Immunomodulatory Roles Of Tryptophan Metabolites In Inflammation And Cancer PDF Download
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Author | : Juliane Günther |
Publisher | : Frontiers Media SA |
Total Pages | : 225 |
Release | : 2020-09-03 |
Genre | : Medical |
ISBN | : 2889639843 |
Download Immunomodulatory Roles of Tryptophan Metabolites in Inflammation and Cancer Book in PDF, ePub and Kindle
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author | : Atilla Engin |
Publisher | : Humana Press |
Total Pages | : 385 |
Release | : 2015-04-28 |
Genre | : Medical |
ISBN | : 3319156306 |
Download Tryptophan Metabolism: Implications for Biological Processes, Health and Disease Book in PDF, ePub and Kindle
This book discusses the relationship between cellular immunity and tryptophan metabolism, as well as its products, serotonin and melatonin, in the development of several diseases and reappraises the common signal transduction pathways of the neurodegenerative diseases, carcinogenesis, immune tolerance, inflammation, hypersensitivity reactions, neuropsychiatric disorders, in addition to bacterial tryptophan biosynthesis and novel antimicrobials. Tryptophan Metabolism: Implications for Biological Processes, Health and Disease presents fundamental information on tryptophan related metabolic pathways and metabolites, implications of these products for specific biological processes, diseases and conditions. This book focuses on effects of tryptophan metabolites on human health and will appeal to researchers, clinicians and students within this field.
Author | : Sandeep Mittal |
Publisher | : Springer |
Total Pages | : 422 |
Release | : 2015-11-18 |
Genre | : Science |
ISBN | : 3319118706 |
Download Targeting the Broadly Pathogenic Kynurenine Pathway Book in PDF, ePub and Kindle
Tryptophan metabolism via kynurenine pathway plays a critical role in both health and a variety of human diseases. This book highlights the known associations between kynurenine pathway and various disease states, as well as examines the current status of drug development and clinical trials of compounds known to alter tryptophan metabolism. The research plays a critical role in molecular targeted therapies directed at altering the kynurenine pathway of tryptophan metabolism. The initial and rate-limiting step of tryptophan metabolism is mediated by one of two enzymes, tryptophan-2,3-dioxygenase (TDO; predominantly in the liver, but also in the brain) and indoleamine-2,3-dioxygenase (IDO; in a host of tissues in response to immune activation). Targeting the enzymes IDO and TDO, as well as other downstream effectors would therefore be likely to generate novel treatment options that would be helpful in a wide variety of clinical settings. This book provides a unique bridge between basic mechanistic understanding of the role of the kynurenine pathway with translational applications and clinical relevance. It will explore the indications that tryptophan metabolism is a potential biomarker of disease activity, can contribute to local and possibly systemic immune suppression in cancer, and is an attractive target for which a variety of inhibitors are readily available.
Author | : Jana K. Sonner |
Publisher | : |
Total Pages | : |
Release | : 2017 |
Genre | : |
ISBN | : |
Download The Role of Tryptophan Metabolism in Neuroinflammation and Immune Responses to Tumors Book in PDF, ePub and Kindle
Author | : Bharat B. Aggarwal |
Publisher | : Springer |
Total Pages | : 489 |
Release | : 2014-05-12 |
Genre | : Medical |
ISBN | : 3034808372 |
Download Inflammation and Cancer Book in PDF, ePub and Kindle
This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
Author | : Robert Dantzer |
Publisher | : Springer |
Total Pages | : 357 |
Release | : 2016-12-28 |
Genre | : Medical |
ISBN | : 3319511521 |
Download Inflammation-Associated Depression: Evidence, Mechanisms and Implications Book in PDF, ePub and Kindle
Inflammation has invaded the field of psychiatry. The finding that cytokines are elevated in various affective and psychotic disorders brings to the forefront the necessity of identifying the precise research domain criteria (RDoCs) that inflammation is responsible for. This task is certainly the most advanced in major depressive disorders. The reason is that a dearth of clinical and preclinical studies has demonstrated that inflammation can cause symptoms of depression and conversely, cytokine antagonists can attenuate symptoms of depression in medical and psychiatric patients with chronic low grade inflammation. Important knowledge has been gained on the symptom dimensions that inflammation is driving and the mechanisms of action of cytokines in the brain, providing new targets for drug research and development. The aim of the book “Inflammation-Associated Depression” is to present this field of research and its implications in a didactic and comprehensive manner to basic and clinical scientists, psychiatrists, physicians, and students at the graduate level.
Author | : Robert Volpé |
Publisher | : Springer Science & Business Media |
Total Pages | : 508 |
Release | : 1999-06-04 |
Genre | : Medical |
ISBN | : 1592597041 |
Download Autoimmune Endocrinopathies Book in PDF, ePub and Kindle
Dr. Robert Volpé and his distinguished contributors comprehensively review the latest thinking about the theoretical, experimental, and clinical aspects of autoimmune endocrine disorders. These world-renowned experts examine the pathogenesis and immunogenetics of these diseases, discuss the role of sex hormones in autoimmunity, and elucidate the nature of autoantigens. They also provide clinical detail on a wide variety of autoimmune endocrinopathies, including autoimmune thyroid disease, Graves' ophthalmopathy and dermopathy, human insulin-dependent diabetes mellitus, and autoimmune adrenocortical failure. Postpartum autoimmune endocrine syndromes, autoimmune hypophysitis, and the polyglandular autoimmune syndromes are also discussed in detail. Comprehensive and authoritative, Autoimmune Endocrinopathies provides today's most up-to-date understanding of the etiology and pathogenesis of autoimmune endocrine diseases.
Author | : T. W. Stone |
Publisher | : Springer |
Total Pages | : 330 |
Release | : 1989 |
Genre | : Medical |
ISBN | : |
Download Quinolinic Acid & the Kynurenines Book in PDF, ePub and Kindle
Author | : Martin Kohlmeier |
Publisher | : Elsevier |
Total Pages | : 841 |
Release | : 2003-10-01 |
Genre | : Medical |
ISBN | : 0080537898 |
Download Nutrient Metabolism Book in PDF, ePub and Kindle
Nutrient Metabolism defines the molecular fate of nutrients and other dietary compounds in humans, as well as outlining the molecular basis of processes supporting nutrition, such as chemical sensing and appetite control. It focuses on the presentation of nutritional biochemistry; and the reader is given a clear and specific perspective on the events that control utilization of dietary compounds. Slightly over 100 self-contained chapters cover all essential and important nutrients as well as many other dietary compounds with relevance for human health. An essential read for healthcare professionals and researchers in all areas of health and nutrition who want to access the wealth of nutrition knowledge available today in one single source. Key Features * Highly illustrated with relevant chemical structures and metabolic pathways * Foreword by Steven Zeisel, Editor-in-chief of the Journal of Nutritional Biochemistry * First comprehensive work on the subject
Author | : Manzoor M. Khan |
Publisher | : Springer Science & Business Media |
Total Pages | : 275 |
Release | : 2008-12-19 |
Genre | : Medical |
ISBN | : 0387779760 |
Download Immunopharmacology Book in PDF, ePub and Kindle
During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.