Induction Specification And Differentiation Of Neural Crest Cells In Xenopus And Danio Rerio PDF Download
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Author | : Stefanie Dolores Monica |
Publisher | : |
Total Pages | : 92 |
Release | : 2016 |
Genre | : |
ISBN | : |
Download Induction, Specification and Differentiation of Neural Crest Cells in Xenopus and Danio Rerio Book in PDF, ePub and Kindle
The neural crest (NC) is a vertebrate-specific population of multipotent cells, often referred to as the fourth germ layer because of its unique ability to migrate to all parts of the body and contribute to a variety of tissues. Positional information allows neural crest cells to determine their location relative to each other and in complex 3D environments, and to respond accordingly. A central question in developmental biology is how these positional cues are imparted to cells, and how the cells interpret them for the appropriate response. The work in this thesis sets out to determine 1) how Wnt and BMP gradients define cells as neural crest, 2) how the position along the AP axis determines neural crest fate and 3) how abolishing one positional cue results in a craniofacial phenotype. Precise control of BMP and Wnt signaling in both space and time is necessary for proper neural crest induction. While the Wnt signaling pathway has been extensively studied, it is not clear how the cells interpret and respond to the Wnt signals. Knowing the importance of these pathways in setting up the embryo axes, I wanted to further our understanding of the precise way these pathways initiate the neural crest program. An important first step toward determining how the intersection of the Wnt and BMP signaling pathways set up the neural crest cell program in space and time was to develop a method to rapidly and uniformly manipulate the signaling pathways in Xenopu laevis embryos. I was able to validate that small molecules can replace the use of mRNA injections in order to manipulate signaling pathways. The next chapter of my thesis determines how neural crest cells are specified at different axial levels. The derivatives and migratory paths of neural crest cells in the cranial and non-cranial regions are very distinct, so the gene regulatory networks are likely to differ as well. Previous work has focused on the cranial neural crest cells, and therefore, regulation of the non-cranial neural crest program remains poorly understood. By taking advantage of transgenic zebrafish lines, I show that a neural crest cell’s position along the AP axis during early development determines its fate. In the final chapter of this thesis, I examine how abolishing one cue (Wnt signaling) affects patterning of neural crest-derived cells without affecting earlier aspects of neural crest formation, such as proliferation and differentiation. Analysis of the craniofacial structures in mutants for multiple components of non-canonical Wnt signaling provides evidence that each component is required for proper formation in different axes.
Author | : Jean-Pierre Saint-Jeannet |
Publisher | : Springer Science & Business Media |
Total Pages | : 267 |
Release | : 2007-08-10 |
Genre | : Medical |
ISBN | : 0387469540 |
Download Neural Crest Induction and Differentiation Book in PDF, ePub and Kindle
Written by an international panel of recognized leaders in the field, Neural Crest Induction and Differentiation discusses all aspects of modern neural crest biology from its evolutionary significance to its specification, migration, plasticity and contribution to multiple lineages of the vertebrate body, to the pathologies associated with abnormal neural crest development and function. Abundant color figures enhance the text providing clear and attractive illustrations of central issues and concepts.
Author | : Brian K. Hall |
Publisher | : Springer Science & Business Media |
Total Pages | : 410 |
Release | : 2008-12-28 |
Genre | : Science |
ISBN | : 0387098461 |
Download The Neural Crest and Neural Crest Cells in Vertebrate Development and Evolution Book in PDF, ePub and Kindle
A presentation of all aspects of neural crest cell origins (embryological and evolutionary) development and evolution; neural crest cell behavior (migration) and anomalies (neurocristopathies and birth defects) that arise from defective neural crest development. The treatment of development will include discussions of cellular, molecular and genetic aspects of the differentiation and morphogenesis of neural crest cells and structures derived from neural crest cells. The origins of the neural crest in embryology will be discussed using the recent information on the molecular basis of the specification of the neural crest. Also presented are the advances in our understanding of the evolution of jaws from studies on lampreys and of the neural crest from studies on ascidians and amphioxus.
