Genomics In Regulatory Ecotoxicology PDF Download
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Author | : Gerald Ankley |
Publisher | : CRC Press |
Total Pages | : 198 |
Release | : 2007-11-27 |
Genre | : Science |
ISBN | : 1420066838 |
Download Genomics in Regulatory Ecotoxicology Book in PDF, ePub and Kindle
Fueled partially by large, well-publicized efforts such as the Human Genome Project, genomic research is a rapidly growing area in multiple biological disciplines, including toxicology. Much of this potential, however, has been discussed in the literature and at technical meetings only in relatively broad terms, making it difficult to assess exactl
Author | : Gerald T. Ankley |
Publisher | : |
Total Pages | : 196 |
Release | : 2007-12 |
Genre | : |
ISBN | : 9781880611388 |
Download Genomics in Regulatory Toxicology Book in PDF, ePub and Kindle
Author | : Richard R. Sharp |
Publisher | : JHU Press |
Total Pages | : 391 |
Release | : 2008-10-14 |
Genre | : Law |
ISBN | : 0801890225 |
Download Genomics and Environmental Regulation Book in PDF, ePub and Kindle
To reduce the deleterious effects of environmental contamination, governments across the world have enacted regulations broadly conceived for entire populations. Information arising out of the Human Genome Project and other cutting-edge genetic research is shifting the policymaking process. This fascinating volume draws on experts from academia, government, industry, and nongovernmental organizations to examine the science of genomic research as applied to environmental policy. The first section explores environmental policy applications, including subpopulation genetic profiling, industrial regulations, and standardizing governmental evaluation of genomic data. The second section assesses from multiple angles the legal framework involved in applying genomics to environmental regulation. In the third section, the contributors review closely the implications of genomic research for occupational health, from disease prevention and genetic susceptibility to toxicants, to workers' rights and potential employment discrimination. A fourth section explores the bioethical and philosophical complications of bringing genetic data and research into nonclinical regulatory frameworks. Genomics and Environmental Regulation points to ways in which information on toxicology and genetics can be used to craft more precise and efficient regulations. -- Wendy Wagner, University of Texas
Author | : William H. Benson |
Publisher | : CRC Press |
Total Pages | : 218 |
Release | : 2006-12-13 |
Genre | : Mathematics |
ISBN | : 1420043641 |
Download Genomic Approaches for Cross-Species Extrapolation in Toxicology Book in PDF, ePub and Kindle
The latest tools for investigating stress response in organisms, genomic technologies provide great insight into how different organisms respond to environmental conditions. However, their usefulness needs to be tested, verified, and codified. Genomic Approaches for Cross-Species Extrapolation in Toxicology provides a balanced discussion drawn from
Author | : C. Cristofre Martin |
Publisher | : Springer Science & Business Media |
Total Pages | : 363 |
Release | : 2008-01-18 |
Genre | : Science |
ISBN | : 1588297772 |
Download Environmental Genomics Book in PDF, ePub and Kindle
Here is a manual for an environmental scientist who wishes to embrace genomics to answer environmental questions. The volume covers: gene expression profiling, whole genome and chromosome mutation detection, and methods to assay genome diversity and polymorphisms within a particular environment. This book provides a systematic framework for determining environmental impact and ensuring human health and the sustainability of natural populations.
Author | : United States Environmental Protection Agency (EPA) |
Publisher | : Createspace Independent Publishing Platform |
Total Pages | : 70 |
Release | : 2018-07-04 |
Genre | : |
ISBN | : 9781722252076 |
Download Potential Implications of Genomics for Regulatory and Risk Assessment Applications at EPA Book in PDF, ePub and Kindle
Potential Implications Of Genomics For Regulatory And Risk Assessment Applications At EPA
Author | : Valery E. Forbes |
Publisher | : CRC Press |
Total Pages | : 244 |
Release | : 2022-01-27 |
Genre | : Science |
ISBN | : 1000124606 |
Download Genetics And Ecotoxicology Book in PDF, ePub and Kindle
This first volume in the series provides a detailed treatment in ecotoxicology and stresses why genetics is important in understanding if and how chemical contaminants affect populations. Written by an array of international contributors from various fields covering mammals, invertebrates, fish, plants, as well as molecular ecotoxicology, this book considers both ecological/evolutionary consequences and practical implications of the interplay between chemical toxicants and the genetic population. In broadening the understanding of ecological response, this resource ranges from molecular to classical genetics, from plant to animal, from asexual to sexual, touching on some fundamental issues of evolutionary biology. In addition, gaps in our present understanding of genetic and ecotoxicological processes and future research directions have been identified.
