Human Brain Proteome PDF Download
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| Author | : |
| Publisher | : Elsevier |
| Total Pages | : 352 |
| Release | : 2004-12-11 |
| Genre | : Medical |
| ISBN | : 9780080522463 |
Download Human Brain Proteome Book in PDF, ePub and Kindle
Proteomics is a systematic approach for studying the identity and function of all proteins expressed in a cell, tissue or organ. New drug targets for diseases are often identified by comparing the proteome of the disease state to the normal state. As a result, proteomics has become increasingly important in the pharmaceutical and biotechnology industries as well as academics. This book contains five sections encompassing the research aspects of proteomics on the brain including the most recent advances in the technology and informatics. It discusses advances in high-throughput proteomic technologies and their application to studying neurological disorders such as Alzheimer’s disease, alcoholism, trauma/stroke, Huntington's disease, and Parkinson's disease. With numerous illustrations to explain the concepts, it provides a comprehensive review on the topic. * Describes the latest databases and techniques for analyzing the data generated by proteomics * Outlines the latest developments in proteomic methods * Provides numerous color illustrations highlighting the application of proteomics to the identification of novel drug targets and biomarkers
| Author | : Eric Bertrand |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 397 |
| Release | : 2007-08-29 |
| Genre | : Science |
| ISBN | : 1402059434 |
Download Subcellular Proteomics Book in PDF, ePub and Kindle
This volume summarizes the new developments that made subcellular proteomics a rapidly expanding area. It examines the different levels of subcellular organization and their specific methodologies. In addition, the book includes coverage of systems biology that deals with the integration of the data derived from these different levels to produce a synthetic description of the cell as a system.
| Author | : Enrique Santamaría |
| Publisher | : Humana |
| Total Pages | : 557 |
| Release | : 2019-08-21 |
| Genre | : Medical |
| ISBN | : 9781493997053 |
Download Cerebrospinal Fluid (CSF) Proteomics Book in PDF, ePub and Kindle
This volume focuses on protein analysis, including a wide range of the use of mass spectrometry and other protein methods within neurobiological disciplines. Chapters cover topics such as cerebrospinal fluid (CSF) processing and biobanking; label-free quantitative proteomics; SWATH; top-down proteomics; and experimental strategies based on other –omics applied to CSF metabolome, lipidome, and microRNAome. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Cerebrospinal Fluid (CSF) Proteomics: Methods and Protocols is a valuable resource for graduate students and post-doctoral fellows interested in learning more about CSF proteotyping. It is also useful to established researchers seeking further insight into this growing field.
| Author | : N. Ulfig |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 145 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 3642594255 |
Download Calcium-Binding Proteins in the Human Developing Brain Book in PDF, ePub and Kindle
"This book is primarily written for neuroscientists who will always be interested in the role of calcium in the internal neuronal environment. The objectives are well met. The authors are credible authorities in the field and are the most appropriate to discuss calcium in neuronal development...Through multiple excellent quality pictures, this book shows evidence of the potential roles of calcium in the modulation of development as well as on the determination of programmed cell death. " Review from Doody's Notes
| Author | : Roger J. W. Truscott |
| Publisher | : John Wiley & Sons |
| Total Pages | : 224 |
| Release | : 2021-04-19 |
| Genre | : Science |
| ISBN | : 3527347283 |
Download Long-lived Proteins in Human Aging and Disease Book in PDF, ePub and Kindle
This authoritative overview on an emerging topic in the molecular life sciences covers all aspects of the aging of (long-lived) proteins. It describes the molecular mechanisms of aging on the protein level, in particular the most common side chain modifications and includes analytical methods to study protein half-life and the accumulation of modifications. Finally, the impact of protein aging on several age-related disases in humans is dissected, and their role in limiting human lifespan is discussed.
| Author | : Ka Wan Li |
| Publisher | : Humana |
| Total Pages | : 218 |
| Release | : 2019-08-06 |
| Genre | : Medical |
| ISBN | : 9781493996612 |
Download Neuroproteomics Book in PDF, ePub and Kindle
This second edition volume expands on the previous edition with updates on the latest techniques used in the field of proteomics. Tissue and cellular proteins are now being analyzed at near proteome-wide levels and mass spectrometers are achieving higher sensitivity and speed, resolution, and accuracy. The chapters in this book cover various new methods used in proteomic workflows such as laser microdissection for spatial proteomics of post-mortem brain tissue, sample preparation in single vessel with FASP and SP3 protocols, the crosslinking mass spectrometry, TMT-MS3 based proteomic with synchronous precursor selection, mass spectrometric data dependent acquisition (DDA) and data independent acquisition (DIA, SWATH) methods, 2D-DIGE, and MALDI Imaging Mass Spectrometry. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Neuroproteomics, Second Edition is a valuable guide that help researchers obtain the finest results from current proteomics platforms.
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 408 |
| Release | : 2019-11-05 |
| Genre | : Science |
| ISBN | : 0128178752 |
Download Molecular Biology of Neurodegenerative Diseases: Visions for the Future Book in PDF, ePub and Kindle
Molecular Biology of Neurodegenerative Diseases: Visions for the Future, Volume 168 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Alzheimer's disease, Prion-like propagation of alpha-synuclein, What - if anything - can we learn about neurodegenerative diseases from yeast?, Mitochondrial rejuvenation and replacement as a novel strategy for treatment of age-related neurodegenerative diseases, Propagation and removal of cerebral amyloid angiopathy, and much more. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field
| Author | : Jörg von Hagen |
| Publisher | : John Wiley & Sons |
| Total Pages | : 498 |
| Release | : 2011-08-24 |
| Genre | : Science |
| ISBN | : 3527644695 |
Download Proteomics Sample Preparation Book in PDF, ePub and Kindle
This long-awaited first guide to sample preparation for proteomics studies overcomes a major bottleneck in this fast growing technique within the molecular life sciences. By addressing the topic from three different angles -- sample, method and aim of the study -- this practical reference has something for every proteomics researcher. Following an introduction to the field, the book looks at sample preparation for specific techniques and applications and finishes with a section on the preparation of sample types. For each method described, a summary of the pros and cons is given, as well as step-by-step protocols adaptable to any specific proteome analysis task.
| Author | : G. Lubec |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 380 |
| Release | : 1999-12-02 |
| Genre | : Medical |
| ISBN | : 9783211833773 |
Download The Molecular Biology of Down Syndrome Book in PDF, ePub and Kindle
This book contains updated reviews and original research work on Down Syndrome focussing on brandnew results in neurobiology, in particular results on gene hunting (subtractive hybridization, differential display) and neurochemistry. The book provides new data such as a subtractive library of Down Syndrome brain showing cDNAs that are overexpressed or downregulated and can be regarded as a source for further research on the preliminary transcriptional data given. A 2D-electrophoretic map of human brain proteins including Down Syndrome brain protein expression established by in-gel-digestion of spots with subsequent MALDI-identification provides the scientific basis for protein work to the neuroscientist. Altogether, the book provides a series of new candidate genes possibly involved in Down Syndrome neurobiology, tools for neuroscience studies on Down Syndrome brain thus serving as a manual and updated views and aspects on Down Syndrome pathobiology.
| Author | : Oscar Alzate |
| Publisher | : CRC Press |
| Total Pages | : 356 |
| Release | : 2009-10-26 |
| Genre | : Medical |
| ISBN | : 1420076264 |
Download Neuroproteomics Book in PDF, ePub and Kindle
In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we beg
