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Genomic Perl

Genomic Perl
Author: Rex A. Dwyer
Publisher: Cambridge University Press
Total Pages: 360
Release: 2003
Genre: Computers
ISBN: 9780521801775

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This introduction to computational molecular biology will help programmers and biologists learn the skills needed to start work in this important, expanding field. The author explains many of the basic computational problems and gives concise, working programs to solve them in the Perl programming language. With minimal prerequisites, the author explains the biological background for each problem, develops a model for the solution, then introduces the Perl concepts needed to implement the solution. The book covers pairwise and multiple sequence alignment, fast database searches for homologous sequences, protein motif identification, genome rearrangement, physical mapping, phylogeny reconstruction, satellite identification, sequence assembly, gene finding, and RNA secondary structure. The concrete examples and step-by-step approach make it easy to grasp the computational and statistical methods, including dynamic programming, branch-and-bound optimization, greedy methods, maximum likelihood methods, substitution matrices, BLAST searching, and Karlin-Altschul statistics. Perl code is provided on the accompanying CD.


Genomes, Browsers and Databases

Genomes, Browsers and Databases
Author: Peter Schattner
Publisher: Cambridge University Press
Total Pages: 329
Release: 2008-06-16
Genre: Science
ISBN: 1139472712

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The recent explosive growth of biological data has lead to a rapid increase in the number of molecular biology databases. Held in many different locations and often using varying interfaces and non-standard data formats, integrating and comparing data from these multiple databases can be difficult and time-consuming. This book provides an overview of the key tools currently available for large-scale comparisons of gene sequences and annotations, focusing on the databases and tools from the University of California, Santa Cruz (UCSC), Ensembl, and the National Centre for Biotechnology Information (NCBI). Written specifically for biology and bioinformatics students and researchers, it aims to give an appreciation of the methods by which the browsers and their databases are constructed, enabling readers to determine which tool is the most appropriate for their requirements. Each chapter contains a summary and exercises to aid understanding and promote effective use of these important tools.


Genome and Genomics

Genome and Genomics
Author: K. V. Chaitanya
Publisher: Springer Nature
Total Pages: 319
Release: 2019-11-17
Genre: Medical
ISBN: 9811507023

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This book provides a detailed and up-to-dated information on the genomes belonging to three major life forms on Earth – archaea, prokaryotes and eukaryotes. Each section describes about the genome of a specific group of organisms, such as viruses, archaea, bacteria, eukaryotes and organellar genomes. Individual chapters provide details of their organization, structure, evolution, sequencing strategies and functions. Further, this book discusses the technologies that are applied for genome sequencing; assembly, annotation and gene prediction. Other topics include the genomes of important model organisms, mitochondria genome of Neanderthal fossil, etc. This book also examines the evolution of chloroplast and mitochondria genomes by comparing with bacteria, addresses the diseases that occur in humans due to the mutations in mitochondrial genome, gene therapy and engineering of chloroplast and mitochondrial genomes. Lastly, it features an overview of the role of proteomics, exposomics, connectomics, metabolomics, and microbiomics. This book is a fascinating read for students, lecturers and researchers in the field of genetics, genomics, microbiology and life sciences.


UNIX and Perl to the Rescue!

UNIX and Perl to the Rescue!
Author: Keith Bradnam
Publisher: Cambridge University Press
Total Pages: 429
Release: 2012-07-19
Genre: Science
ISBN: 1107377773

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Your research has generated gigabytes of data and now you need to analyse it. You hate using spreadsheets but it is all you know, so what else can you do? This book will transform how you work with large and complex data sets, teaching you powerful programming tools for slicing and dicing data to suit your needs. Written in a fun and accessible style, this step-by-step guide will inspire and inform non-programmers about the essential aspects of Unix and Perl. It shows how, with just a little programming knowledge, you can write programs that could save you hours, or even days. No prior experience is required and new concepts are introduced using numerous code examples that you can try out for yourself. Going beyond the basics, the authors touch upon many broader topics that will help those new to programming, including debugging and how to write in a good programming style.


