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Integrative Pharmacology-based Research on Traditional Medicine: Methodologies, Medical and Pharmacological Applications

Integrative Pharmacology-based Research on Traditional Medicine: Methodologies, Medical and Pharmacological Applications
Author: Hai Yu Xu
Publisher: Frontiers Media SA
Total Pages: 1019
Release: 2023-09-19
Genre: Science
ISBN: 2832535518

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ntegrative Pharmacology can be used to determine the multi-pharmacological effects of traditional medicines such as traditional Chinese medicine (TCM), Kampo, Sa-sang, Ayurveda, etc.). Through qualitative and quantitative pharmacokinetic-pharmacodynamic (PK-PD) correlations among multi-constituents and multi-targets, integrating chemical profiling, ADME/PK processes, molecular network calculation and resulting experimental validation, the use of Integrative Pharmacology has become widespread. The data has provided a novel paradigm to evaluate the druggability of bioactive ingredients of herbs or formulae, to decipher the pharmacological mechanisms of drug action and to screen potentially new indications for approved drugs and previously unidentified adverse events. On this basis, Integrative Pharmacology may offer an effective way to test the potential scientific basis for traditional medicines and to assess what roles of traditional medicine can and cannot play in pharmaceuticals.


Network Pharmacology and Traditional Medicine

Network Pharmacology and Traditional Medicine
Author: Shao Li
Publisher: Frontiers Media SA
Total Pages: 438
Release: 2020-10-08
Genre: Medical
ISBN: 2889660400

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.


Pharmacological Research on Traditional Herbal Medicines

Pharmacological Research on Traditional Herbal Medicines
Author: Wantanabe
Publisher: CRC Press
Total Pages: 262
Release: 1999-07-23
Genre: Medical
ISBN: 9789057020544

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This book introduces some of the most pharmacological research on traditional herbal medicines and examines potential and functional applications of these agents in modern healthcare systems. It describes state-of-the-art pharmacological methods of traditional herbal medicines.


Evidence Based Validation of Traditional Medicines

Evidence Based Validation of Traditional Medicines
Author: Subhash C Mandal
Publisher: Springer
Total Pages: 1151
Release: 2021-02-10
Genre: Medical
ISBN: 9789811581267

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The demand for traditional medicines, herbal health products, herbal pharmaceuticals, nutraceuticals, food supplements and herbal cosmetics etc. is increasing globally due to the growing recognition of these products as mainly non-toxic, having lesser side effects, better compatibility with physiological flora, and availability at affordable prices. In the last century, medical science has made incredible advances all over the globe. In spite of global reorganization and a very sound history of traditional uses, the promotion of traditional medicine faces a number of challenges around the globe, primarily in developed nations. Regulation and safety is the high concern for the promotion of traditional medicine. Quality issues and quality control, pharmacogivilane, scientific investigation and validation, intellectual property rights, and biopiracy are some key issues that restrain the advancement of traditional medicine around the globe. This book contains diverse and unique chapters, explaining in detail various subsections like phytomolecule, drug discovery and modern techniques, standardization and validation of traditional medicine, and medicinal plants, safety and regulatory issue of traditional medicine, pharmaceutical excipients from nature, plants for future. The contents of the book will be useful for the academicians, researchers and people working in the area of traditional medicine.


Network Pharmacology

Network Pharmacology
Author: Shao Li
Publisher: Springer Nature
Total Pages: 480
Release: 2021-09-29
Genre: Medical
ISBN: 9811607532

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This book introduces “network pharmacology” as an emerging frontier subject of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology is an original subject of fusion system biology, bioinformatics, network science and other related disciplines. It emphasizes on starting from the overall perspective of the system level and biological networks, the analysis of the laws of molecular association between drugs and their treatment objects, reveals the systematic pharmacological mechanisms of drugs, and guides the research and development of new drugs and clinical diagnosis and treatment. After it was proposed, network pharmacology has been paid attention by researchers, and it has been rapidly developed and widely used. In order to systematically reveal the biological basis of diagnosis and treatment in traditional Chinese medicine and modern medicine, we proposed a new concept of "network target" for the first time, which has become the core theory of "network pharmacology". The core principle of a network target is to construct a biological network that can be used to decipher complex diseases. The network is then used as the therapeutic target, to which multicomponent remedies are applied. This book mainly includes four parts: 1) The concept and theory of network pharmacology; 2) Common analysis methods, databases and software in network pharmacological research; 3) Typical cases of traditional Chinese medicine modernization and modern drug research based on network pharmacology; 4) Network pharmacology practice process based on drugs and diseases.