Author | : Qiang Zhang |
Publisher | : Frontiers Media SA |
Total Pages | : 111 |
Release | : 2021-07-14 |
Genre | : Science |
ISBN | : 2889710440 |
Download Environmental Genomics and Epigenomics: Response, Development and Disease Book in PDF, ePub and Kindle
Author | : Danyel Jennen |
Publisher | : Frontiers Media SA |
Total Pages | : 148 |
Release | : 2020-02-27 |
Genre | : |
ISBN | : 288963521X |
Download Emerging Bioinformatic Tools in Toxicogenomics Book in PDF, ePub and Kindle
Toxicogenomics was established as a merger of toxicology with genomics approaches and methodologies more than 15 years ago, and considered of major value for studying toxic mechanisms-of-action in greater depth and for classification of toxic agents for predicting adverse human health risks. While the original focus was on technological validation of in particular microarray-based whole genome expression analysis (transcriptomics), mainly through cross-comparing different platforms for data generation (MAQC-I), it was soon appreciated that actually the wide variety of data analysis approaches represents the major source of inter-study variation. This led to early attempts towards harmonizing data analysis protocols focusing on microarray-based models for predicting toxicological and clinical end-points and on different methods for GWAS data (MAQC-II). Simultaneously, further technological developments, geared by increasing insights into the complexity of cellular regulation, enabled analyzing molecular perturbations across multiple genomics scales (epigenomics and microRNAs, metabolomics). While these were initially still based on microarray technology, this is currently being phased out and replaced by a variety of next generation sequencing-based methods enabling exploration of genomic responses to toxicants at even greater depth (SEQC-I). This raises the demand for reliable and robust data analysis approaches, ranging from harmonized bioinformatics concepts for preprocessing raw data to non-supervised and supervised methods for capturing and integrating the dynamic perturbations of cell function across dose and time, and thus retrieving mechanistic insights across multiple regulation scales. Traditional toxicology focused on dose-dependently determining apical endpoints of toxicity. With the advent of toxicogenomics, efforts towards better understanding underlying molecular mechanisms has led to the development of the concept of Adverse Outcome Pathways, which are basically presented as a structural network of linearly related gene-gene interactions regulating key events for inducing apical toxic endpoints of interest. Impulse challenges from exposure of biological systems to toxic agents will however induce a cascade-type of events, presenting both adverse and adaptive processes, thus requiring bioinformatics approaches and methods for complex dynamic data, generated not only across dose, but clearly also across time. Currently, time-resolved toxicogenomics data sets are increasingly being assembled in the course of large-scaled research projects, for instance devoted towards developing toxicogenomics-based predictive assays for evaluating chemical safety which are no longer animal-based.
Author | : Peter G. C. Campbell |
Publisher | : Cambridge University Press |
Total Pages | : 598 |
Release | : 2022-05-19 |
Genre | : Science |
ISBN | : 1108890784 |
Download Ecotoxicology Book in PDF, ePub and Kindle
Ecotoxicology offers a comprehensive overview of the science underpinning the recognition and management of environmental contamination. It describes the toxicology of environmental contaminants, the methods used for assessing their toxicity and ecological impacts, and approaches employed to mitigate pollution and ecological health risks globally. Chapters cover the latest advances in research, including genomics, natural toxins, endocrine disruption and the toxicology of radioactive substances. The second half of the book focuses on applications, such as cradle-to-grave effects of selected industries, legal and economic approaches to environmental regulation, ecological risk assessment, and contaminated site remediation. With short capsules written by invited experts, numerous case studies from around the world and further reading lists, this textbook is designed for advanced undergraduate and graduate one-semester courses. It is also a valuable reference for graduate students and professionals. Online resources for instructors and students are also available.