Genome Mapping

Genome Mapping
Author: Jon Schiller
Publisher: CreateSpace
Total Pages: 208
Release: 2010-08-07
Genre: Science
ISBN: 1453735437

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Your author decided to write this book about Genome Mapping after attending a Dinner Lecture for Caltech Alumni living in the Santa Barbara County area of Mid-Coast California Dr David Barker, BS 1963 Caltech & PhD in Biochemistry from Brandeis University, gave a slide presentation on DNA sequencing and what it can tell you. In my quest for more knowledge about this exciting area of biochemistry, I sought more information about Genome Mapping and Entire DNA Sequencing from the Google and Yahoo search engines. As is common in Internet Research, I found a great deal of research was taking place worldwide. It was my objective to summarize this research in this book so my readers could learn what is happening and where to find more information about this important area of Biochemistry. One possibility is modifying your DNA to reduce susceptibility to certain diseases..perhaps we will be able to reduce our risk of cancer. One of my good friends died recently of Prostate Cancer, so my interest in combating Cancer has been intensified.


Aquaculture Genome Technologies

Aquaculture Genome Technologies
Author: Zhanjiang (John) Liu
Publisher: John Wiley & Sons
Total Pages: 579
Release: 2008-02-28
Genre: Technology & Engineering
ISBN: 0470276339

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Genomics is a rapidly growing scientific field with applications ranging from improved disease resistance to increased rate of growth. Aquaculture Genome Technologies comprehensively covers the field of genomics and its applications to the aquaculture industry. This volume looks to bridge the gap between a basic understanding of genomic technology to its practical use in the aquaculture industry.


Genome Plasticity in Health and Disease

Genome Plasticity in Health and Disease
Author:
Publisher: Academic Press
Total Pages: 290
Release: 2020-04-08
Genre: Medical
ISBN: 0128178205

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Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors, non-coding RNAs, telomere dynamics and RNA editing. Later chapters explore disease relevance for cancer, as well as cardiovascular, neuropsychiatric, inflammatory, and endocrine disease, and associated pathways for drug discovery. Examines the role of genome plasticity across a range of disease types, from cardiovascular disease, to cancer and neuropsychiatric disorders Adopts an interdisciplinary approach, with expert contributions across the spectrum of basic science and disease relevance to drug discovery


The Flax Genome

The Flax Genome
Author: Frank M. You
Publisher: Springer Nature
Total Pages: 301
Release: 2023-03-01
Genre: Science
ISBN: 3031160614

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The Flax Genome is a comprehensive compilation of most recent studies focused on reference genome, genetic resources and molecular diversity, breeding, QTL mapping, gene editing tools, functional genomics and metabolomics, molecular breeding via genomic selection, and genomic resources. The flax genome reference sequences and the new genome assemblies are presented. A list of flax QTL and candidate genes associated with more than 35 traits, including yield and agronomic, seed quality and fatty acid composition, fibre quality and yield, abiotic stress, and disease resistance traits, are summarized. A QTL- based genomic selection strategy and genome–editing tools are systematically introduced. In addition, huge amounts of flax genomic resources generated in the last decade are summarized. The book contains 13 chapters with about 390 pages authored by globally reputed researchers in the relevant fields to this crop The book is intended to be useful to students, teachers, and researchers interested in traditional and molecular breeding, pathology, molecular genetics and breeding, bioinformatics and computational biology, and functional genomics


The Capsicum Genome

The Capsicum Genome
Author: Nirala Ramchiary
Publisher: Springer
Total Pages: 232
Release: 2019-02-18
Genre: Science
ISBN: 3319972170

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This book contains complete information on Capsicum genetic resources, diversity, evolution, history and advances in capsicum improvement from classical breeding to whole genome sequencing, genomics, databases and its impact on next generation pepper breeding. Capsicum is one of the most important Solanaceae crops grown worldwide as vegetables and spices. Due to its high economic value and to meet the demands of enormous population growth amid biotic and abiotic stresses, there has been an ongoing breeding program utilizing available genetic resources with desired traits to increase the sustainable productivity of this crop for several decades. However, the precision breeding of this crop for desired traits only started with the advent of molecular markers. The recent advances in high-throughput genome sequencing technologies helped in the quick decoding of transcriptome, epigenome, nuclear and organeller genomes, thereby enhancing our understanding of the structure and function of the Capsicum genome, and helping in genomics assisted breeding. These advanced technologies coupled with conventional mapping have greatly contributed towards dissection and manipulation of economically important traits more precisely and made less time consuming.