Ethnopharmacology

Ethnopharmacology
Author: Michael Heinrich
Publisher: John Wiley & Sons
Total Pages: 464
Release: 2015-07-29
Genre: Medical
ISBN: 1118930738

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Ethnopharmacology is one of the world’s fastest-growing scientific disciplines encompassing a diverse range of subjects. It links natural sciences research on medicinal, aromatic and toxic plants with socio-cultural studies and has often been associated with the development of new drugs. The Editors of Ethnopharmacology have assembled an international team of renowned contributors to provide a critical synthesis of the substantial body of new knowledge and evidence on the subject that has emerged over the past decade. Divided into three parts, the book begins with an overview of the subject including a brief history, ethnopharmacological methods, the role of intellectual property protection, key analytical approaches, the role of ethnopharmacology in primary/secondary education and links to biodiversity and ecological research. Part two looks at ethnopharmacological contributions to modern therapeutics across a range of conditions including CNS disorders, cancer, bone and joint health and parasitic diseases. The final part is devoted to regional perspectives covering all continents, providing a state-of-the –art assessment of the status of ethnopharmacological research globally. A comprehensive, critical synthesis of the latest developments in ethnopharmacology. Includes a section devoted to ethnopharmacological contributions to modern therapeutics across a range of conditions. Contributions are from leading international experts in the field. This timely book will prove invaluable for researchers and students across a range of subjects including ethnopharmacology, ethnobotany, medicinal plant research and natural products research. Ethnopharmacology- A Reader is part of the ULLA Series in Pharmaceutical Sciences www.ullapharmsci.org


Chinese Herbal Formulas and Applications

Chinese Herbal Formulas and Applications
Author: John K. Chen
Publisher: AOM Press
Total Pages: 1622
Release: 2009-01-01
Genre: Materia medica
ISBN: 9780974063577

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Companion volume to Chinese Medical Herbology and Pharmacology. This book takes the next step in presenting not only the traditional usage of Chinese herbal formulas, but a combined perspective of the pharmacological effects of formulas themselves with clinically relevant research evidence. As competencies in multiple health care disciplines continue to be raised the need for integrative understandings rise with it. Chinese Herbal Formulas and Applications brings together Chinese Herbal Medicine and expands this with the pharmaceutical effects and clinical research findings to use herbal medicines exclusively or in combination with the allopathic medicine. Enhancing the understanding of herbs and herbal formulas from multiple perspectives, Chinese Herbal Formulas and Applications is a resource for improved patient care and therapeutic outcome. OUTSTANDING FEATURES: Comprehensive explanation of the pharmacology of herbal medicinal formulas, and concurrent uses of herbal formulas and pharmaceuticals Documentation from clinical studies and published research Profiles of the doctors without whom there would be no Chinese medicine: insights into the historical context and backgrounds of those famous individuals who shaped our understanding of disease patterns, treatment strategies and herbal formulas. Contributions from over 100 academic, clinical, research and regulatory professionals who reviewed the text before publication, to complement the work of the authors. PLUS Detailed traditional and modern uses, preparation, administration, dosages, combinations, cautions, contraindications and toxicology. Authors comments are drawn from clinical experience. Appendices on herbal medicine for pregnancy and postpartum care and much more.


Drug Discovery and Evaluation: Methods in Clinical Pharmacology

Drug Discovery and Evaluation: Methods in Clinical Pharmacology
Author: H.Gerhard Vogel
Publisher: Springer Science & Business Media
Total Pages: 576
Release: 2010-12-15
Genre: Medical
ISBN: 3540898905

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Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".


Traditional and Complementary Medicine

Traditional and Complementary Medicine
Author: Cengiz Mordeniz
Publisher: BoD – Books on Demand
Total Pages: 112
Release: 2019-12-11
Genre: Science
ISBN: 1789841836

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Modern medicine has reached a point where the patient is not treated as a biopsychosocial-spiritual being but rather is seen as a virtual identity consisting of laboratory findings and images. More focus is placed on relieving the symptoms instead of curing the disease. Mostly, patients are turned into lifetime medication-dependent individuals. New medicines are needed to overcome the side effects, complications, resistance, and intolerance caused by pharmacological and interventional therapies. In hopes of drug-free and painless alternative treatments with fewer complications, there has been a trend to revisit traditional methods that have been dismissed by modern medicine. Traditional medicine has to be reevaluated with modern scientific methods to complement and integrate with evidence-based modern medicine.