Immunotherapy Of Hepatocellular Carcinoma PDF Download
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Author | : Tim F. Greten |
Publisher | : Springer |
Total Pages | : 0 |
Release | : 2018-08-22 |
Genre | : Medical |
ISBN | : 9783319879116 |
Download Immunotherapy of Hepatocellular Carcinoma Book in PDF, ePub and Kindle
In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.
Author | : Tim F. Greten |
Publisher | : Springer |
Total Pages | : 170 |
Release | : 2017-10-04 |
Genre | : Medical |
ISBN | : 3319649582 |
Download Immunotherapy of Hepatocellular Carcinoma Book in PDF, ePub and Kindle
In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.
Author | : Weijia Fang |
Publisher | : Frontiers Media SA |
Total Pages | : 127 |
Release | : 2021-08-03 |
Genre | : Medical |
ISBN | : 288971134X |
Download Immunotherapy in Hepatocellular Carcinoma Book in PDF, ePub and Kindle
Author | : Yujin Hoshida |
Publisher | : Springer |
Total Pages | : 366 |
Release | : 2019-08-05 |
Genre | : Medical |
ISBN | : 3030215407 |
Download Hepatocellular Carcinoma Book in PDF, ePub and Kindle
This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.
Author | : |
Publisher | : Academic Press |
Total Pages | : 288 |
Release | : 2019-07-13 |
Genre | : Medical |
ISBN | : 0128173173 |
Download Drug-Induced Liver Injury Book in PDF, ePub and Kindle
Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series
Author | : Brian I. Carr |
Publisher | : Springer Science & Business Media |
Total Pages | : 752 |
Release | : 2009-10-03 |
Genre | : Medical |
ISBN | : 160327376X |
Download Hepatocellular Carcinoma Book in PDF, ePub and Kindle
Hepatocellular cancer is the fifth most common cancer, with 600,000 new cases reported each year worldwide. Additionally, exciting changes in the science of HCC in the last four years have turned the practice of diagnosing and treating the disease upside down. In Hepatocellular Carcinoma: Diagnosis and Treatment, Second Edition, the leading experts in the field of HCC thoroughly update and expand upon the critically acclaimed first edition with all the latest developments in the diagnosis and treatment of primary liver cancer. The book details for physicians the diagnostic and therapeutic decision making process for dealing with such problems as incidental tumors in the liver transplant, the role of neo-adjuvant chemotherapy, intra-arterial vs intravenous therapy, the uses of embolization, and the significance of portal vein thrombus. New chapters discuss the introduction into clinical practice of cell cycle growth inhibitors, an expanded knowledge of Genomics and Proteomics, and novel ways of delivering intra-hepatic chemotherapy. This cutting-edge text is a vital resource and must have for today’s hepatologists and medical and surgical oncologists.
Author | : Jacob Zaemes |
Publisher | : |
Total Pages | : 0 |
Release | : 2019 |
Genre | : Medical |
ISBN | : |
Download Immunotherapy and Hepatocellular Carcinoma Book in PDF, ePub and Kindle
The management of hepatocellular carcinoma (HCC) has been transformed by the incorporation of immune checkpoint inhibitor therapy. Compared to traditional chemotherapy, these regimens have markedly improved outcomes in patients with HCC. Additionally, they are generally well-tolerated in patients with impaired hepatic function. This chapter will review the landmark trials which have paved the way for the use of ICIs in the treatment of HCC and summarize current consensus on best practices regarding their use in this setting. It will also discuss other prospective uses of immunotherapy for the treatment of HCC currently being investigated, including further incorporation of both checkpoint inhibitor and non-checkpoint inhibitor agents into treatment strategies. Furthermore, it will summarize the existing safety and efficacy data regarding the use of checkpoint inhibitors in patients who have previously undergone liver transplant.
Author | : Pierre-Alain Clavien |
Publisher | : John Wiley & Sons |
Total Pages | : 1039 |
Release | : 2011-09-23 |
Genre | : Medical |
ISBN | : 1444356399 |
Download Malignant Liver Tumors Book in PDF, ePub and Kindle
This comprehensive and critical review of current and established treatment modalities for malignant liver tumors is designed to help you sort through the proliferation of competitive approaches and choose the best treatment options for your patient. Dr. Clavien and his contributors consider all the options – radiological, surgical, pharmaceutical, and emerging/novel therapies – and help you find the best single or combined therapy. Building on the success of the previous edition, this extremely thorough revision: features a new section on Guidelines for Liver Tumors, where you will find specific strategies for treating common liver malignancies; the guidelines were prepared by the Associate Editors and take into account national and international society guidelines reflects actual practice by taking a multidisciplinary approach, with contributions from international experts who have extensive experience with this patient population achieves comprehensive and balanced coverage by having each chapter reviewed by the Editor, Deputy Editor, two Associate Editors, and at least one external reviewer includes 16 new chapters that cover liver anatomy, histologic changes in the liver, epidemiology and natural history of HCC, CCC and colorectal liver metastases, strategies of liver resection, and economic aspects as well as novel therapies facilitates the kind of daily interaction among hepatologists, hepatic surgeons, medical oncologists, radiotherapists, and interventional radiologists that is essential when treating patients with complex liver malignancies In 44 chapters organized into six major sections, the book covers the full range of liver tumors. The perfect blend of evidence and experience, Malignant Liver Tumors: Current and Emerging Therapies, 3rd Edition, illuminates the path to better patient care.
Author | : Per-Ulf Tunn |
Publisher | : Springer Science & Business Media |
Total Pages | : 372 |
Release | : 2008-12-28 |
Genre | : Medical |
ISBN | : 3540779604 |
Download Treatment of Bone and Soft Tissue Sarcomas Book in PDF, ePub and Kindle
Bone and soft tissue sarcomas represent only about 2% of all malignancies; however, their treatment – with the goal of curing the patient while preserving the functionality of the affected body part – can, unlike other malignancies, only be successful with therapy concepts devised by interdisciplinary teams. This volume provides an extensive up-to-date overview of the specific diagnostics and current treatment standards of these rare entities, presenting the various limb-sparing modalities for patients with bone and soft tissue sarcomas with special regard to innovative reconstructive options. The evaluation of quality of life based on validated scores and the individual methods of coping with the illness through creative artistic projects are also acknowledged and integrated in the whole concept.
Author | : Shishir Shetty |
Publisher | : Frontiers Media SA |
Total Pages | : 120 |
Release | : 2021-07-08 |
Genre | : Medical |
ISBN | : 2889669904 |
Download Overcoming the immune microenvironment of hepatocellular cancer Book in PDF, ePub and Kindle