Getting A Handle On Smart Drug Delivery Systems A Comprehensive View Of Therapeutic Targeting Strategies PDF Download
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| Author | : Sugapriya Dhanasekaran |
| Publisher | : |
| Total Pages | : |
| Release | : 2016 |
| Genre | : Medicine |
| ISBN | : |
Download Getting a Handle on Smart Drug Delivery Systems - A Comprehensive View of Therapeutic Targeting Strategies Book in PDF, ePub and Kindle
Smart drug delivery system (SDDS) is a recently emerging therapeutic approach, now turning into a conventional model to deliver drug to specific sites or target. Drug targeted (DT) delivery systems maintain the concentration of the drugs at desirable doses in the body and avoid the need for repeated doses. The DT delivery system have specific distinguishing features such as self-regulated, pre-programmed, multi-targeted, controlled by timely response, monitoring of the targeted drug delivery, responsive to pH, and spatially targeted. The DT delivery system exploits the biological membrane changes in the physiology of malignant cells to increase absorption or entry of drug-coated nanoparticles into targeted tissues. This system delivers a certain quantity of a therapeutic drug for longevity of its action to a targeted area within the human tissue, which in turn enhances efficacy of the treatment by reducing the side effects of drug administration. A new DT therapy strategy is a health improvement technique used in future generations for treatment of genetic diseases and intelligent drug delivery. The ultimate goal of SDDS is to administrate the drugs at the correct time with an exact dose in the body and with efficiency and specificity to the targeted cells that help the patients better adhere to their therapy regimen. The DT system enhances the maintenance of drug levels in targeted tissues and plasma without any destruction to the healthy tissues. This DT delivery system uses various strategies in targeting cells, drug delivery mechanisms, properties of targeted drug, organ-based targeted sites, disease, and drug-targeted vehicles. This chapter deals with all aspects of drug targeting and provides an overview of approaches in drug targeting, drug delivery vehicles, and strategies involved in successful delivery.
| Author | : Padma V. Devarajan |
| Publisher | : Springer |
| Total Pages | : 788 |
| Release | : 2014-12-08 |
| Genre | : Medical |
| ISBN | : 3319113550 |
Download Targeted Drug Delivery : Concepts and Design Book in PDF, ePub and Kindle
This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.
| Author | : Ali Demir Sezer |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 400 |
| Release | : 2016-02-10 |
| Genre | : Medical |
| ISBN | : 9535122479 |
Download Smart Drug Delivery System Book in PDF, ePub and Kindle
This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different smart drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, diabetic, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.
| Author | : Ashim Mitra |
| Publisher | : John Wiley & Sons |
| Total Pages | : 844 |
| Release | : 2013-08-26 |
| Genre | : Medical |
| ISBN | : 1118662849 |
Download Advanced Drug Delivery Book in PDF, ePub and Kindle
Provides both fundamentals and new and emerging applications Advanced Drug Delivery brings readers fully up to date with the state of the science, presenting the basics, formulation strategies, and therapeutic applications of advanced drug delivery. The book demonstrates how core concepts of pharmaceutical sciences, chemistry, and molecular biology can be combined and applied in order to spark novel ideas to design and develop advanced drug delivery systems for the treatment of a broad range of human diseases. Advanced Drug Delivery features contributions from an international team of pharmaceutical scientists. Chapters reflect a thorough review and analysis of the literature as well as the authors' firsthand experience developing drug delivery systems. The book is divided into four parts: Part I, Introduction and Basics of Advanced Drug Delivery, explores physiological barriers, stability, transporters, and biomaterials in drug delivery Part II, Strategies for Advanced Drug Delivery, offers tested and proven strategies for advanced delivery of both small molecules and macromolecules Part III, Translational Research of Advanced Drug Delivery, focuses on regulatory considerations and translational applications of advanced drug delivery systems for the treatment of cardiovascular diseases, cancer, sexually transmitted diseases, ophthalmic diseases, and brain diseases Part IV, Future Applications of Advanced Drug Delivery in Emerging Research Areas, examines stem cell research, cell-based therapeutics, tissue engineering, and molecular imaging Each chapter provides objectives and assessment questions to help readers grasp key concepts and assess their knowledge as they progress through the book. Advanced Drug Delivery is recommended for graduates and upper-level undergraduates in the pharmaceutical sciences who need a solid foundation in the basics. It is also recommended for pharmaceutical professionals who want to take advantage of new and emerging applications in advanced drug delivery systems.
| Author | : |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 170 |
| Release | : 2024-08-21 |
| Genre | : Medical |
| ISBN | : 1837692017 |
Download Smart Drug Delivery Systems Book in PDF, ePub and Kindle
Chemotherapeutic strategies are fundamental for treating diseases like cancer, which metastasizes rapidly to healthy tissues. However, these drugs, being nonspecific, may harm both the diseased as well as the healthy tissues. Rapid clearance, low uptake, and uneven distribution of the payloads at target sites result in poor biodistribution. To address the emerging challenges of off-target accumulation and patient noncompliance, it is crucial to selectively deliver therapeutic agents to target sites, release the loaded cargo efficiently, and remove the chemotherapeutic agents from the system without triggering an immune response. The advent of smart targeting methods has revolutionized drug delivery systems (DDS). Stimuli-responsive smart DDS can release drugs in response to pH, light, redox, magnetic fields, and hyperthermia, marking the future of translational medicine. Exosomes and phytosomes are innovative drug delivery platforms that have brought about a paradigm shift in DDS. Theranostic agents, which combine diagnostic and therapeutic functions, represent a significant advancement in personalized medicine. These agents allow real-time assessment of drug biodistribution, release, and therapeutic outcomes. Theranostic probes, particularly nanoparticles with drug carrier and imaging capabilities, have transformed cancer therapy by enabling precise imaging at tumor sites. This book explores drug delivery strategies for therapeutic products including vitamins, emphasizing the delivery of live cell therapies. It also highlights nanostructured systems tailored for smart drug delivery and theranostic medicines, showcasing promising advancements in this emerging field.
