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Mapping and Sequencing the Human Genome

Mapping and Sequencing the Human Genome
Author: National Research Council
Publisher: National Academies Press
Total Pages: 128
Release: 1988-01-01
Genre: Science
ISBN: 0309038405

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There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.


The Handbook of Plant Genome Mapping

The Handbook of Plant Genome Mapping
Author: Khalid Meksem
Publisher: John Wiley & Sons
Total Pages: 402
Release: 2006-03-06
Genre: Science
ISBN: 352760443X

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While the complete sequencing of the genomes of model organisms such as a multitude of bacteria and archaea, the yeast Saccharomyces cerevisiae, the worm Caenorhabditis elegans, the fly Drosophila melanogaster, and the mouse and human genomes have received much public attention, the deciphering of plant genomeswas greatly lagging behind. Up to now, only two plant genomes, one of the model plant Arabidopsis thaliana and one of the crop species rice (Oryza sativa) have been sequenced, though a series of other crop genome sequencing projects are underway. Notwithstanding this public bias towards genomics of animals and humans, it is nevertheless of great importance for basic and applied sciences and industries in such diverse fields as agriculture, breeding in particular, evolutionary genetics, biotechnology, and food science to know the composition of crop plant genomes in detail. It is equally crucial for a deeper understanding of the molecular basis of biodiversity and synteny. The Handbook of Genome Mapping: Genetic and Physical Mapping is the first book on the market to cover these hot topics in considerable detail, and is set apart by its combination of genetic and physical mapping. Throughout, each chapter begins with an easy-to-read introduction, also making the book the first reference designed for non-specialists and newcomers, too. In addition to being an outstanding bench work reference, the book is an excellent textbook for learning and teaching genomics, in particular for courses on genome mapping. It also serves as an up-to-date guide for seasoned researchers involved in the genetic and physical mapping of genomes, especially plant genomes.


Mapping the Travel Behavior Genome

Mapping the Travel Behavior Genome
Author: Konstadinos G. Goulias
Publisher:
Total Pages: 734
Release: 2019-10-26
Genre:
ISBN: 0128173408

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Mapping the Travel Behavior Genome covers the latest research on the biological, motivational, cognitive, situational, and dispositional factors that drive activity-travel behavior. Organized into three sections, Retrospective and Prospective Survey of Travel Behavior Research, New Research Methods and Findings, and Future Research, the chapters of this book provide evidence of progress made in the most recent years in four dimensions of the travel behavior genome. These dimensions are Substantive Problems, Theoretical and Conceptual Frameworks, Behavioral Measurement, and Behavioral Analysis. Including the movement of goods as well as the movement of people, the book shows how traveler values, norms, attitudes, perceptions, emotions, feelings, and constraints lead to observed behavior; how to design efficient infrastructure and services to meet tomorrow's needs for accessibility and mobility; how to assess equity and distributional justice; and how to assess and implement policies for improving sustainability and quality of life. Mapping the Travel Behavior Genome examines the paradigm shift toward more dynamic, user-centric, demand-responsive transport services, including the "sharing economy," mobility as a service, automation, and robotics. This volume provides research directions to answer behavioral questions emerging from these upheavals. Offers a wide variety of approaches from leading travel behavior researchers from around the world Provides a complete map of the methods, skills, and knowledge needed to work in travel behavior Describes the state of the art in travel behavior research, providing key directions for future research


Gene-Mapping Techniques and Applications

Gene-Mapping Techniques and Applications
Author: Lawrence B. Schook
Publisher: CRC Press
Total Pages: 353
Release: 2020-07-24
Genre: Science
ISBN: 100010463X

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This book explains current strategies for mapping genomes of higher organisms and explores applications of gene mapping to agriculturally important species of plants and animals. It also explores the experimental techniques used for genetic and physical mapping of genes.


Gene Mapping

Gene Mapping
Author: George J. Annas
Publisher: Oxford University Press, USA
Total Pages: 330
Release: 1992
Genre: Medical
ISBN:

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This timely work brings together a group of the nation's leading experts in genetics, medicine, history of science, health, law, philosophy of science, and medical ethics to assess the current state of modern human genetics, and to begin to chart the legal and ethical guidelines needed to prevent the misuse of human genetics from leading to the abuse of human beings. The six sections of the book, read together, map the social policy con tours of modern human genetics. The first part describes the science of the Human Genome Project. The second addresses specific social policy implications, including the relevance of recombinant DNA history, the eugenics legacy, military applications, and issues of race and class in the context of genetic discrimination. Broader philosophical issues, including reductionism and determinism, the concept of disease, and using germline gene therapy to "improve" human beings are discussed in the third part.


Statistical Genetics

Statistical Genetics
Author: Benjamin Neale
Publisher: Garland Science
Total Pages: 608
Release: 2007-11-30
Genre: Science
ISBN: 1134129335

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Statistical Genetics is an advanced textbook focusing on conducting genome-wide linkage and association analysis in order to identify the genes responsible for complex behaviors and diseases. Starting with an introductory section on statistics and quantitative genetics, it covers both established and new methodologies, providing the genetic and statistical theory on which they are based. Each chapter is written by leading researchers, who give the reader the benefit of their experience with worked examples, study design, and sources of error. The text can be used in conjunction with an associated website (www.genemapping.org) that provides supplementary material and links to downloadable software.


Genome Mapping and Genomics in Human and Non-Human Primates

Genome Mapping and Genomics in Human and Non-Human Primates
Author: Ravindranath Duggirala
Publisher: Springer
Total Pages: 305
Release: 2015-03-25
Genre: Science
ISBN: 3662463067

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This book provides an introduction to the latest gene mapping techniques and their applications in biomedical research and evolutionary biology. It especially highlights the advances made in large-scale genomic sequencing. Results of studies that illustrate how the new approaches have improved our understanding of the genetic basis of complex phenotypes including multifactorial diseases (e.g., cardiovascular disease, type 2 diabetes, and obesity), anatomic characteristics (e.g., the craniofacial complex), and neurological and behavioral phenotypes (e.g., human brain structure and nonhuman primate behavior) are presented. Topics covered include linkage and association methods, gene expression, copy number variation, next-generation sequencing, comparative genomics, population structure, and a discussion of the Human Genome Project. Further included are discussions of the use of statistical genetic and genetic epidemiologic techniques to decipher the genetic architecture of normal and disease-related complex phenotypes using data from both humans and non-human primates.


Gene-Mapping Techniques and Applications

Gene-Mapping Techniques and Applications
Author: Lawrence B. Schook
Publisher: CRC Press
Total Pages: 360
Release: 2020-07-24
Genre: Science
ISBN: 1000147843

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This book explains current strategies for mapping genomes of higher organisms and explores applications of gene mapping to agriculturally important species of plants and animals. It also explores the experimental techniques used for genetic and physical mapping of genes.


The Statistics of Gene Mapping

The Statistics of Gene Mapping
Author: David Siegmund
Publisher: Springer Science & Business Media
Total Pages: 337
Release: 2007-05-27
Genre: Medical
ISBN: 0387496866

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This book details the statistical concepts used in gene mapping, first in the experimental context of crosses of inbred lines and then in outbred populations, primarily humans. It presents elementary principles of probability and statistics, which are implemented by computational tools based on the R programming language to simulate genetic experiments and evaluate statistical analyses. Each chapter contains exercises, both theoretical and computational, some routine and others that are more challenging. The R programming language is developed in the text.