High Dose Chemotherapy With Autologous Bone Marrow Transplantation And Or Peripheral Blood Stem Cell Transplantation For Breast Cancer PDF Download
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Author | : |
Publisher | : |
Total Pages | : 0 |
Release | : 1997 |
Genre | : Bone marrow |
ISBN | : |
Download High-dose Chemotherapy with Autologous Bone Marrow Transplantation And/or Peripheral Blood Stem Cell Transplantation for Breast Cancer Book in PDF, ePub and Kindle
Author | : |
Publisher | : |
Total Pages | : 58 |
Release | : 1994 |
Genre | : Bone marrow |
ISBN | : |
Download Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation Book in PDF, ePub and Kindle
Author | : Jane N. Winter |
Publisher | : Springer Science & Business Media |
Total Pages | : 397 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 1461563496 |
Download Blood Stem Cell Transplantation Book in PDF, ePub and Kindle
Blood Stem Cell Transplantation conveys the excitement that accompanies the newest developments in hematopoietic stem cell transplantation. Some of the applications that stand to impact this field most significantly are based on recent advances in the biological sciences, as demonstrated by the chapters on gene therapy, on the detection of minimal residual disease using molecular techniques, and on the use of radioimmunoconjugates targeting lymphoma and leukemia-associated antigens. Others are the results of clinical observations - e.g., the association between graft-versus-host- disease (GVHD) and durable remissions that have led to creative clinical experiments such as donor leukocyte infusions (DLI). Attempts to unravel the biological events that underlie the responses seen in patients with relapsed chronic myelogenous leukemia treated with DLI are likely to provide the basis for future refinements in this clinical approach. Hopefully, improved response rates and reduced toxicity will result. The power of the immunologic response in controlling malignant disease is underscored in the chapter on post-transplant immunotherapy. The complex immunologic process that results in clinical GVHD may be dissected and engineered to provide clinical benefits that include, in addition to its antineoplastic effects, the amelioration of its clinical manifestations. Better control of GVHD with less global immunosuppression will facilitate the use of mismatched and unrelated donors. This area of investigation perfectly illustrates the continued interplay between the laboratory and the clinic. The continued cross-fertilization of ideas between immunologists, molecular biologists and clinical investigators is likely to yield important advances in this field for years to come. Possible applications of stem cell transplantation continue to grow with the identification of alternative sources of stem cells and the potential to engineer and/or expand the graft. Although the use of unrelated and mismatched donors continues to increase, the possibilities associated with umbilical cord blood transplantation are legion, especially if stem cells can be expanded ex vivo to provide grafts for full-sized adults. Using techniques in which contaminating malignant cells may be eliminated from autografts through positive selection, autologous transplantation may prove highly effective, especially when coupled with post-transplant immunotherapy. Some of these same methodologies have helped facilitate the use of autologous grafts for transplantation in patients with chronic myelogenous leukemia without allogeneic donors. Advances in the supportive care of transplant patients, including the pretransplant identification of those at risk from pulmonary complications and the use of cytokines to speed engraftment, have reduced morbidity and mortality to such a degree that it is appropriate to consider high-dose therapy and stem cell reconstitution in patients with nonmalignant diseases. The impressive advances that have occurred in transplantation for thalassemia are described by pioneers in their area of investigation. The burgeoning field of transplantation for autoimmune disorders, including its immunobiologic basis and soon-to- be-realized clinical potential, is also summarized. Continued progress in the use of high-dose therapy with stem cell rescue for the treatment of pediatric tumors, which derives in part from improved supportive care, is detailed. The sobering voice of the health care economists underscores the necessary limitations to our seemingly unbridled imagination. Cost- consciousness and financial know-how will need to be reflected in future study designs. Given the seemingly endless applications of our technology, strategies to insure its cost-effectiveness will be necessary. Continued financial support for laboratory investigation and for the clinical experiments they generate will be required if we are to go forward. Blood Stem Cell Transplantation lays the foundation for many of these future advances; it is incumbent upon us all to insure its realization.