| Author | : Xiaoling Li |
| Publisher | : McGraw Hill Professional |
| Total Pages | : 453 |
| Release | : 2005-11-24 |
| Genre | : Technology & Engineering |
| ISBN | : 0071588833 |
Download Design of Controlled Release Drug Delivery Systems Book in PDF, ePub and Kindle
The goal of every drug delivery system is to deliver the precise amount of a drug at a pre-programmed rate to the desired location in order to achieve the drug level necessary for the treatment. An essential guide for biomedical engineers and pharmaceutical designers, this resource combines physicochemical principles with physiological processes to facilitate the design of systems that will deliver medication at the time and place it is most needed.
| Author | : Pankaj Sharma |
| Publisher | : CRC Press |
| Total Pages | : 271 |
| Release | : 2024-03-21 |
| Genre | : Medical |
| ISBN | : 1003858074 |
Download Smart Nanocarrier for Effective Drug Delivery Book in PDF, ePub and Kindle
Introducing Smart Nanocarrier for Effective Drug Delivery—a pioneering guide that delves into the realm of nanotechnology and its revolutionary impact on drug delivery systems. This comprehensive volume offers a deep understanding of smart nanocarriers' principles, design, and applications, setting it apart as a cutting-edge resource in the field. Nanotechnology has transformed drug delivery, enhanced therapeutic outcomes, and minimized side effects. This book provides a concise yet thorough overview of this dynamic landscape, elucidating key concepts and methodologies. It covers foundational principles and explores advanced strategies for targeted drug delivery, personalized medicine, and combination therapy. KEY FEATURES In-depth exploration of various types of nanocarriers, from liposomes to polymeric nanoparticles, highlighting their unique attributes. Detailed examination of smart stimuli-responsive nanocarriers that release drugs at precise locations and times. Comprehensive analysis of the latest advancements in nanomedicine, including nanodiagnostics and theranostics. Case studies illustrating real-world applications and success stories of nanocarrier-enhanced drug delivery. Smart Nanocarrier for Effective Drug Delivery is an invaluable resource for researchers, practitioners, and students in pharmaceutical sciences, nanotechnology, and drug delivery. It offers a roadmap to harnessing the potential of nanocarriers for enhancing therapeutic efficacy while minimizing adverse effects. This book equips readers with the knowledge to navigate the rapidly evolving landscape of smart nanocarrier technology, making it an essential addition to their professional toolkit.
| Author | : Pieter Stroeve |
| Publisher | : World Scientific |
| Total Pages | : 391 |
| Release | : 2017-11-27 |
| Genre | : Technology & Engineering |
| ISBN | : 9813201061 |
Download Drug Delivery Systems Book in PDF, ePub and Kindle
With the alarming increase in cancer diagnoses and genetic illnesses, traditional drug agents and their delivery media need to be re-evaluated to address a quickly evolving field. With newer smart materials for the controlled release of macromolecules, peptides, genetic material, etc. further complications arise, such as material performance, synthesis, functionalization and targeting, biological identity, and biocompatibility.The book provides a comprehensive overview of the recent developments on 'smart' targeting and drug delivery systems with a variety of carriers like nanoparticles, membranes, and hydrogels. It contains detailed descriptions on the recent trends in this field in the ongoing battle with catastrophic diseases like cancer. This field of research has been in its infancy and continues to face growth, and with it, further challenges and difficulties along the way toward maturity, which are accurately introduced in this book.
| Author | : Kamal Dua |
| Publisher | : Elsevier |
| Total Pages | : 572 |
| Release | : 2021-06-24 |
| Genre | : Business & Economics |
| ISBN | : 0323900798 |
Download Advanced Drug Delivery Systems in the Management of Cancer Book in PDF, ePub and Kindle
Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems
| Author | : Yashwant V. Pathak |
| Publisher | : John Wiley & Sons |
| Total Pages | : 542 |
| Release | : 2012-04-17 |
| Genre | : Science |
| ISBN | : 1118228898 |
Download Antibody-Mediated Drug Delivery Systems Book in PDF, ePub and Kindle
This book covers various aspects of antibody mediated drug delivery systems – theoretical aspects, processing, viral and non-viral vectors, and fields where these systems find and /or are being evaluated for applications as therapeutics and diagnostic treatment. Chapters discuss actual applications of techniques used for formulation and characterization. Applications areas include cancer, pulmonary, ocular diseases; brain drug delivery; and vaccine delivery. The contributing authors represent over 10 different countries, covering recent developments happening around the globe.