Author | : Peter Thorogood |
Publisher | : |
Total Pages | : 274 |
Release | : 1988 |
Genre | : Bones |
ISBN | : |
Download Craniofacial Development Book in PDF, ePub and Kindle
Author | : Zhiyuan Gong |
Publisher | : World Scientific |
Total Pages | : 684 |
Release | : 2004-11-02 |
Genre | : Science |
ISBN | : 9814482854 |
Download Fish Development And Genetics: The Zebrafish And Medaka Models Book in PDF, ePub and Kindle
The zebrafish is the most important fish model in developmental and genetic analyses. This book contains 19 review articles covering a broad spectrum of topics, from development to genetic tools. The contents range from early development, the role of maternal factors and gastrulation, to tissue differentiation and organogenesis, such as development of the organizer, notochord, floor plate, nervous system, somites, muscle, skeleton and endoderm. The genetic tools cover morpholino knock-down, transgenics, fish cloning, transposons and genome evolution. The book also includes two chapters on genome mapping and embryonic stem cells in medaka, another important model fish. Summarizing the state-of-the-art studies of the zebrafish model and focusing on the molecular aspects of development, this book is a valuable reference for students learning the basic aspects of the zebrafish model, and for researchers seeking resources in zebrafish research.
Author | : |
Publisher | : Academic Press |
Total Pages | : 423 |
Release | : 2009-11-30 |
Genre | : Science |
ISBN | : 0080962823 |
Download Primary Cilia Book in PDF, ePub and Kindle
In recent years, the role of cilia in the study of health, development and disease has been increasingly clear, and new discoveries have made this an exciting and important field of research. This comprehensive volume, a complement to the new three-volume treatment of cilia and flagella by King and Pazour, presents easy-to-follow protocols and detailed background information for researchers working with cilia and flagella. Covers protocols for primary cilia across several systems and species Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time Relevant to clinicians and scientists working in a wide range of fields
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 348 |
Release | : 2000-12-21 |
Genre | : Nature |
ISBN | : 0309070864 |
Download Scientific Frontiers in Developmental Toxicology and Risk Assessment Book in PDF, ePub and Kindle
Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Author | : Lilianna Solnica-Krezel |
Publisher | : Springer |
Total Pages | : 438 |
Release | : 2012-11-28 |
Genre | : Science |
ISBN | : 9783642536670 |
Download Pattern Formation in Zebrafish Book in PDF, ePub and Kindle
Authored by leading experts in the field, this book provides the first comprehensive overview of the mechanisms of early patterning and morphogenesis in zebrafish. It summarizes the current knowledge and the key questions for the next decade of research.
Author | : Anthony Atala |
Publisher | : Academic Press |
Total Pages | : 1076 |
Release | : 2012-12-31 |
Genre | : Technology & Engineering |
ISBN | : 0123859433 |
Download Handbook of Stem Cells Book in PDF, ePub and Kindle
New discoveries in the field of stem cells increasingly dominate the news and scientific literature revealing an avalanche of new knowledge and research tools that are producing therapies for cancer, heart disease, diabetes, and a wide variety of other diseases that afflict humanity. The Handbook of Stem Cells integrates this exciting area of life science, combining in two volumes the requisites for a general understanding of adult and embryonic stem cells. Organized in two volumes entitled Pluripotent Stem Cells and Cell Biology and Adult and Fetal Stem Cells, this work contains contributions from the world’s experts in stem cell research to provide a description of the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations as well as a the latest information of what is known about each specific organ system. Provides comprehensive coverage on this highly topical subject Contains contributions by the foremost authorities and premiere names in the field of stem cell research Companion website - http://booksite.elsevier.com/9780123859426/ - contains over 250 color figures in presentation format
Author | : Malgorzata Kloc |
Publisher | : John Wiley & Sons |
Total Pages | : 459 |
Release | : 2014-06-03 |
Genre | : Science |
ISBN | : 1118492811 |
Download Xenopus Development Book in PDF, ePub and Kindle
Frogs from the genus Xenopus have long been used as model organisms in basic and biomedical research. These frogs have helped unlock key fundamental developmental and cellular processes that have led to important scientific breakthroughs and have had practical application in embryology, cancer research and regenerative medicine. Xenopus Development is a vital resource on the biology and development of these key model organisms, and will be a great tool to researchers using these frogs in various disciplines of biological science. Xenopus Development is divided into four sections, the first three highlight key processes in Xenopus development from embryo to metamophosis. These sections focus on the cellular processes, organogenesis and embryo development. The final section highlights novel techniques and approaches being used in Xenopus research. Providing thorough and detailed coverage, Xenopus Development, will be a timely and welcome volume for those working in cell and molecular biology, genetics, developmental biology and biomedical research. Provides broad overview of the developmental biology of both Xenopus laevis and Xenopus tropicalis Explores cellular to systems development in key biomedical model organisms Timely synthesis of the field of Xenopus biology Highlights key biomedical and basic biological findings unlocked by Xenopus