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The Threat of Pandemic Influenza

The Threat of Pandemic Influenza
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 431
Release: 2005-04-09
Genre: Medical
ISBN: 0309095042

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Public health officials and organizations around the world remain on high alert because of increasing concerns about the prospect of an influenza pandemic, which many experts believe to be inevitable. Moreover, recent problems with the availability and strain-specificity of vaccine for annual flu epidemics in some countries and the rise of pandemic strains of avian flu in disparate geographic regions have alarmed experts about the world's ability to prevent or contain a human pandemic. The workshop summary, The Threat of Pandemic Influenza: Are We Ready? addresses these urgent concerns. The report describes what steps the United States and other countries have taken thus far to prepare for the next outbreak of "killer flu." It also looks at gaps in readiness, including hospitals' inability to absorb a surge of patients and many nations' incapacity to monitor and detect flu outbreaks. The report points to the need for international agreements to share flu vaccine and antiviral stockpiles to ensure that the 88 percent of nations that cannot manufacture or stockpile these products have access to them. It chronicles the toll of the H5N1 strain of avian flu currently circulating among poultry in many parts of Asia, which now accounts for the culling of millions of birds and the death of at least 50 persons. And it compares the costs of preparations with the costs of illness and death that could arise during an outbreak.


Flu

Flu
Author: Gina Kolata
Publisher: Farrar, Straus and Giroux
Total Pages: 378
Release: 2011-04-01
Genre: Social Science
ISBN: 1429979356

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Veteran journalist Gina Kolata's Flu: The Story of the Great Influenza Pandemic of 1918 and the Search for the Virus That Caused It presents a fascinating look at true story of the world's deadliest disease. In 1918, the Great Flu Epidemic felled the young and healthy virtually overnight. An estimated forty million people died as the epidemic raged. Children were left orphaned and families were devastated. As many American soldiers were killed by the 1918 flu as were killed in battle during World War I. And no area of the globe was safe. Eskimos living in remote outposts in the frozen tundra were sickened and killed by the flu in such numbers that entire villages were wiped out. Scientists have recently rediscovered shards of the flu virus frozen in Alaska and preserved in scraps of tissue in a government warehouse. Gina Kolata, an acclaimed reporter for The New York Times, unravels the mystery of this lethal virus with the high drama of a great adventure story. Delving into the history of the flu and previous epidemics, detailing the science and the latest understanding of this mortal disease, Kolata addresses the prospects for a great epidemic recurring, and, most important, what can be done to prevent it.


Pandemic Influenza Preparedness and Response

Pandemic Influenza Preparedness and Response
Author: World Health Organization
Publisher: World Health Organization
Total Pages: 62
Release: 2009
Genre: Medical
ISBN: 9241547685

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This guidance is an update of WHO global influenza preparedness plan: the role of WHO and recommendations for national measures before and during pandemics, published March 2005 (WHO/CDS/CSR/GIP/2005.5).


The Domestic and International Impacts of the 2009-H1N1 Influenza A Pandemic

The Domestic and International Impacts of the 2009-H1N1 Influenza A Pandemic
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 440
Release: 2010-07-04
Genre: Medical
ISBN: 0309146771

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In March and early April 2009, a new, swine-origin 2009-H1N1 influenza A virus emerged in Mexico and the United States. During the first few weeks of surveillance, the virus spread by human-to-human transmission worldwide to over 30 countries. On June 11, 2009, the World Health Organization (WHO) raised the worldwide pandemic alert level to Phase 6 in response to the ongoing global spread of the novel influenza A (H1N1) virus. By October 30, 2009, the H1N1 influenza A had spread to 191 countries and resulted in 5,700 fatalities. A national emergency was declared in the United States and the swine flu joined SARS and the avian flu as pandemics of the 21st century. Vaccination is currently available, but in limited supply, and with a 60 percent effectiveness rate against the virus. The story of how this new influenza virus spread out of Mexico to other parts of North America and then on to Europe, the Far East, and now Australia and the Pacific Rim countries has its origins in the global interconnectedness of travel, trade, and tourism. Given the rapid spread of the virus, the international scientific, public health, security, and policy communities had to mobilize quickly to characterize this unique virus and address its potential effects. The World Health Organization and Centers for Disease Control have played critical roles in the surveillance, detection and responses to the H1N1 virus. The Domestic and International Impacts of the 2009-H1N1 Influenza A Pandemic: Global Challenges, Global Solutions aimed to examine the evolutionary origins of the H1N1 virus and evaluate its potential public health and socioeconomic consequences, while monitoring and mitigating the impact of a fast-moving pandemic. The rapporteurs for this workshop reported on the need for increased and geographically robust global influenza vaccine production capacities; enhanced and sustained interpandemic demand for seasonal influenza vaccines; clear "triggers" for pandemic alert levels; and accelerated research collaboration on new vaccine manufacturing techniques. This book will be an essential guide for healthcare professionals, policymakers, drug manufacturers and investigators.


Exploring Lessons Learned from a Century of Outbreaks

Exploring Lessons Learned from a Century of Outbreaks
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Total Pages: 231
Release: 2019-06-05
Genre: Medical
ISBN: 0309490359

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In November 2018, an ad hoc planning committee at the National Academies of Sciences, Engineering, and Medicine planned two sister workshops held in Washington, DC, to examine the lessons from influenza pandemics and other major outbreaks, understand the extent to which the lessons have been learned, and discuss how they could be applied further to ensure that countries are sufficiently ready for future pandemics. This publication summarizes the presentations and discussions from both workshops.