Author | : Richard A. Rettig |
Publisher | : Oxford University Press |
Total Pages | : 368 |
Release | : 2007-01-25 |
Genre | : Medical |
ISBN | : 0199748241 |
Download False Hope Book in PDF, ePub and Kindle
In the late 1980s, a promising new treatment for breast cancer emerged: high-dose chemotherapy with autologous bone marrow transplantation or HDC/ABMT. By the 1990s, it had burst upon the oncology scene and disseminated rapidly before having been carefully evaluated. By the time published studies showed that the procedure was ineffective, more than 30,000 women had received the treatment, shortening their lives and adding to their suffering. This book tells of the rise and demise of HDC/ABMT for metastatic and early stage breast cancer, and fully explores the story's implications, which go well beyond the immediate procedure, and beyond breast cancer, to how we in the United States evaluate other medical procedures, especially life-saving ones. It details how the factors that drove clinical use--patient demand, physician enthusiasm, media reporting, litigation, economic exploitation, and legislative and administrative mandates--converged to propel the procedure forward despite a lack of proven clinical effectiveness. It also analyzes the limited effect of technology assessments before randomized clinical trials evaluated decisively the procedure and the ramifications of this system on healthcare today. Sections of the book consider the initial conditions surrounding the emergence of the new breast cancer treatment, the drivers of clinical use, and the struggle for evidence-based medicine. A concluding section considers the significance of the story for our healthcare system.
Author | : Angelo Carella |
Publisher | : Routledge |
Total Pages | : 472 |
Release | : 2020-08-26 |
Genre | : Medical |
ISBN | : 1000141322 |
Download Autologous Stem Cell Transplantation Book in PDF, ePub and Kindle
This textbook integrates basic research and clinical aspects underlying the most recent results in those malignant diseases where progress is most effective. Recent evidence shows that higher doses are better in inducing higher cure rates in hematological neoplasias, although myeloblation related to dose intensity can be a limiting factor. The toxicity can now be controlled with autologous marrow and peripheral blood progenitor cell transplantation, used with or without growth factors. The combination of high dose chemoradiotherapy followed by re-infusion of autologous stem cells constitute a dramatic advance in the treatment of refactory and relapse hematological neoplasias.
Author | : Robert J. Soiffer |
Publisher | : Springer Science & Business Media |
Total Pages | : 483 |
Release | : 2004-01-29 |
Genre | : Medical |
ISBN | : 1592597335 |
Download Stem Cell Transplantation for Hematologic Malignancies Book in PDF, ePub and Kindle
A comprehensive survey of the current state-of-the-art in hematopoietic stem cell transplantation for malignant disease. The authors focus on the indications and results of transplantation for acute leukemia, chronic myelogenous leukemia, lymphoma, multiple myeloma, and breast cancer. Special attention is given to transplant-related complications, including the pathophysiology and clinical consequences of acute and chronic GVHD, delayed immune reconstitution leading to infectious complications, and organ damage to the lung and liver. Additional chapters address the sources of stem cells and the effects of graft manipulation used to eliminate residual contaminating tumor cells in autologous transplantation, or to reduce the number of T lymphocytes causing GVHD in allogenic transplantation.
Author | : Wolfgang Schultze |
Publisher | : Wiley-Blackwell |
Total Pages | : 220 |
Release | : 2000-05-25 |
Genre | : Medical |
ISBN | : |
Download High Dose Therapy and Transplantation of Haemopoietic Stem Cells Book in PDF, ePub and Kindle
This book summarizes the most recent findings in the field of high-dose therapy of malignant & non-malignant diseases, both in basic & clinical research. Newly developed methods are included, & emphasis is placed on acute & chronic myeloid & lymphocytic leukemia, multiple myeloma, myelodysplastic syndromes, aplastic anemia & autoimmune disease, & certain solid tumors.
Author | : Robert Peter Gale |
Publisher | : Cambridge University Press |
Total Pages | : 201 |
Release | : 1994-01-28 |
Genre | : Medical |
ISBN | : 0521442109 |
Download Blood Stem Cell Transplants Book in PDF, ePub and Kindle
This well-structured 1994 text provides a comprehensive review of the role of blood stem cell transplantation in cancer treatment.
Author | : C. Dean Buckner |
Publisher | : Springer Science & Business Media |
Total Pages | : 414 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 1461520134 |
Download Technical and Biological Components of Marrow Transplantation Book in PDF, ePub and Kindle
Technical and Biological Components of Marrow Transplantation presents up to date information on the scientific and technological advances that will extend and improve the clinical application of bone marrow transplantation. The book includes the latest information on chronic myeloid leukemia and thalassemia; advances in supportive care: cytokines and progenitor expansion; and cord stem cell technology. Soon more of patients will receive marrow transplants as part of the therapy for solid tumors and metabolic disease than for the treatment of hematologic disease. The contributors to this volume describe some of these applications, hinting at yet further, exciting possibilities.
Author | : James O. Armitage |
Publisher | : |
Total Pages | : 988 |
Release | : 2000 |
Genre | : Medical |
ISBN | : |
Download High-dose Cancer Therapy Book in PDF, ePub and Kindle
A treatise on high-dose cancer therapy.