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Handbook of Carbohydrate-Modifying Biocatalysts

Handbook of Carbohydrate-Modifying Biocatalysts
Author: Peter Grunwald
Publisher: CRC Press
Total Pages: 1056
Release: 2016-11-25
Genre: Medical
ISBN: 1351733974

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This book provides an actual overview of the structure, function, and application of carbohydrate-modifying biocatalysts. Carbohydrates have been disregarded for a long time by the scientific community, mainly due to their complex structure. Meanwhile, the situation changed with increasing knowledge about the key role carbohydrates play in biological processes such as recognition, signal transduction, immune responses, and others. An outcome of research activities in glycoscience is the development of several new pharmaceuticals against serious diseases such as malaria, cancer, and various storage diseases. Furthermore, the employment of carbohydrate-modifying biocatalysts—enzymes as well as microorganisms—will contribute significantly to the development of environmentally friendly processes boosting a shift of the chemical industry from petroleum- to bio-based production of chemicals from renewable resources. The updated content of the second edition of this book has been extended by discussing the current state of the art of using recombinantly expressed carbohydrate-modifying biocatalysts and the synthesis of minicellulosomes in connection with consolidated bioprocessing of lignocellulosic material. Furthermore, a synthetic biology approach for using DAHP-dependent aldolases to catalyze asymmetric aldol reactions is presented.


Carbohydrate-Modifying Biocatalysts

Carbohydrate-Modifying Biocatalysts
Author: Peter Grunwald
Publisher: CRC Press
Total Pages: 832
Release: 2011-10-19
Genre: Medical
ISBN: 9814303488

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Carbohydrates have long been disregarded by the scientific community due to their complex structure and a lack of suitable experimental methods for structure determination. This book provides an overview of the structure, function, and application of carbohydrate-modifying biocatalysts. It explores glycoconjugates and carbohydrate-modifying enzymes


Handbook of Carbohydrate-Modifying Biocatalysts

Handbook of Carbohydrate-Modifying Biocatalysts
Author: Peter Grunwald
Publisher: CRC Press
Total Pages: 1056
Release: 2016-11-25
Genre: Medical
ISBN: 1351733982

Download Handbook of Carbohydrate-Modifying Biocatalysts Book in PDF, ePub and Kindle

This book provides an actual overview of the structure, function, and application of carbohydrate-modifying biocatalysts. Carbohydrates have been disregarded for a long time by the scientific community, mainly due to their complex structure. Meanwhile, the situation changed with increasing knowledge about the key role carbohydrates play in biological processes such as recognition, signal transduction, immune responses, and others. An outcome of research activities in glycoscience is the development of several new pharmaceuticals against serious diseases such as malaria, cancer, and various storage diseases. Furthermore, the employment of carbohydrate-modifying biocatalysts—enzymes as well as microorganisms—will contribute significantly to the development of environmentally friendly processes boosting a shift of the chemical industry from petroleum- to bio-based production of chemicals from renewable resources. The updated content of the second edition of this book has been extended by discussing the current state of the art of using recombinantly expressed carbohydrate-modifying biocatalysts and the synthesis of minicellulosomes in connection with consolidated bioprocessing of lignocellulosic material. Furthermore, a synthetic biology approach for using DAHP-dependent aldolases to catalyze asymmetric aldol reactions is presented.


Pharmaceutical Biocatalysis

Pharmaceutical Biocatalysis
Author: Peter Grunwald
Publisher: CRC Press
Total Pages: 460
Release: 2020-11-01
Genre: Medical
ISBN: 1000067351

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This volume of Pharmaceutical Biocatalysis starts with a discussion on the importance of biocatalytic synthesis approaches for a sustainable and environmentally friendly production of pharmaceuticals and active pharmaceutical ingredients. Among the enzymes discussed in detail with respect to their pharmaceutical relevance are cyclic nucleotide phosphodiesterases playing an important role in modulating signal transduction in various cell types; human DOPA decarboxylase, related to Parkinson's disease and aromatic amino acid decarboxylase deficiency; and phospholipase D enzymes as drug targets. Isocitrate dehydrogenase 1 and 2 mutations are novel therapeutic targets in acute myeloid leukemia. An additional chapter is devoted to the use of enzymes for prodrug activation in cancer therapy. The other topics include small-molecule inhibitors targeting receptor tyrosine kinases in cancer, β-Lactams and related compounds as antibacterials, non-vitamin K oral anticoagulants for the treatment of thromboembolic diseases, and the molecular mechanisms for statin pleiotropy and its clinical relevance in cardiovascular diseases. The last chapter is a review of lysosomal storage disorders with an overview of approved drugs for treating these disorders by enzyme replacement therapy.


