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Immediate-Early Genes in the Central Nervous System

Immediate-Early Genes in the Central Nervous System
Author: T.R. Tölle
Publisher: Springer Science & Business Media
Total Pages: 171
Release: 2012-12-06
Genre: Science
ISBN: 3642795625
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Immediate-early genes are believed to be involved in the neuron's ability to con vert short-term synaptic stimulation into long-lasting responses and thus contribute to the adaptive alterations involved in neuronal plasticity. Cellular immediate-early genes share a close structural homology with some viral oncogenes. Recent advances in cellular biology have identified the activation and deactivation of immediate-early genes as molecular mechanisms to control regulated and deregulated growth, cellular differentiation and development. In this view immediate-early genes may function as third messengers in a stimulus transcription cascade transferring extracellular information into changes in target gene transcription, thereby changing the phenotype of neurons. Immediate-Early Genes in the Central Nervous System provides a comprehensive up-to-date overview of current methodology in the research of immediate-early genes and includes a wide range of neurobiological topics, such as regeneration, memory formation, epilepsia and nociception. The contributors to this book have been selected from among the leading experts in their field of research. T.R. TOLLE J. SCHADRACK W. ZIEGLGANSBERGER Contents Immediate-early genes -how immmediate and why early? G./. Evan .............................................. . Immediate-early gene activation as a window on mechanism in the nervous system S.P. Hunt, L.A. McNaughton, R. Jenkins, and W. Wisden. . . . . . . . . .. . . . 18 of immediate-early genes during Differential expression synaptic plasticity, seizures and brain injury suggests specific functions for these molecules in brain neurons M. Dragunow . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . 35 . . . . . . . . . .

Immediate Early Genes and Inducible Transcription Factors in Mapping of the Central Nervous System Function and Dysfunction

Immediate Early Genes and Inducible Transcription Factors in Mapping of the Central Nervous System Function and Dysfunction
Author: L. Kaczmarek
Publisher: Gulf Professional Publishing
Total Pages: 400
Release: 2002-07
Genre: Medical
ISBN: 9780444508355
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This book brings together information about the most widely studied IEG/ITF involved in a variety of neuronal activation. Written by a prominent group of authors, it attempts to unravel the complexity of the phenomena of gene expression in the central nervous system.

Immediate Early Genes in Sensory Processing, Cognitive Performance and Neurological Disorders

Immediate Early Genes in Sensory Processing, Cognitive Performance and Neurological Disorders
Author: Raphael Pinaud
Publisher: Springer Science & Business Media
Total Pages: 298
Release: 2006-11-22
Genre: Medical
ISBN: 0387336044
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This book provides a compilation of the most up-to-date literature on the topic of immediate early genes (IEGs). It reviews and details experiments and theories that challenge the reader to expand their view on how IEG research is currently being used to advance our understanding of static and active brain circuits. In addition, the book explores roles of IEGs in clinical neuropathology.

Involvement of the Immediate Early Genes NGFI-A and Arc in Enriched Environment-induced Plasticity in the Central Nervous System

Involvement of the Immediate Early Genes NGFI-A and Arc in Enriched Environment-induced Plasticity in the Central Nervous System
Author: Raphael Ribeiro Pinaud
Publisher:
Total Pages: 242
Release: 2001
Genre:
ISBN:
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The phenomenon of neural plasticity has been postulated to reflect changes in central nervous system circuitry in order to optimize the collection and/or interpretation of environmental information. The expression of immediate early genes (EEGs) is the first genomic response to environmental cues for change. Many EEGs act as transcription factors, in which case they could regulate the genetic mechanisms involved in more stable changes. Generally, long-term changes in circuit performance are mediated by proteins that result from the expression of late genes. The IEGs, nerve growth factor induced gene-A (NGFI-A) and activity regulated cytoskeletal protein (Arc) are currently under investigation as candidate-plasticity genes. NGFI-A is a nuclear protein that serves as a transcription factor for the Synapsins, a family of genes that has been strongly implicated as markers for neural plasticity. Arc has been hypothesized to mediate locally executed dendritic reconfigurations in response to changes in activity levels. In the present thesis, the response profiles for both these IEGs, along with the late genes growth associated protein-43 (GAP-43) and synapsin I, were evaluated for their role in mediating neural plasticity.

The Mouse Nervous System

The Mouse Nervous System
Author: Charles Watson
Publisher: Academic Press
Total Pages: 815
Release: 2011-11-28
Genre: Science
ISBN: 0123694973
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The Mouse Nervous System provides a comprehensive account of the central nervous system of the mouse. The book is aimed at molecular biologists who need a book that introduces them to the anatomy of the mouse brain and spinal cord, but also takes them into the relevant details of development and organization of the area they have chosen to study. The Mouse Nervous System offers a wealth of new information for experienced anatomists who work on mice. The book serves as a valuable resource for researchers and graduate students in neuroscience. Systematic consideration of the anatomy and connections of all regions of the brain and spinal cord by the authors of the most cited rodent brain atlases A major section (12 chapters) on functional systems related to motor control, sensation, and behavioral and emotional states A detailed analysis of gene expression during development of the forebrain by Luis Puelles, the leading researcher in this area Full coverage of the role of gene expression during development and the new field of genetic neuroanatomy using site-specific recombinases Examples of the use of mouse models in the study of neurological illness

Gene Expression in the Central Nervous System

Gene Expression in the Central Nervous System
Author: Albert C. H. Yu
Publisher: Elsevier
Total Pages: 359
Release: 1995
Genre: Juvenile Nonfiction
ISBN: 0444818529
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Gene expression is an active ongoing process that maintains a functional CNS, as proteins are being made on a continual basis. Processes such as learning and memory, nerve cell repair and regeneration and its response to stress are critically dependent on gene expression. This volume highlights the role of gene expression in normal CNS function, and presents many research methods at the cutting edge of neuroscience, which will provide insight into therapeutic approaches through which the control of gene expression may be used in the treatment of many nervous system diseases.