Genome Editing In Neurosciences PDF Download
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Author | : Rudolf Jaenisch |
Publisher | : Springer |
Total Pages | : 129 |
Release | : 2017-09-14 |
Genre | : Medical |
ISBN | : 331960192X |
Download Genome Editing in Neurosciences Book in PDF, ePub and Kindle
This book is open access under a CC BY 4.0 license. CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease. This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.
Author | : Rudolf Jaenisch |
Publisher | : |
Total Pages | : 128 |
Release | : 2020-10-08 |
Genre | : Medical |
ISBN | : 9781013268564 |
Download Genome Editing in Neurosciences Book in PDF, ePub and Kindle
Innovations in molecular biology are allowing neuroscientists to study the brain with unprecedented resolution, from the level of single molecules to integrated gene circuits. Chief among these innovations is the CRISPR-Cas genome editing technology, which has the precision and scalability to tackle the complexity of the brain. This Colloque Médecine et Recherche has brought together experts from around the world that are applying genome editing to address important challenges in neuroscience, including basic biology in model organisms that has the power to reveal systems-level insight into how the nervous system develops and functions as well as research focused on understanding and treating human neurological disorders. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
Author | : Rudolf Jaenisch |
Publisher | : Springer |
Total Pages | : 0 |
Release | : 2018-08-11 |
Genre | : Medical |
ISBN | : 9783319868011 |
Download Genome Editing in Neurosciences Book in PDF, ePub and Kindle
This book is open access under a CC BY 4.0 license. CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease. This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.
Author | : James Giordano |
Publisher | : CRC Press |
Total Pages | : 357 |
Release | : 2012-04-26 |
Genre | : Science |
ISBN | : 1439825866 |
Download Neurotechnology Book in PDF, ePub and Kindle
New technologies that allow us to investigate mechanisms and functions of the brain have shown considerable promise in treating brain disease and injury. These emerging technologies also provide a means to assess and manipulate human consciousness, cognitions, emotions, and behaviors, bringing with them the potential to transform society. Neurotechnology: Premises, Potential, and Problems explores the technical, moral, legal, and sociopolitical issues that arise in and from today’s applications of neuroscience and technology and discusses their implications for the future. Some of the issues raised in this thought-provoking volume include: Neurotechnology in education: an enablement, a treatment, or an enhancement? The potential and limitations of neuroimaging technology in determining patient prognoses Tissue implantation technology as a way of engendering personalized medicine Neuroprostheses: restoration of functions of the disabled vs. enhancement to transhuman capabilities Deep brain stimulation and its use in restoring, preserving, or changing patients’ personal identity The benefit and risk of cognitive performance tools Cyborg technology and its potential to change our vision of humanity Methodologies for reducing the risk of neurotechnology’s impact on ethical, legal, and social issues With contributions from an international group of experts working on the cutting edge of neurotechnology, this volume lays the groundwork to appreciate the ethical, legal, and social aspects of the science in ways that keep pace with this rapidly progressing field.
Author | : Alfred A. Bertelsen |
Publisher | : |
Total Pages | : 0 |
Release | : 2019 |
Genre | : Biotechnology |
ISBN | : 9781536164268 |
Download The CRISPR/Cas9 System Book in PDF, ePub and Kindle
This compilation focuses on the CRISPR/Cas9 system, a genome editing tool that has been hailed as the most profound molecular biology discovery in the past decade. By employing the natural process of bacterial immunity towards bacteriophages, the tool allows researchers to precisely excise and edit parts of the genetic sequence to modify them.The authors summarize the molecular pathogenesis of hepatocellular carcinoma, available treatments/drugs and their limitations, the landscape of CRISPR targeting hepatocellular carcinoma, limitations and potential targets in future.The closing review summarises the use of CRISPR/Cas9 gene editing in ophthalmology and focuses on the advancement of gene editing in the cornea. The majority of corneal dystrophies are the result an autosomal dominant inheritance pattern within the TGFBI gene, which presents an ideal model suited for a CRISPR/Cas9 knock out methodology.
Author | : Simon G Sprecher |
Publisher | : Humana |
Total Pages | : 0 |
Release | : 2013-09-19 |
Genre | : Medical |
ISBN | : 9781627036542 |
Download Brain Development Book in PDF, ePub and Kindle
Providing widely used techniques in genetic model systems and many complementing animal models, Brain Development: Methods and Protocols focuses its expert contributions on two key technical aspects of developmental neurobiology: detection of gene expression and functional characterization of developmental control genes. Covering animal models such as the fruit fly, zebra fish, chicken, and mouse, this detailed book views in situ hybridization, reporter gene expression, and immunohistochemical staining methods, as well as RNA interference, Morpholino, or transgenic techniques through the prism of these models. Written in the highly successful Methods in Molecular Biology series format, chapter include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and cutting-edge, Brain Development: Methods and Protocols aims to provide precise technical protocols but also allows for comparing a wide range of protocols in different tissues and species.
