Genetics Of Asthma And Chronic Obstructive Pulmonary Disease PDF Download
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| Author | : Dirkje S. Postma |
| Publisher | : CRC Press |
| Total Pages | : 456 |
| Release | : 2007 |
| Genre | : Medical |
| ISBN | : |
Download Genetics of Asthma and Chronic Obstructive Pulmonary Disease Book in PDF, ePub and Kindle
Responding to the substantial growth that has taken place in the field over the past decade, this reference provides an in-depth overview of current thought on the genetics and genomics of asthma and COPD in relation to their pathogenesis and treatment. With contributions by an esteemed team of international authorities on the topic, this source spans the latest developments in the utilization of microarray techniques, linkage and association studies, mapping strategies, comparative genetics, microarray techniques, proteomics, and pharmacogenomics.
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| Publisher | : |
| Total Pages | : |
| Release | : 2004 |
| Genre | : |
| ISBN | : |
Download Candidate Gene Association Studies of Chronic Obstructive Pulmonary Disease and Asthma Book in PDF, ePub and Kindle
COPD and asthma are complex diseases characterized by pulmonary inflammation. The roles of single nucleotide polymorphisms (SNPs) in the inflammatory cytokine IL10, IL10RA, CSF2, CSF3 and IL6 in COPD and SNPs in a Th2-polarizing cytokine thymic stromal lymphopoietin (TSLP) in asthma are not clear. Association studies were performed to explore the genetic contribution of these cytokines to COPD or asthma. Housekeeping genes on airway epithelium were also optimized. In the study of COPD in the Lung Health Study (LHS), no association was found for IL10, IL10RA and CSF2; an increase in the number of CSF3 -1719T alleles was associated with protection against low forced expiratory volume in one second (FEV1), odds ratio (OR) = .73, 95% confidence interval (CI) = .56 - .95, P = .018; three IL6 SNPs were associated with the rate of decline of FEV1 (.023 d"P d".041 in additive models). In the National Emphysema Treatment Trial - Normative Aging Study, IL6_-174G/C and four other highly linked SNPs were associated with COPD (.01 d"P d".04 in additive genetic models). Association between IL6 and rate of FEV1 decline was the most statistically significant observations in all of our studies in LHS, which has examined more than 40 candidate genes. In the study of TSLP association with asthma, the A allele of rs1837253 was associated with protection from asthma, atopic asthma, and airway hyperresponsiveness (AHR), with ORs (95% CI) and corrected P values for each being .79 (.69 - .90) and .0058; .75 (.63 - .88) and .0074; and .76 (.64 - .89) and .0094, respectively. These associations were the most statistically significant observations in our study, which has examined 98 candidate genes. Cyclophilin A was identified as the most suitable normalizer in gene expression studies involving human airway epithelium. In summary, we demonstrate for the first time that IL6 SNPs are associated with rapid decline of FEV1 and COPD; TSLP SNPs are associated with asthma and AHR. These results wil.
| Author | : Edwin Silverman |
| Publisher | : CRC Press |
| Total Pages | : 555 |
| Release | : 2005-09-30 |
| Genre | : Medical |
| ISBN | : 0340814322 |
Download Respiratory Genetics Book in PDF, ePub and Kindle
There has been a recent explosion of knowledge in the field of respiratory genetics. This authoritative text brings together current knowledge in respiratory genetics in a single volume. The book includes a comprehensive introductory section to provide guidance and aid understanding of key basic concepts in respiratory genetics, including statistical methods, sample collection, bioinformatics, and functional genomics. This is followed by a series of disease-specific chapters that review epidemiology, natural history, monogenic determinants, complex disease components, disease management, and likely future developments. Respiratory Genetics is an essential reference for pulmonologists, translational researchers, and clinical geneticists, and the text will also be a useful library reference.
| Author | : Peter J. Barnes |
| Publisher | : Elsevier |
| Total Pages | : 897 |
| Release | : 2009-03-19 |
| Genre | : Medical |
| ISBN | : 0080920608 |
Download Asthma and COPD Book in PDF, ePub and Kindle
The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments. * Each chapter considers Asthma and COPD in side-by-side contrast and comparison – not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management * Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD * Most extensive reference to primary literature on both Asthma and COPD in one source. * Easy-to-read summaries of the latest advances alongside clear illustrations
| Author | : Stephen. D. Litwin |
| Publisher | : CRC Press |
| Total Pages | : 305 |
| Release | : 2020-08-13 |
| Genre | : Medical |
| ISBN | : 1000110443 |
Download Genetic Determinants of Pulmonary Disease Book in PDF, ePub and Kindle
This book provides a current and integrated approach to the subject of genetic determinants of pulmonary disease with emphasis on physiologic derangements and genetic mechanisms. It describes the epidemiologic-genetic approach to chronic pulmonary disease.
