Glucose Transport Into Skeletal Muscle
Author | : Harriet Wallberg-Henriksson |
Publisher | : |
Total Pages | : 92 |
Release | : 1987 |
Genre | : Biological transport |
ISBN | : |
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Author | : Harriet Wallberg-Henriksson |
Publisher | : |
Total Pages | : 92 |
Release | : 1987 |
Genre | : Biological transport |
ISBN | : |
Author | : Erik A. Richter |
Publisher | : Springer Science & Business Media |
Total Pages | : 325 |
Release | : 2013-11-11 |
Genre | : Science |
ISBN | : 1489919287 |
The Copenhagen Muscle Research Centre was founded in 1994 with the support of a grant from the Danish National Research Foundation. Among the goals for the Centre is the organization of research symposia, with the aim of bringing a limited number ofintemation ally renowned scientists together to discuss the latest developments and perspectives in their field. The first Copenhagen Muscle Research Centre Conference was held in 1995 and dealt with cardiovascular regulation. The Second Copenhagen Muscle Research Centre Confer ence was held from October 23-26, 1997. The topic of the Symposium was Muscle Metabo lism: Regulation, Exercise, and Diabetes. Seventy invited scientists from all over the world discussed their latest research related to skeletal muscle metabolism. The speakers were asked to expand on their presentations and to write short, but comprehensive, chapters about their given topics. The result is 28 peer-reviewed and edited chapters covering many if not all aspects of muscle energy metabolism related to exercise and diabetes. Emphasis is on regulation of glucose and fatty acid metabolism and the mechanisms regulating their use as fuels for the muscle during exercise. In addition, abnormalities in the regulation of glucose metabolism in the diabetic state are described. However, amino acid and protein metabolism are also thoroughly discussed. We believe that this volume brings an unparralleled, up to date, and comprehensive review of the frontiers in muscle metabolism. Erik A.
Author | : Ashok K. Srivastava |
Publisher | : Springer Science & Business Media |
Total Pages | : 206 |
Release | : 1998-05-31 |
Genre | : Science |
ISBN | : 9780792381136 |
In 1996 the 75th anniversary of the discovery of insulin was celebrated at the University of Toronto, the scene of that discovery in 1921. This volume was stimulated by the scientific program which was staged at that time and brought together much of the world's best talent to discuss and analyze the most recent developments in our understanding of pancreatic function, insulin secretion, the interaction of insulin with its target tissues, the mechanism of insulin action at the cellular level, and the defects which underlie both Type I (insulin-dependent diabetes mellitus, IDDM) and Type II (noninsulin-dependent diabetes mellitus, NIDDM) forms of the disease. We have chosen to focus the present volume on work related to insulin action.
Author | : Juleen R. Zierath |
Publisher | : |
Total Pages | : 100 |
Release | : 1995 |
Genre | : Biological transport |
ISBN | : |
Author | : Zayna A. Khayat |
Publisher | : |
Total Pages | : |
Release | : 2001 |
Genre | : |
ISBN | : |
Glucose is a universal energy substrate of mammalian cells. The Thesis examines the two main pathways of regulating glucose transport in muscle cells--insulin and the metabolic demand pathway. Insulin and the mitochondrial uncoupler dinitrophenol (DNP) were used to stimulate these two pathways in L6 muscle cells in order to dissect differences involving 3 major cellular regulatory pathways: (1) the actin cytoskeleton and temporal spatial regulation of signals and glucose transporters; (2) signalling pathways activated by these stimuli; and (3) cellular mechanisms controlling chronic glucose transporter expression. The results demonstrate that insulin provokes a rapid and marked aggregation of filamentous actin into structures that provide the coordinates for the insulin-derived signals to meet glucose transporter organelles, and direct their insertion into membrane ruffles. The results also reveal that, in contrast to insulin, DNP-stimulated glucose uptake largely depends on cytosolic Ca2+ and Ca2+-sensitive PKCs, but likely does not engage the fuel sensing enzyme AMPK. Finally, insulin and DNP were shown to elicit different long-term effects on glucose transporter expression: whereas prolonged exposure to insulin increases glucose transporter biosynthesis, chronic exposure to DNP increases the half-life of the glucose transporters in an isoform-specific manner. By uncovering the different cellular factors accessed by insulin and DNP to control glucose transport, the Thesis enhances our understanding of the diverse means employed by the muscle cell to control glucose homeostasis, and may have implications for the therapeutic treatment of diseases associated with impaired glucose utilization, such as Type 2 diabetes.
Author | : Gwyn W. Gould |
Publisher | : Springer Science & Business Media |
Total Pages | : 270 |
Release | : 1997-03-15 |
Genre | : Science |
ISBN | : 9780412132919 |
This book is a comprehensive text covering the major aspects of the cell and molecular biology of the facilitative glucose transporter family. The text reviews the biology and function of each family member, covers structure-function studies, the regulation of glucose transport by insulin and the consequence of diabetes and insulin resistance, discusses aspects of cellular signalling which control glucose transport, reviews the control of expression and function of GLUT2 in liver and pancreatic beta-cells, and reviews the effects of nutrients on the control of sugar transporter expression.
Author | : |
Publisher | : |
Total Pages | : 790 |
Release | : 1925 |
Genre | : Biochemistry |
ISBN | : |
Author | : Juleen R Zierath |
Publisher | : CRC Press |
Total Pages | : 659 |
Release | : 2002-02-28 |
Genre | : Medical |
ISBN | : 1134485417 |
Diabetes research on models comprising intact animal tissues, cell cultures and isolated pancreatic islets is essential for understanding the pathogenesis of the disease as well as the mechanisms responsible for the chronic complications associated with it. Enormous advances in the understanding of the development of diabetes and its prevention hav
Author | : Bruce Spiegelman |
Publisher | : Springer |
Total Pages | : 108 |
Release | : 2018-03-07 |
Genre | : Science |
ISBN | : 3319727907 |
The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.
Author | : Charles L. Dumke |
Publisher | : |
Total Pages | : 266 |
Release | : 2000 |
Genre | : |
ISBN | : |