Innate Immune Cell Therapy Of Cancer PDF Download
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| Author | : Asha B. Pillai |
| Publisher | : Frontiers Media SA |
| Total Pages | : 132 |
| Release | : 2023-09-13 |
| Genre | : Science |
| ISBN | : 2832534902 |
Download Innate Immune Cell Therapy of Cancer Book in PDF, ePub and Kindle
Adoptive cellular immunotherapy of cancer, particularly chimeric antigen receptor-transduced T cell (CAR-T) therapies, have enjoyed an explosion of clinical trials and translational and basic research in the past decade. The concept and design of the CAR, though originally intended to optimize targeting of innate natural killer cells (NK cells) to tumor-specific antigens, was laterally applied in the past decade to conventional autologous and later third-party allogeneic T cells with first-in-kind successes in leukemia immunotherapy in both adults and children. This approach also spawned the development of an entire industry focused on cancer immunotherapy, laying the foundation for the current paradigm shifts away from toxic chemo/radiotherapy to immune targeting. Aside from cytokine-release toxicities, specific obstacles plaguing existing CAR-T cell therapies include suboptimal killing by fatigued or senescent autologous patient-derived T cells derived, acquisition of tumor resistance to T-cell based immune therapies, and graft-versus-host disease (GVHD) associated with allogeneic conventional T cell therapies.
| Author | : Mary Poupot-Marsan |
| Publisher | : Frontiers Media SA |
| Total Pages | : 256 |
| Release | : 2024-04-17 |
| Genre | : Medical |
| ISBN | : 2832548040 |
Download New insights into innate immune cell-based immunotherapies in cancer Book in PDF, ePub and Kindle
| Author | : Rong-Fu Wang |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 476 |
| Release | : 2012-02-02 |
| Genre | : Medical |
| ISBN | : 1441999140 |
Download Innate Immune Regulation and Cancer Immunotherapy Book in PDF, ePub and Kindle
Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. However, increasing evidence suggests that tumor-infiltrating immune cells may have a dual function: inhibiting or promoting tumor growth and progression. Although regulatory T (Treg) cells induce immune tolerance by suppressing host immune responses against self- or non self-antigens, thus playing critical roles in preventing autoimmune diseases, they might inhibit antitumor immunity and promote tumor growth. Recent studies demonstrate that elevated proportions of Treg cells are present in various types of cancers and suppress antitumor immunity. Furthermore, tumor-specific Treg cells can inhibit immune responses only when they are exposed to antigens presented by tumor cells. Therefore, Treg cells at tumor sites have detrimental effects on immunotherapy directed to cancer.
| Author | : H. C. Stevenson |
| Publisher | : CRC Press |
| Total Pages | : 272 |
| Release | : 1989-07-17 |
| Genre | : Medical |
| ISBN | : 9780824781118 |
Download Adoptive Cellular Immunotherapy of Cancer Book in PDF, ePub and Kindle
This volume presents the most complicated and powerful cancer biotherapies developed. It provides an overview of human immune system function and the mechanisms by which adoptive cellular immunotherapies (ACI) harnesses the activity. The volume provides a vision on the developments in ACI.
| Author | : Laurence Zitvogel |
| Publisher | : Springer |
| Total Pages | : 700 |
| Release | : 2017-12-13 |
| Genre | : Medical |
| ISBN | : 3319624318 |
Download Oncoimmunology Book in PDF, ePub and Kindle
In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.
| Author | : Catarina R. Almeida |
| Publisher | : Frontiers Media SA |
| Total Pages | : 204 |
| Release | : 2020-03-23 |
| Genre | : |
| ISBN | : 2889635740 |
Download Immunomodulation of Innate Immune Cells Book in PDF, ePub and Kindle
| Author | : Lorenzo Mortara |
| Publisher | : Frontiers Media SA |
| Total Pages | : 166 |
| Release | : 2022-11-15 |
| Genre | : Medical |
| ISBN | : 2832505511 |
Download The Intricate Innate Immune-Cancer Cell Relationship in the Context of Tumor Angiogenesis, Immunity and Microbiota: the Angiogenic Switch in the Tumor Microenvironment as a Key Target for Immunotherapies Book in PDF, ePub and Kindle
| Author | : Mansoor M. Amiji |
| Publisher | : Academic Press |
| Total Pages | : 550 |
| Release | : 2021-08-18 |
| Genre | : Business & Economics |
| ISBN | : 012823637X |
Download Cancer Immunology and Immunotherapy Book in PDF, ePub and Kindle
Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. Nanotechnology-based targeted delivery strategies could improve the delivery efficiency of IO agents as well as provide additional avenues for novel therapeutic and vaccination strategies. Additionally, a number of locally-administered immunogenic scaffolds and therapeutic strategies, such as the use of STING agonist, could benefit from rationally designed biomaterials and delivery approaches. Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Comprehensive treaty covering all aspects of immuno-oncology (IO) Novel strategies for delivery of IO therapeutics and vaccines Forecasting on the future of nanotechnology and drug delivery for IO
| Author | : Jenni Punt |
| Publisher | : Elsevier Inc. Chapters |
| Total Pages | : 27 |
| Release | : 2013-06-04 |
| Genre | : Medical |
| ISBN | : 0128059001 |
Download Cancer Immunotherapy Book in PDF, ePub and Kindle
Once alerted by the innate immune system to the presence of a pathogen or a cellular abnormality, the adaptive immune system responds by activating and expanding antigen-specific B and T lymphocytes. This chapter focuses specifically on the activation and activities of T lymphocytes, which coordinate the adaptive immune response. We open with a description of where and how naïve T cells first encounter antigen. We then examine what factors influence the differentiation of helper CD4+ T lymphocytes into one of several effector subsets, each of which secretes a distinct subset of cytokines. We follow with a discussion of the origin and function of cytotoxic CD8+ T cells, the lymphocyte with the capacity to directly kill tumor cells. We close with a brief summary of the unique challenges that face the adaptive immune system when it tried to mount a response to a tumor.
| Author | : Eitan Yefenof |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 215 |
| Release | : 2007-12-20 |
| Genre | : Medical |
| ISBN | : 140206750X |
Download Innate and Adaptive Immunity in the Tumor Microenvironment Book in PDF, ePub and Kindle
Traditionally, the interplay between cancer cells and host immunity has been studied systemically. Recent studies, however, indicate that the tumor microenvironment is unique in providing both supportive and inhibitory factors that determine the fate of the tumor and its host. This volume compiles reviews on innate and adaptive immune responses at the tumor microenvironment with emphasis on positive and negative outcomes that affect the progression of the disease.