Biocatalysis

Biocatalysis
Author: Peter Grunwald
Publisher: World Scientific Publishing Company
Total Pages: 1316
Release: 2017-08-04
Genre: Science
ISBN: 1783269103

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In this Completely Revised and Extended Edition with a significantly enhanced content, all Chapters have been updated considering relevant literature and recent developments until 2016 together with application oriented examples with a focus on Industrial Biocatalysis. Newly treated topics comprise among others systems metabolic engineering approaches, metagenome screening, new tools for pathway engineering, and de-novo computational design as actual research areas in biocatalysis. Information about different aspects of RNA technologies, and completely new Chapters on 'Fluorescent Proteins' and 'Biocatalysis and Nanotechnology' are also included.


Agricultural Biocatalysis

Agricultural Biocatalysis
Author: Peter Jeschke
Publisher: CRC Press
Total Pages: 365
Release: 2022-12-22
Genre: Science
ISBN: 1000635244

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Compiles the recent agricultural-biocatalysis research results by interdisciplinary teams from international institutes for chemistry, biochemistry, biotechnology, and materials and chemical engineering, Investigating important agricultural-biocatalytic topics related to biochemical conversions or bioremediation, modern biological and chemical applications Covers the research on biosynthesis, biocatalysis, and photosynthesis aspects for use in agro-chemistry, including nano-biocatalytic processing, atrazine toxicity, and theoretical studies in biocatalysis and biological processes.


Industrial Biocatalysis

Industrial Biocatalysis
Author: Peter Grunwald
Publisher: CRC Press
Total Pages: 1201
Release: 2014-12-11
Genre: Medical
ISBN: 9814463892

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Biocatalysis has become an essential tool in the chemical industry and is the core of industrial biotechnology, also known as white biotechnology, making use of biocatalysts in terms of enzymes or whole cells in chemical processes as an alternative to chemical catalysts. This shift can be seen in the many areas of daily life where biocatalysts-with


Biocatalysis and Nanotechnology

Biocatalysis and Nanotechnology
Author: Peter Grunwald
Publisher: CRC Press
Total Pages: 836
Release: 2017-10-25
Genre: Medical
ISBN: 1351767550

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Nanobiocatalysis has rapidly developed into a subarea of enzyme biotechnology. It combines the advances in nanotechnology that have generated nanoscale materials of different sizes, shapes, and physicochemical properties, and the excellent characteristics of biocatalysts into an innovative technology. This book provides an overview of the various relations between nanotechnology and biocatalysis. It discusses the fabrication and application of nanomaterials for the immobilization of enzymes used in the sustainable production of goods and chemicals. Nanosupports have several advantages compared with bulk solid materials because of their high surface area, which results in a significantly reduced mass transfer limitation and comparatively high enzyme loading. These characteristics are also of great use for applications in the fields of enzymatic biosensors, biofuel cells, bioelectronics, and photoelectrochemical analyte detection, where conductive nanomaterials improve the rate of electron transfer. The book also presents an overview of nanotoxicology and covers nanostructured enzyme catalysis in organic solvents and its potential application for biodiesel production, probing of enzymatic activity, and identification of enzyme functions of inorganic nanoparticles as enzyme mimics.


Handbook of Carbohydrate Engineering

Handbook of Carbohydrate Engineering
Author: Kevin J. Yarema
Publisher: CRC Press
Total Pages: 944
Release: 2005-05-27
Genre: Medical
ISBN: 1420027638

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The Handbook of Carbohydrate Engineering provides an overview of the basic science, theory, methods, and applications of this broad, interdisciplinary field. The text provides background information along with practical knowledge for current and future research methodologies used in the characterization and synthesis of various carbohydrates. This


Handbook of Industrial Biocatalysis

Handbook of Industrial Biocatalysis
Author: Ching T. Hou
Publisher: CRC Press
Total Pages: 616
Release: 2005-06-09
Genre: Science
ISBN: 1420027964

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Until now, no comprehensive handbook on industrial biocatalysis has been available. Soliciting chapters on virtually every aspect of biocatalysis from international experts most actively researching the field, the Handbook of Industrial Biocatalysis fills this need. The handbook is divided into three sections based on types of substrates. T