Guidance Document On Statistical Methods For Environmental Toxicity Tests PDF Download

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OECD Series on Testing and Assessment Current Approaches in the Statistical Analysis of Ecotoxicity Data A guidance to application (annexes to this publication exist as a separate document)

OECD Series on Testing and Assessment Current Approaches in the Statistical Analysis of Ecotoxicity Data A guidance to application (annexes to this publication exist as a separate document)
Author: OECD
Publisher: OECD Publishing
Total Pages: 147
Release: 2006-05-09
Genre:
ISBN: 9264085270

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This document describes the main statistical methods used for analysis of data from ecotoxicological studies .


Methods for Measuring the Toxicity and Bioaccumulation of Sediment-associated Contaminants with Freshwater Invertebrates

Methods for Measuring the Toxicity and Bioaccumulation of Sediment-associated Contaminants with Freshwater Invertebrates
Author:
Publisher:
Total Pages: 150
Release: 1994
Genre: Freshwater invertebrates
ISBN:

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Sediment contamination is a widespread environmental problem that can potentially pose a threat to a variety of aquatic ecosystems. The sediment test methods in this manual will be used by The United States Environmental Protection Agency (USEPA) to make decisions under a range of statutory authorities concerning such issues as: dredged material disposal, registration of pesticides and toxic substances, superfound site assessment, and assessment and cleanup of hazardous waste treatment, storage, and disposal facilities. The use of uniform sediment testing procedures by USEPA programs is expected to increase data accuracy and precision, facilitate test replication, increase the comparative value of test results, and ultimately, increase the efficiency of regulatory processes requiring sediment tests.


Guidance Document on Control of Toxicity Test Precision Using Reference Toxicants

Guidance Document on Control of Toxicity Test Precision Using Reference Toxicants
Author: Canada. Environmental Protection Service
Publisher: Environment Canada
Total Pages: 104
Release: 1990
Genre: Aquatic biology
ISBN:

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A reference toxicant is a chemical used in toxicity tests to provide results that can be compared within a laboratory or among laboratories. This report describes the use of reference toxicants within a laboratory for control of toxicity test precision over time. Thirteen chemicals were evaluated for their suitability as reference toxicants. Procedures for chemical acquisition, safe handling and storage are presented and instructions are provided for establishing and interpreting control charts, as well as reporting data. Monitoring and interpreting duplicate test data are also discussed.


Guidance Document on Measurement of Toxicity Test Precision Using Control Sediments Spiked with a Reference Toxicant

Guidance Document on Measurement of Toxicity Test Precision Using Control Sediments Spiked with a Reference Toxicant
Author: Roman Lanno
Publisher:
Total Pages: 82
Release: 1995
Genre: Technology & Engineering
ISBN:

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This report provides guidance and recommendations for selection of a reference toxicant, spiking procedures, and use of control sediments for assessing changes in sensitivity of test organisms to toxicants and measuring precision of both intra- and inter-laboratory spiked-sediment toxicity tests. Four potential reference toxicants (cadmium, copper, pentachlorophenate, and fluoranthene) were considered for selection since they were the only chemicals with published information regarding sediment spiking and use in sediment toxicity tests. The recommendations on the use of these toxicants in tests using either freshwater or marine sediment reflect the information currently available. Instructions are included for the selection of control sediments for spiking, selection and use of test organisms, acquisition and handling of chemicals, conducting reference toxicant tests, establishing and updating warning charts, record keeping, and data reporting. Key areas requiring further research are also identified. The appendices include a summary of current research on formulated sediments, a list of information typically provided in a material safety data sheet, and graphs showing the fate of copper and cadmium added to natural seawater.


Toxicity Testing for Assessment of Environmental Agents

Toxicity Testing for Assessment of Environmental Agents
Author: National Research Council
Publisher: National Academies Press
Total Pages: 270
Release: 2006-04-07
Genre: Nature
ISBN: 0309164869

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Toxicity testing in laboratory animals provides much of the information used by the Environmental Protection Agency (EPA) to assess the hazards and risks associated with exposure to environmental agents that might harm public health or the environment. The data are used to establish maximum acceptable concentrations of environmental agents in drinking water, set permissible limits of exposure of workers, define labeling requirements, establish tolerances for pesticides residues on food, and set other kinds of limits on the basis of risk assessment. Because the number of regulations that require toxicity testing is growing, EPA called for a comprehensive review of established and emerging toxicity-testing methods and strategies. This interim report reviews current toxicity-testing methods and strategies and near-term improvements in toxicity-testing approaches proposed by EPA and others. It identifies several recurring themes and questions in the various reports reviewed. The final report will present a long-range vision and strategic plan to advance the practices of toxicity testing and human health assessment of environmental contaminants.