Influenza

Influenza
Author: Mary Delanghe
Publisher:
Total Pages: 60
Release: 2020-02-09
Genre:
ISBN:

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Which control measures worked, and which didn't, in the great influenza pandemic of 1918? The great influenza pandemic of 1918 is estimated to have killed between 50 and 100 million people. This historical episonde has much to teach us about what works and what doesn't, when dealing with the pandemics of today. Wilfred Kellogg, the head of the California State Board of Health wrote this book in 1919, a few short months after the peak of the pandemic. In it, he evaluates the effectiveness of the different measures that were used (such as face masks, quarantines, etc.). Kellogg compares the death rates in the largest cities in the United States based on which controls were implemented. The sometimes counterintuitive outcomes are discussed. Quotes: "A period of sufficient time has elapsed since the beginning of the epidemic in this country that we can now cease mere speculation and use to advantage the actual experiences of different communities and various large cities, which have gathered accurate data on the epidemic. Some cities closed no gathering places, some closed nearly all, and others adopted an intermediate course." "There is only one explanation for the discrepancy between the case rates and the death rates in that part of the curve for November 23 to November 30, which shows that for two weeks there were about as many deaths occurring as there were cases reported. This would indicate that physicians, in their optimism following the subsidence of the main portion of the epidemic, unconsciously stretched a point in favor of the diagnosis against influenza." "Having Boston's experience before it, in which city closing was not instituted until the peak of the epidemic was reached, Washington closed everything before a dozen cases were known to exist in the city. The obvious conclusion from an inspection of these curves is that closing, at least in large cities, avails little or nothing." "Quarantine of whole communities, either intentional or unintentional, kept the disease out absolutely so long as quarantine was maintained. This is but another proof that the disease is of contact infection. Influenza has, in this way, been kept out of a number of institutions; and from an entire camp, namely, Goat Island Naval Training Station in San Francisco Bay." "New York City, before referred to, as one of those cities that did not prohibit public gatherings, did not use masks either, and its record of deaths is lower than that of any of the other larger cities." "Many instances were observed among hospital attendants where apparently the mask was no protection to the wearers. This was the experience of the San Francisco Hospital, which, during the epidemic, was converted into an influenza hospital. In this institution 78 per cent of the nurses contracted influenza notwithstanding the fact that this is probably the best conducted hospital and under the best discipline of any similar institution in the state." "Another most important reason for the failure of the mask, when universally worn, lies in the fact that the majority of masks worn under compulsory ordinances were not properly made and could not reasonably be expected to have any value whatever. Many instances were observed where the mask consisted of only one or two layers of a very coarse-mesh gauze, and the majority of the masks furnished by the Red Cross, which probably made up the bulk of those used, were undeniably too light and coarse in texture to do more than afford a comfortable feeling of safety on the part of the wearer."


Reusability of Facemasks During an Influenza Pandemic

Reusability of Facemasks During an Influenza Pandemic
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 106
Release: 2006-08-24
Genre: Medical
ISBN: 0309101824

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Any strategy to cope with an influenza pandemic must be based on the knowledge and tools that are available at the time an epidemic may occur. In the near term, when we lack an adequate supply of vaccine and antiviral medication, strategies that rely on social distancing and physical barriers will be relatively more prominent as means to prevent spread of disease. The use of respirators and facemasks is one key part of a larger strategy to establish barriers and increase distance between infected and uninfected individuals. Respirators and facemasks may have a role in both clinical care and community settings. Reusability of Facemasks During an Influenza Pandemic: Facing the Flu answers a specific question about the role of respirators and facemasks to reduce the spread of flu: Can respirators and facemasks that are designed to be disposable be reused safely and effectively? The committee-assisted by outstanding staff-worked intensively to review the pertinent literature; consult with manufacturers, researchers, and medical specialists; and apply their expert judgment. This report offers findings and recommendations based on the evidence, pointing to actions that are appropriate now and to lines of research that can better inform future decisions.


Preparing for an Influenza Pandemic

Preparing for an Influenza Pandemic
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 206
Release: 2007-12-28
Genre: Medical
ISBN: 0309110467

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During an influenza pandemic, healthcare workers will be on the front lines delivering care to patients and preventing further spread of the disease. As the nation prepares for pandemic influenza, multiple avenues for protecting the health of the public are being carefully considered, ranging from rapid development of appropriate vaccines to quarantine plans should the need arise for their implementation. One vital aspect of pandemic influenza planning is the use of personal protective equipment (PPE)-the respirators, gowns, gloves, face shields, eye protection, and other equipment that will be used by healthcare workers and others in their day-to-day patient care responsibilities. However, efforts to appropriately protect healthcare workers from illness or from infecting their families and their patients are greatly hindered by the paucity of data on the transmission of influenza and the challenges associated with training and equipping healthcare workers with effective personal protective equipment. Due to this lack of knowledge on influenza transmission, it is not possible at the present time to definitively inform healthcare workers about what PPE is critical and what level of protection this equipment will provide in a pandemic. The outbreaks of severe acute respiratory syndrome (SARS) in 2003 have underscored the importance of protecting healthcare workers from infectious agents. The surge capacity that will be required to reduce mortality from a pandemic cannot be met if healthcare workers are themselves ill or are absent due to concerns about PPE efficacy. The IOM committee determined that there is an urgent need to address the lack of preparedness regarding effective PPE for use in an influenza pandemic. Preparing for an Influenza Pandemic : Personal Protective Equipment for Healthcare Workers identifies that require expeditious research and policy action: (1) Influenza transmission research should become an immediate and short-term research priority so that effective prevention and control strategies can be developed and refined. The current paucity of knowledge significantly hinders prevention efforts. (2) Employer and employee commitment to worker safety and appropriate use of PPE should be strengthened. Healthcare facilities should establish and promote a culture of safety. (3) An integrated effort is needed to understand the PPE requirements of the worker and to develop and utilize innovative materials and technologies to create the next generation of PPE capable of meeting these needs.