Guidebook To Protein Toxins And Their Use In Cell Biology PDF Download
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| Author | : Rino Rappuoli |
| Publisher | : OUP Oxford |
| Total Pages | : 278 |
| Release | : 1997-05-29 |
| Genre | : Medical |
| ISBN | : 019154728X |
Download Guidebook to Protein Toxins and Their Use in Cell Biology Book in PDF, ePub and Kindle
Many bacteria, animals, and plants produce toxins that can prove lethal to other organisms. Toxins are a form of "biological warfare" that helps their producer to survive and so confer an evolutionary advantage. They display an extraordinary range of complexity, from the formic acid provided by ants to bacterial proteins composed of thousands of amino acids. This Guidebook considers the more complex protein and peptide toxins and groups them according to their mode of action. Topics covered include: membrane-permeabilizing toxins; toxins affecting signal transduction and protein synthesis; cytoskeleton-affecting toxins; toxins affecting the immune and inflammatory response. This class of biomolecules will be of interest to a wide range of researchers in cell biology, neuroscience, and toxicology.
| Author | : Klaus Aktories |
| Publisher | : John Wiley & Sons |
| Total Pages | : 334 |
| Release | : 2008-09-26 |
| Genre | : Science |
| ISBN | : 3527614605 |
Download Bacterial Toxins Book in PDF, ePub and Kindle
This is a survey of well characterized and recently discovered bacterial protein toxins. Leading investigators of the respective toxins review the various molecular mechanisms of action, ranging from toxin-induced ADP-ribosylation up to membrane perforation by pore-forming toxins. Thy also describe the consequences on host physiology before focusing on potential applications as cell biological and pharmacological tools for research and medical applications. Detailed descriptions of the methodology include the engineering and use of modified and chimeric toxins for better performance. A solid introduction to toxin structure and functions, as well as a valuable source of methodology for researchers in molecular biology, pharmacology and experimental medicine.
| Author | : Joseph E. Alouf |
| Publisher | : Academic Press |
| Total Pages | : 1201 |
| Release | : 2015-05-29 |
| Genre | : Science |
| ISBN | : 0128005890 |
Download The Comprehensive Sourcebook of Bacterial Protein Toxins Book in PDF, ePub and Kindle
The Comprehensive Sourcebook of Bacterial Protein Toxins, Fourth Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content. Descriptions of relevant toxins as well as representative toxins of the main bacterial toxin families to allow for a better comparison between them Focused chapters on toxin applications and common properties or general features of toxins
| Author | : K. Aktories |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 713 |
| Release | : 2013-03-14 |
| Genre | : Medical |
| ISBN | : 3662059711 |
Download Bacterial Protein Toxins Book in PDF, ePub and Kindle
In recent years remarkable progress has been accomplished with respect to our knowledge about bacterial protein toxins. This refers especially to structural aspects of protein toxins but also holds true for genetics, molecular biology and biochemical mechanisms underlying the action of toxins. This volume covers the very current and exciting aspects of up-to-date bacterial toxicology and comprehensively reviews the most important bacterial protein toxins such as the intracellular acting toxins which exhibit enzyme activity, as well as those toxins that interact with cell plasma membranes by damaging the membranes (pore formation) or stimulating cell receptors (superantigens). This is the most current reference work on these important bacterial protein toxins, which are presented from the point of view of different disciplines such as pharmacology, microbiology, cell biology and protein chemistry.
| Author | : Manfred Schmitt |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 264 |
| Release | : 2004-12-10 |
| Genre | : Science |
| ISBN | : 9783540235620 |
Download Microbial Protein Toxins Book in PDF, ePub and Kindle
Since the initial establishment of Robert Koch’s postulates in the nineteenth century, microbial protein toxins have been recognized as a major factor of bacterial and fungal virulence. An increasing number of proteins produced and secreted by various bacteria, yeasts and plants are extremely toxic and most of them developed remarkably "intelligent" strategies to enter, to penetrate and to finally kill a eukaryotic target cell by modifying or blocking essential cellular components. This book describes the strategies employed by protein toxins to render their pro- and eukaryotic producers a selective growth advantage over competitors. In providing an up-to-date overview on the mode of protein toxin actions, it accommodates biomedically and biologically relevant toxin model systems. As a result, it significantly broadens our perspective on biochemical architecture and molecular ploy behind the lethal principles of pro- and eukaryotic toxins.
| Author | : Alistair J. Lax |
| Publisher | : Cambridge University Press |
| Total Pages | : 268 |
| Release | : 2011-04-28 |
| Genre | : Science |
| ISBN | : 9781139443593 |
Download Bacterial Protein Toxins Book in PDF, ePub and Kindle
Bacterial toxins that act inside cells interact very specifically with key components of the cell and some even manipulate the cell in subtle ways for their own purposes. These potent toxins, described in this 2005 book, will be of interest to both microbiologists and cell biologists. Some of these toxins are conventional multidomain toxins that are self-programmed to enter cells. Others are delivered by type III mechanisms, often as a package of potent molecules. The molecular targets for all these toxins mediate signal transduction and the cell cycle to regulate the crucial processes of cell growth, cell division and differentiation. Thus these potent toxins are not only responsible for disease, but also provide a powerful set of tools with which to interrogate the biology of the cell. In addition such toxins may act directly to promote carcinogenesis and hence their study is also of interest in a wider context.
| Author | : Irene Wüthrich |
| Publisher | : |
| Total Pages | : 132 |
| Release | : 2014 |
| Genre | : |
| ISBN | : |
Download Bacterial Protein Toxins Book in PDF, ePub and Kindle
| Author | : Joseph E. Alouf |
| Publisher | : Elsevier |
| Total Pages | : 0 |
| Release | : 2015-06-05 |
| Genre | : Science |
| ISBN | : 9780128001882 |
Download The Comprehensive Sourcebook of Bacterial Protein Toxins Book in PDF, ePub and Kindle
The Comprehensive Sourcebook of Bacterial Protein Toxins, Fourth Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content.
| Author | : W. T. Shier |
| Publisher | : CRC Press |
| Total Pages | : 825 |
| Release | : 2020-08-26 |
| Genre | : Medical |
| ISBN | : 100010446X |
Download Handbook of Toxinology Book in PDF, ePub and Kindle
Organized primarily around the mechanisms of action of the toxins at the biochemical, physiological and pathological level, rather than by source, the handbook covers most toxins which have been clearly identified and characterized, but emphasizes toxins that are more important by virtue of the sign
| Author | : Manfred Schmitt |
| Publisher | : Springer |
| Total Pages | : 237 |
| Release | : 2009-09-02 |
| Genre | : Science |
| ISBN | : 9783540804710 |
Download Microbial Protein Toxins Book in PDF, ePub and Kindle
Since the initial establishment of Robert Koch’s postulates in the nineteenth century, microbial protein toxins have been recognized as a major factor of bacterial and fungal virulence. An increasing number of proteins produced and secreted by various bacteria, yeasts and plants are extremely toxic and most of them developed remarkably "intelligent" strategies to enter, to penetrate and to finally kill a eukaryotic target cell by modifying or blocking essential cellular components. This book describes the strategies employed by protein toxins to render their pro- and eukaryotic producers a selective growth advantage over competitors. In providing an up-to-date overview on the mode of protein toxin actions, it accommodates biomedically and biologically relevant toxin model systems. As a result, it significantly broadens our perspective on biochemical architecture and molecular ploy behind the lethal principles of pro- and eukaryotic toxins.
