Year Books of Edward II.
Author | : |
Publisher | : |
Total Pages | : 542 |
Release | : 1914 |
Genre | : Great Britain |
ISBN | : |
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Author | : |
Publisher | : |
Total Pages | : 542 |
Release | : 1914 |
Genre | : Great Britain |
ISBN | : |
Author | : Ying Yuan |
Publisher | : CRC Press |
Total Pages | : 233 |
Release | : 2017-12-19 |
Genre | : Mathematics |
ISBN | : 1315354225 |
Reliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose or schedule may lead to failure in later trials. At the same time, if promising preclinical results do not translate into a real treatment advance, it is important to determine this quickly and terminate the clinical evaluation process to avoid wasting resources. Bayesian Designs for Phase I–II Clinical Trials describes how phase I–II designs can serve as a bridge or protective barrier between preclinical studies and large confirmatory clinical trials. It illustrates many of the severe drawbacks with conventional methods used for early-phase clinical trials and presents numerous Bayesian designs for human clinical trials of new experimental treatment regimes. Written by research leaders from the University of Texas MD Anderson Cancer Center, this book shows how Bayesian designs for early-phase clinical trials can explore, refine, and optimize new experimental treatments. It emphasizes the importance of basing decisions on both efficacy and toxicity.
Author | : Pankaj Bhatt |
Publisher | : S. Chand Publishing |
Total Pages | : 262 |
Release | : |
Genre | : Science |
ISBN | : 8121928362 |
The basic principles are explained with examples from student's daily life situations and every topic is followed by thought-provoking questions. Relevant illustrations have been given, wherever necessary. The language used is simple and lucid which keeps the interest of the students alive till the end of the topic.
Author | : Arthur S. Wightman |
Publisher | : Springer |
Total Pages | : 463 |
Release | : 2013-12-11 |
Genre | : Science |
ISBN | : 3642590330 |
The fourth volume of the Collected Works is devoted to Wigners contribution to physical chemistry, statistical mechanics and solid-state physics. One corner stone was his introduction of what is now called the Wigner function, while his paper on adiabatic perturbations foreshadowed later work on Berry phases. Although few in number, Wigners articles on solid-state physics laid the foundations for the modern theory of the electronic structure of metals.
Author | : Dennis Holley |
Publisher | : Dog Ear Publishing |
Total Pages | : 1016 |
Release | : 2017-06-14 |
Genre | : Science |
ISBN | : 1457554046 |
GENERAL BIOLOGY is an introductory level college biology textbook that provides students with an understandable and engaging encounter with the fundamentals of biology. Written for a two-semester undergraduate course of biology majors and presented as a bound set of two distinct volumes, this reader-friendly textbook(s) is concept driven vs. terminology driven. That is, the book(s) are based on the underlying concepts and principles of biology rather than the strict memorization of biological terms and terminology. Written in a student-centered and conversational style, this educational research-based book(s) connects students to all aspects of biology from the molecular to the biosphere. End-of-chapter questions challenge students to think critically and creatively while incorporating science process skills and biological principles.
Author | : Ulrich Dierkes |
Publisher | : Springer Science & Business Media |
Total Pages | : 435 |
Release | : 2013-03-14 |
Genre | : Mathematics |
ISBN | : 3662087766 |
Minimal Surfaces I is an introduction to the field of minimal surfaces and a presentation of the classical theory as well as of parts of the modern development centered around boundary value problems. Part II deals with the boundary behaviour of minimal surfaces. Part I is particularly apt for students who want to enter this interesting area of analysis and differential geometry which during the last 25 years of mathematical research has been very active and productive. Surveys of various subareas will lead the student to the current frontiers of knowledge and can also be useful to the researcher. The lecturer can easily base courses of one or two semesters on differential geometry on Vol. 1, as many topics are worked out in great detail. Numerous computer-generated illustrations of old and new minimal surfaces are included to support intuition and imagination. Part 2 leads the reader up to the regularity theory for nonlinear elliptic boundary value problems illustrated by a particular and fascinating topic. There is no comparably comprehensive treatment of the problem of boundary regularity of minimal surfaces available in book form. This long-awaited book is a timely and welcome addition to the mathematical literature.
Author | : Warren W. Johnson |
Publisher | : |
Total Pages | : 86 |
Release | : 1978 |
Genre | : Helium |
ISBN | : |
Author | : Thomas Peters |
Publisher | : Springer |
Total Pages | : 244 |
Release | : 2009-11-04 |
Genre | : Science |
ISBN | : 3540490809 |
This series presents critical reviews of the present position and future trends in modern chemical research. It contains short and concise reports on chemistry, each written by the world renowned experts. The volume is still valid and useful after five or ten years. More information, as well as the electronic version of the whole content, is available at: springerlink.com.
Author | : Pausanias |
Publisher | : |
Total Pages | : 696 |
Release | : 1913 |
Genre | : Greece |
ISBN | : |
Author | : U. Lüttge |
Publisher | : Springer Science & Business Media |
Total Pages | : 434 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 3642662277 |
As plant physiology increased steadily in the latter half of the 19th century, problems of absorption and transport of water and of mineral nutrients and problems of the passage of metabolites from one cell to another were investigated, especially in Germany. JUSTUS VON LIEBIG, who was born in Darmstadt in 1803, founded agricultural chemistry and developed the techniques of mineral nutrition in agricul ture during the 70 years of his life. The discovery of plasmolysis by NAGEL! (1851), the investigation of permeability problems of artificial membranes by TRAUBE (1867) and the classical work on osmosis by PFEFFER (1877) laid the foundations for our understanding of soluble substances and osmosis in cell growth and cell mechanisms. Since living membranes were responsible for controlling both water movement and the substances in solution, "permeability" became a major topic for investigation and speculation. The problems then discussed under that heading included passive permeation by diffusion, Donnan equilibrium adjustments, active transport processes and antagonism between ions. In that era, when organelle isolation by differential centrifugation was unknown and the electron microscope had not been invented, the number of cell membranes, their thickness and their composition, were matters for conjecture. The nature of cell surface membranes was deduced with remarkable accuracy from the reactions of cells to substances in solution. In 1895, OVERTON, in U. S. A. , published the hypothesis that membranes were probably lipid in nature because of the greater penetration by substances with higher fat solubility.