Author | : Mingjie Li |
Publisher | : Academic Press |
Total Pages | : 450 |
Release | : 2018-05-25 |
Genre | : Medical |
ISBN | : 012809821X |
Download Gene Therapy in Neurological Disorders Book in PDF, ePub and Kindle
Gene therapy has tremendous potential for the treatment of neurological disorders. There has been substantial progress in the development of gene therapy strategies for neurological disorders over the last two decades. Gene Therapy in Neurological Disorders thoroughly reviews currently available gene therapy tools and presents examples of their application in a variety of neurological diseases. The book begins with general reviews of gene therapy strategies with a focus on neurological disorders. The remainder of the chapters present approaches to specific neurological disorders. Each chapter gives an in-depth introduction to the relevant field before diving into the specific tool or application. The book aims to help investigators, students and research staff better understand the principles of gene therapy and its application in the nervous system. Provides background information and experimental details of gene therapy tools applied for neuroscience research and neurological disorders Covers a broad range of gene delivery and regulation tools, therapeutic agents, and target cells, including emerging new technologies such as CRISPR/Cas9 genome editing Discusses applications of gene therapy tools to neurological disorders including neurodegeneration, muscular dystrophy, trauma and chronic pain, and neoplastic diseases
Author | : Andrew S. Reynolds |
Publisher | : Cambridge University Press |
Total Pages | : 223 |
Release | : 2022-04-28 |
Genre | : Science |
ISBN | : 110883728X |
Download Understanding Metaphors in the Life Sciences Book in PDF, ePub and Kindle
Introduces the diverse roles metaphors play in the life sciences and highlights their significance for theory, communication, and education.
Author | : Simon G. Sprecher |
Publisher | : Humana |
Total Pages | : 527 |
Release | : 2019-09-26 |
Genre | : Science |
ISBN | : 9781493997312 |
Download Brain Development Book in PDF, ePub and Kindle
This book provides a thorough introduction to widely used techniques for the study of the intersection between developmental biology and neuroscience, an exceptional area to address and investigate impacting biological questions. The fully updated volume examines cutting-edge techniques on a representative range of animals, including widely used genetic model systems, such as the fruit fly, zebra fish, chicken, and mouse, as well as non-canonical experimental systems opened up through the advent of genome editing. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Brain Development: Methods and Protocols, Second Edition is an ideal guide for researchers interested in utilizing recent technical advances in molecular genetics for the study of the brain.
Author | : Georg F. Striedter |
Publisher | : Oxford University Press, USA |
Total Pages | : 541 |
Release | : 2020 |
Genre | : Science |
ISBN | : 0195125681 |
Download Brains Through Time Book in PDF, ePub and Kindle
"Much is conserved in vertebrate evolution, but significant changes in the nervous system occurred at the origin of vertebrates and in most of the major vertebrate lineages. This book examines these innovations and relates them to evolutionary changes in other organ systems, animal behavior, and ecological conditions at the time. The resulting perspective clarifies what makes the major vertebrate lineages unique and helps explain their varying degrees of ecological success. One of the book's major conclusions is that vertebrate nervous systems are more diverse than commonly assumed, at least among neurobiologists. Examples of important innovations include not only the emergence of novel brain regions, such as the cerebellum and neocortex, but also major changes in neuronal circuitry and functional organization. A second major conclusion is that many of the apparent similarities in vertebrate nervous systems resulted from convergent evolution, rather than inheritance from a common ancestor. For example, brain size and complexity increased numerous times, in many vertebrate lineages. In conjunction with these changes, olfactory inputs to the telencephalic pallium were reduced in several different lineages, and this reduction was associated with the emergence of pallial regions that process non-olfactory sensory inputs. These conclusions cast doubt on the widely held assumption that all vertebrate nervous systems are built according to a single, common plan. Instead, the book encourages readers to view both species similarities and differences as fundamental to a comprehensive understanding of nervous systems. Evolution; Phylogeny; Neuroscience; Neurobiology; Neuroanatomy; Functional Morphology; Paleoecology; Homology; Endocast; Brain"--