| Author | : Jonathan A. Bernstein |
| Publisher | : CRC Press |
| Total Pages | : 290 |
| Release | : 2018-03-22 |
| Genre | : Medical |
| ISBN | : 0429765185 |
Download Asthma, COPD, and Overlap Book in PDF, ePub and Kindle
Using illustrative case examples, this book thoroughly reviews similarities and differences between asthma, chronic obstructive pulmonary disease (COPD) and the overlap syndrome. It is important to highlight the distinctions because these commonly encountered conditions in respiratory and primary care share many similarities but have important differences often mistaken for each other. This can have serious implications for treatment, particularly as new treatments are targeted at specific phenotypes of the diseases. This practical guide shows how to distinguish between the diseases on a pathological and clinical basis so that appropriate management and treatment may be pursued.
| Author | : United States. Public Health Service. Office of the Surgeon General |
| Publisher | : |
| Total Pages | : 728 |
| Release | : 2010 |
| Genre | : Government publications |
| ISBN | : |
Download How Tobacco Smoke Causes Disease Book in PDF, ePub and Kindle
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
| Author | : Darcy D. Marciniuk |
| Publisher | : |
| Total Pages | : |
| Release | : 2017 |
| Genre | : |
| ISBN | : 9781849840880 |
Download ˜Theœ Global Impact of Respiratory Disease Book in PDF, ePub and Kindle
| Author | : Garden Grove Garden Grove Press |
| Publisher | : |
| Total Pages | : 188 |
| Release | : 2017-04-05 |
| Genre | : |
| ISBN | : 9781545180945 |
Download Medical Genetics of Asthma Book in PDF, ePub and Kindle
This article collection reviews the medical genetics of asthma and includes 22 papers by various authors. Topics include: Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population; Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population; Respiratory symptoms among infants at risk for asthma: association with surfactant protein A haplotypes; A functional polymorphism in the SPINK5 gene is associated with asthma in a Chinese Han Population; Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han population; Analyses of associations between three positionally cloned asthma candidate genes and asthma or asthma-related phenotypes in a Chinese population; A pooling-based genome-wide analysis identifies new potential candidate genes for atopy in the European Community Respiratory Health Survey (ECRHS); Mechanistic role of a disease-associated genetic variant within the ADAM33 asthma susceptibility gene; Association study between vitamin D receptor gene polymorphisms and asthma in the chinese han population: a case-control study; Evaluation of the toll-like receptor 6 Ser249Pro polymorphism in patients with asthma, atopic dermatitis and chronic obstructive pulmonary disease; Genome Wide Association Study to predict severe asthma exacerbations in children using random forests classifiers; Asthma: Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene as risk factors; Effects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1; Comprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes; Leukotriene B4 receptor locus gene characterisation and association studies in asthma; Vitamin D binding protein variants associate with asthma susceptibility in the Chinese han population; Investigating highly replicated asthma genes as candidate genes for allergic rhinitis; Association of CD14 -260 (-159) C>T and asthma: a systematic review and meta-analysis; The effect of CD14 and TLR4 gene polimorphisms on asthma phenotypes in adult Turkish asthma patients: a genetic study; Genome-wide association study identifies PERLD1 as asthma candidate gene; Large scale genotyping study for asthma in the Japanese population; ITGB5 and AGFG1 variants are associated with severity of airway responsiveness. Proceeds from the sale of this book go to the support of an elderly disabled person.
| Author | : Aili Lazaar |
| Publisher | : CRC Press |
| Total Pages | : 264 |
| Release | : 2006-08-04 |
| Genre | : Medical |
| ISBN | : 1420018450 |
Download Bronchial Vascular Remodeling in Asthma and COPD Book in PDF, ePub and Kindle
Responding to the growth of research in the field over the past decade, this book brings together leading investigators with expertise in pulmonology, pathology, and developmental biology to clarify the mechanisms that regulate the development of bronchial vascular remodeling in asthma and COPD, as well as explore the pathophysiological processes t
