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Guidance Cues in the Developing Brain

Guidance Cues in the Developing Brain
Author: Ivica Kostovic
Publisher: Springer Science & Business Media
Total Pages: 174
Release: 2012-12-06
Genre: Science
ISBN: 3642555578

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Many complex molecular interactions are involved in the development of the mammalian brain. Molecules serving as guidance cues for migratory cells, growing axons and for recognition of postsynaptic targets are a major topic for research because they are directly involved in the formation of neuronal circuits, thus creating the foundation for subsequent functional refinement through interactions with the environment. In addition, most guidance cue molecules are also involved in plasticity, damage repair and regeneration in the adult brain. This volume reviews current knowledge on major classes of molecules involved in: guidance of growing axons; tau proteins involved in the establishment of axonal polarity, outgrowth and contact recognition; gangliosides and lectins involved in neuronal migration, neurite outgrowth and contact recognition; and myelin molecules that inhibit nerve regeneration.


Neuronal Guidance

Neuronal Guidance
Author: Marc Tessier-Lavigne
Publisher:
Total Pages: 0
Release: 2011
Genre: Medical
ISBN: 9780879698973

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During the development of the brain growing nerves send out neuronal processes (axons and dendrites) that connect them to other nerve cells, sensory organs, and muscle tissue. Correct targeting of these is the basis for wiring of the entire nervous system and depends on attractive and repulsive molecular cues that guide the developing neurons to the appropriate destination. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the mechanisms underlying neuronal guidance and branching and their roles in the development and function of the nervous system. The contributors examine the major guidance cues and their receptors, the intracellular signaling pathways they activate, and their function in the context of important phenomena such as laminar organization and dendrite spacing. Other chapters consider the roles of guidance cues in development of neuronal circuits dedicated to the processing of particular sensory stimuli, such as the visual and olfactory systems. In addition, they cover the roles played by guidance cues and their receptors in neuronal regeneration and human genetic disorders, revealing important clinical implications of work in this field. The book also contains chapters discussing the function of guidance molecules in other processes, such as neuronal cell body migration, axon pruning, and regulation of neuronal cell death. In addition, it explores their roles outside the nervous system for example, in development of the vasculature. This volume is thus of general interest to cell and developmental biologists, as well as all neurobiologists interested in how the nervous system develops and functions.


Synaptic Roles for Developmental Cues

Synaptic Roles for Developmental Cues
Author: Katherine Horn
Publisher:
Total Pages:
Release: 2013
Genre:
ISBN:

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"The role of axon guidance cues during development has been extensively investigated. However, the expression of many of these cues, including the canonical axon guidance cue netrin-1 and its receptor Deleted in Colorectal Cancer (DCC), as well as the receptor protein tyrosine phosphatase [sigma] (RPTP[sigma]), remain long after development is complete, and can be detected in the adult mammalian nervous system, suggesting that these proteins may have roles beyond guidance.Here, we begin by investigating the role of the netrin-1 receptor DCC in synaptic regulation. We address the role of DCC in the arborization of neurites, which modulates the amount of synaptic connections that may be formed, and find that DCC plays a key role in netrin-1 induced neurite branching, through mechanisms that may be independent of netrin-1 induced axon outgrowth. In the mature nervous system, DCC is found to be enriched at synapses. Use of a transgenic mouse model engineered to conditionally delete DCC from forebrain neurons after axon guidance is complete shows that DCC regulates dendritic spine size, and is essential for both spatial and recognition memory. Furthermore, electrophysiologically, DCC deficient mice exhibit impaired long term potentiation (LTP), and a decrease in activated Src family kinases, which have previously been shown to have an essential role in regulating the NMDA receptors (NMDARs) to permit LTP. The impairment in LTP can be rescued through the facilitation of NMDARs by slight alterations in the extracellular recording solution, and through pharmacological activation of Src. We thus conclude that DCC regulates the induction of LTP through an established pathway that includes the activation of Src to modulate NMDAR function.RPTP[sigma], another cue previously implicated in axon guidance, was also found to be enriched in synaptic membranes in the mature brain. Using a transgenic mouse null for RPTP[sigma], we find that in the mature brain, RPTP[sigma] restricts aberrant sprouting, regulates spine density in vitro and in vivo, affects the synaptic properties of hippocampal cells, and alters performance in a behavioural test assessing recognition memory. Together, these results suggest the presence of increased synaptic connections in RPTP[sigma] deficient mice. Overall, we show that cues formerly implicated in axon guidance have roles beyond development, with their expression in the adult nervous system leading to synaptic regulation in the mature brain." --


Discovering the Brain

Discovering the Brain
Author: National Academy of Sciences
Publisher: National Academies Press
Total Pages: 195
Release: 1992-01-01
Genre: Medical
ISBN: 0309045290

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The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."


