [1], improve bone-forming functionality [2], and direct mesenchymal stem cell fate [3]. These findings raise questions such as : (i) the optimization of the outer limits of the nano-geometry, (ii) the application of a similar nano-architecture to different materials without such properties, and (iii) the effects of nano-structures in vivo. This work investigated the cell response of nanotube structures that were larger than previously researched, as well as the use of a nanotube structure thin film on the surface of polymer for additional orthopedic applications. In addition, this dissertation investigated in vivo bone tissue response to nano-modified implant surface modifications. In order to examine the bone response the structure and chemistry of the nanotube surface to were modified to distinguish adhesion to bone. It was found the increased bone adhesion observed on the TiO2 nanotube surfaces is dependent on both the nanotube structure and chemistry. These findings may be significant for understanding the interaction between bone tissue and implant surfaces. The understanding of tissue and cell response to surface geometry and chemistry is critical to advance the field of orthopedic surface technology, and to further the understanding of cellular interactions with complex nano-interfaces.


Bone-Grafting Biomaterials

Bone-Grafting Biomaterials
Author: Yoshiki Oshida
Publisher: Walter de Gruyter GmbH & Co KG
Total Pages: 250
Release: 2024-05-06
Genre: Technology & Engineering
ISBN: 3111136698

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Bone augmentation is a procedure to replace and repair fractured bone in extreme circumstances. The materials used in such grafting techniques must be biocompatible and might come from natural bone sources or synthetic materials. This book defines bone augmentation and describes different bone grafting materials, techniques, and applications. Recently developed materials are also explored.


Concepts of Tissue-Biomaterial Interactions

Concepts of Tissue-Biomaterial Interactions
Author: Rena Bizios
Publisher: John Wiley & Sons
Total Pages: 197
Release: 2024-12-05
Genre: Science
ISBN: 1119841003

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Biology and engineering meet in this groundbreaking and growing discipline Biomedical engineering is an established interdisciplinary research and training area, combining various aspects of physiology, biology, materials science and engineering. Biomedical engineering programs and courses are integral parts of pertinent curricula, generating an urgent need for textbooks which can introduce this fundamental subject to new generations of students, researchers and practicing professionals. The textbook Concepts of Tissue-Biomaterial Interactions meets this need with an introduction to the subject. Beginning with various, key, fundamental concepts of cellular biology and the physiology of tissue wound healing (required to understand interactions of tissues and implants) it offers essential information and insight regarding the design of successful biomaterial implants. Concluding with a look at the current forefront and future of the field, it is an indispensable introduction for fundamental and cutting-edge aspects of biomedical engineering applications. Concepts of Tissue-Biomaterial Interactions readers will also find: Introduction to biological aspects such as cell-extracellular matrix interactions and cell-substrate interactions Details regarding various aspects of the process of normal tissue wound healing Current knowledge of tissue wound healing in the presence of implants Examples of pathological complications, including infection Design criteria for biocompatible implants The process of obtaining regulatory approval of new biomaterials and implantable medical devices by pertinent regulatory agencies Implant biomaterial and medical devices: past, present, and future Concepts of Tissue-Biomaterial Interactions is recommended for advanced undergraduate and for graduate students interested in biomedical engineering, biomaterials, tissue engineering, and implantable biomaterials/medical devices, as well as a reference for practicing biomedical engineering professionals.


Polymeric Biomaterials: Structure and function

Polymeric Biomaterials: Structure and function
Author: Severian Dumitriu
Publisher: CRC Press
Total Pages: 922
Release: 2013
Genre: Medical
ISBN: 142009470X

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The third edition of a bestseller, this comprehensive reference presents the latest polymer developments and most up-to-date applications of polymeric biomaterials in medicine. Expanded into two volumes, the first volume covers the structure and properties of synthetic and natural polymers as well as bioresorbable hybrid membranes, drug delivery systems, cell bioassay systems, and electrospinning for regenerative medicine. This substantially larger resource includes state-of-the-art research and successful breakthroughs in applications that have occurred in the last ten years.