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| Author | : Maria-Domenica Cappellini |
| Publisher | : |
| Total Pages | : |
| Release | : 2008 |
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| ISBN | : 9789963623709 |
| Author | : |
| Publisher | : |
| Total Pages | : |
| Release | : 2008 |
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| Author | : |
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| Total Pages | : 111 |
| Release | : 2000 |
| Genre | : Thalassemia |
| ISBN | : 9789963623303 |
| Author | : Chaim Hershko |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 275 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 1461505933 |
Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).
| Author | : Galanello Renzo |
| Publisher | : |
| Total Pages | : 190 |
| Release | : 2003 |
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| ISBN | : 9789963623396 |
Volume 1 of the Prevention Book presents the principles of a programme for the prevention of the thalassaemia and other haemoglobin disorders, including a description of the various types of disorders requiring prenatal diagnosis, the strategies used for carrier screening, and a number of annexes listing upto date epidemiological and mutation data on thalassaemia. This book was written for use in combination with Volume 2, which describes many of the laboratory protocols in great detail.
| Author | : John Porter (Hematologist) |
| Publisher | : |
| Total Pages | : |
| Release | : 2012 |
| Genre | : |
| ISBN | : 9789963717002 |
The multi-organ pathology of the thalassaemias means that the most successful patient treatment programmes involve a number of medical staff, led by paediatricians and haematologists, but including other specialists in a multidisciplinary approach. However, this means that medical professionals not involved in such multidisciplinary groups, including primary care physicians and the staff of Accident and Emergency departments, rarely treat patients with thalassaemia. As a result, their knowledge of how to address acute complications in such patients is extremely limited. This handbook aims to provide a brief evaluation of the situations in which a thalassaemia patient may seek help beyond the specialized environment he/she is used to. The layout of the handbook is intended to enable the medical professional in a busy clinical setting to draw essential information at a glance, supporting rapid, accurate as possible, decisions on how to proceed.
| Author | : Sue Pavord |
| Publisher | : Cambridge University Press |
| Total Pages | : 362 |
| Release | : 2018-02-08 |
| Genre | : Medical |
| ISBN | : 1108548377 |
Understand the rapidly growing complexities of obstetric hematology and high-risk pregnancy management, with experts in the field. Now in its second edition, this comprehensive and essential guide focuses on providing the best support for patients and clinical staff, to prevent serious complications in pregnancy and the post-partum period for both mother and baby. Wide-ranging and detailed, the guide offers discussions on basic principles of best care, through to tackling lesser-known hematological conditions, such as cytopenias and hemoglobinopathies. Updated with color illustrations, cutting-edge research, accurate blood film reproductions, and practical case studies, the revised edition places invaluable advice into everyday context. This unique resource is essential reading for trainees and practitioners in obstetrics, anesthesia, and hematology, as well as midwives, nurses, and laboratory staff. Clarifying difficult procedures for disease prevention, the guide ensures safety when the stakes are high. Reflecting current evidence-based guidelines, the updated volume is key to improving pregnancy outcomes worldwide.
| Author | : D. J. Weatherall |
| Publisher | : |
| Total Pages | : 186 |
| Release | : 1983 |
| Genre | : Medical |
| ISBN | : |
| Author | : Pedro A. de Alarcón |
| Publisher | : Cambridge University Press |
| Total Pages | : 501 |
| Release | : 2021-02-18 |
| Genre | : Medical |
| ISBN | : 1108488986 |
An essential guide to the pathogenesis, diagnosis and management of hematologic problems in the neonate, covering erythrocyte disorders, leukocyte disorders, immunologic disorders and hemostatic disorders. Guidance is practical, including blood test interpretation, advice on transfusions and reference ranges for hematological values.
| Author | : Barbara J. Bain |
| Publisher | : John Wiley & Sons |
| Total Pages | : 448 |
| Release | : 2020-02-28 |
| Genre | : Medical |
| ISBN | : 1119579996 |
An updated, essential guide for the laboratory diagnosis of haemoglobin disorders This revised and updated third edition of Haemoglobinopathy Diagnosis offers a comprehensive review of the practical information needed for an understanding of the laboratory diagnosis of haemoglobin disorders. Written in a concise and approachable format, the book includes an overview of clinical and laboratory features of these disorders. The author focuses on the selection, performance, and interpretation of the tests that are offered by the majority of diagnostic laboratories. The book also explains when more specialist tests are required and explores what specialist referral centres will accomplish. The information on diagnosis is set in a clinical context. The third edition is written by a leading haematologist with a reputation for educational excellence. Designed as a practical resource, the book is filled with illustrative examples and helpful questions that can aide in the retention of the material presented. Additionally, the author includes information on the most recent advances in the field. This important text: • Contains a practical, highly illustrated, approach to the laboratory diagnosis of haemoglobin disorders • Includes “test-yourself” questions and provides an indispensable tool for learning and teaching • Presents new material on antenatal screening/prenatal diagnostic services • Offers myriad self-assessment case studies that are ideal for the trainee Written for trainees and residents in haematology, practicing haematologists, and laboratory scientists, Haemoglobinopathy Diagnosis is an essential reference and learning tool that provides a clear basis for understanding the diagnosis of haemoglobin disorders.