Creating Connections in the Developing Brain

Creating Connections in the Developing Brain
Author: Ilan Gobius
Publisher: Biota Publishing
Total Pages: 50
Release: 2011-07-01
Genre: Medical
ISBN: 161504079X

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The corpus callosum is the largest fibre tract in the human brain and subserves many of the brain’s higher-order functions. Disconnection syndromes resulting from surgical ablation, developmental absence (agenesis of the corpus callosum), disease, or injury of the corpus callosum can have profound consequences on cognition. Callosal development involves an intricate series of sequential and concurrent processes, including telencephalic induction, midline tissue patterning, production and specification of callosal neurons. In addition, axon extension and long-range axonal guidance from one hemisphere to the other are required for functional circuit formation in the contralateral hemisphere. Genetic or traumatic disruption to any part of this sequence is pathogenic. Understanding the key processes involved in callosal development is the first step in providing both better neuropsychological outcomes and improved diagnostic and prognostic tools for congenital disconnection syndromes in the future.


RNA and Protein Networks That Locally Control Brain Wiring During Development

RNA and Protein Networks That Locally Control Brain Wiring During Development
Author: Alexander James Murphy
Publisher:
Total Pages:
Release: 2015
Genre:
ISBN:

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The molecular machineries of growth cones control the formation of neural circuits in the developing brain. Although great progress has been made in elucidating axon guidance cues and their growth cone receptors, we still lack an understanding of the projection-specific RNA and protein networks in growth cones that likely control the wiring of specific circuits in vivo.


Building Brains

Building Brains
Author: David J. Price
Publisher: John Wiley & Sons
Total Pages: 386
Release: 2017-11-29
Genre: Medical
ISBN: 111929388X

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Provides a highly visual, readily accessible introduction to the main events that occur during neural development and their mechanisms Building Brains: An Introduction to Neural Development, 2nd Edition describes how brains construct themselves, from simple beginnings in the early embryo to become the most complex living structures on the planet. It explains how cells first become neural, how their proliferation is controlled, what regulates the types of neural cells they become, how neurons connect to each other, how these connections are later refined under the influence of neural activity, and why some neurons normally die. This student-friendly guide stresses and justifies the generally-held belief that a greater knowledge of how nervous systems construct themselves will help us find new ways of treating diseases of the nervous system that are thought to originate from faulty development, such as autism spectrum disorders, epilepsy, and schizophrenia. A concise, illustrated guide focusing on core elements and emphasizing common principles of developmental mechanisms, supplemented by suggestions for further reading Text boxes provide detail on major advances, issues of particular uncertainty or controversy, and examples of human diseases that result from abnormal development Introduces the methods for studying neural development, allowing the reader to understand the main evidence underlying research advances Offers a balanced mammalian/non-mammalian perspective (and emphasizes mechanisms that are conserved across species), drawing on examples from model organisms like the fruit fly, nematode worm, frog, zebrafish, chick, mouse and human Associated Website includes all the figures from the textbook and explanatory movies Filled with full-colorartwork that reinforces important concepts; an extensive glossary and definitions that help readers from different backgrounds; and chapter summaries that stress important points and aid revision, Building Brains: An Introduction to Neural Development, 2nd Edition is perfect for undergraduate students and postgraduates who may not have a background in neuroscience and/or molecular genetics. “This elegant book ranges with ease and authority over the vast field of developmental neuroscience. This excellent textbook should be on the shelf of every neuroscientist, as well as on the reading list of every neuroscience student.” —Sir Colin Blakemore, Oxford University “With an extensive use of clear and colorful illustrations, this book makes accessible to undergraduates the beauty and complexity of neural development. The book fills a void in undergraduate neuroscience curricula.” —Professor Mark Bear, Picower Institute, MIT. Highly Commended, British Medical Association Medical Book Awards 2012 Published with the New York Academy of Sciences


Cellular Migration and Formation of Neuronal Connections

Cellular Migration and Formation of Neuronal Connections
Author:
Publisher: Academic Press
Total Pages: 1081
Release: 2013-05-06
Genre: Science
ISBN: 0123973473

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The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 2 offers 56 high level articles devoted mainly to Formation of Axons and Dendrites, Migration, Synaptogenesis, Developmental Sequences in the Maturation of Intrinsic and Synapse Driven Patterns. Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop Features leading experts in various subfields as Section Editors and article Authors All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship Volume 2 sections include coverage of mechanisms which regulate: the formation of axons and dendrites, cell migration, synapse formation and maintenance during development, and neural activity, from cell-intrinsic maturation to early correlated patterns of activity


How People Learn II

How People Learn II
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Total Pages: 347
Release: 2018-09-27
Genre: Education
ISBN: 0309459672

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There are many reasons to be curious about the way people learn, and the past several decades have seen an explosion of research that has important implications for individual learning, schooling, workforce training, and policy. In 2000, How People Learn: Brain, Mind, Experience, and School: Expanded Edition was published and its influence has been wide and deep. The report summarized insights on the nature of learning in school-aged children; described principles for the design of effective learning environments; and provided examples of how that could be implemented in the classroom. Since then, researchers have continued to investigate the nature of learning and have generated new findings related to the neurological processes involved in learning, individual and cultural variability related to learning, and educational technologies. In addition to expanding scientific understanding of the mechanisms of learning and how the brain adapts throughout the lifespan, there have been important discoveries about influences on learning, particularly sociocultural factors and the structure of learning environments. How People Learn II: Learners, Contexts, and Cultures provides a much-needed update incorporating insights gained from this research over the past decade. The book expands on the foundation laid out in the 2000 report and takes an in-depth look at the constellation of influences that affect individual learning. How People Learn II will become an indispensable resource to understand learning throughout the lifespan for educators of students and adults.