Genetic Manipulation of Streptomyces
Author | : D. A. Hopwood |
Publisher | : |
Total Pages | : 378 |
Release | : 1985 |
Genre | : Gene expression |
ISBN | : |
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Author | : D. A. Hopwood |
Publisher | : |
Total Pages | : 378 |
Release | : 1985 |
Genre | : Gene expression |
ISBN | : |
Author | : David A. Hopwood |
Publisher | : |
Total Pages | : 356 |
Release | : 1985-01-01 |
Genre | : Science |
ISBN | : 9780879699932 |
Author | : Shannon A. Eaton |
Publisher | : |
Total Pages | : 194 |
Release | : 1987 |
Genre | : Genetic engineering |
ISBN | : |
Author | : D. A. Hopwood |
Publisher | : Oxford University Press |
Total Pages | : 261 |
Release | : 2007-02-03 |
Genre | : Medical |
ISBN | : 019515066X |
This is an insiders account of 50 years of genetic studies of the soil-inhabiting microbes that produce most of the antibiotics used to treat infections, as well as anti-cancer, anti-parasitic and immunosuppressant drugs. The book begins by describing how these microbes the actinomycetes were discovered in the latter part of the nineteenth century, but remained a Cinderella group until, in the 1940s, they shot to prominence with the discovery of streptomycin, the first effective treatment for tuberculosis and only the second antibiotic, after penicillin, to become a medical marvel. There followed a massive effort over several decades to find further treatments for infectious diseases and cancer, tempered by the rise of antibiotic resistance consequent on antibiotic misuse and over-use. The book goes on to describe the discovery of gene exchange in the actinomycetes in the context of the rise of microbial genetics in the mid-20th century, leading to determination of the complete DNA sequence of a model member of the group at the turn of the millennium. There follow chapters in which the intricate molecular machinery that adapts the organisms metabolism and development to life in the soil, including antibiotic production, is illuminated by the DNA blueprint. Then come an up-to-the minute account of the use of genetic engineering to make novel, hybrid, antibiotics, and a topical description of techniques to learn the roles of the thousands of genes in a genome sequence, throwing a powerful light on the biology of the organisms and their harnessing for increasing antibiotic productivity. In the final chapter we return to the mycobacteria that cause tuberculosis and leprosy, the first actinomycetes to be discovered, and how methodology, in part derived from the study of the streptomycetes, is being applied to understand and control these still deadly pathogens.
Author | : Pamela Ann Shea |
Publisher | : |
Total Pages | : 190 |
Release | : 1984 |
Genre | : Bacterial genetics |
ISBN | : |
Author | : Anna-Marie E. Brassington |
Publisher | : |
Total Pages | : |
Release | : 2000 |
Genre | : |
ISBN | : |
Author | : Tobias Kieser |
Publisher | : |
Total Pages | : 613 |
Release | : 2000-01-01 |
Genre | : Bacterial genetics |
ISBN | : 9780708406236 |
Author | : Satoshi Omura |
Publisher | : Springer Science & Business Media |
Total Pages | : 373 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 1461244129 |
Biologically active compounds isolated from microorganisms continue to be vital to the development of new drugs and agricultural chemicals. This book was prepared by current and past members of the laboratory of Dr. Satoshi Omura of the Kitasato Institute in Japan. Dr. Omura and his colleagues have discovered and studied a number of important antibiotics, and in their work they have pioneered new methods for screening microbes for interesting and important compounds. This book presents strategies and methods for identifying novel molecules with several types of biological activity. In addition, the book discusses the identification of microbial compounds of agrochemical importance, presents information on chemical screening methods, and concludes with chapters on microbial strain selection, fermentation technology, and genetic engineering of antibiotic-producing microorganisms. This book will be of great interest to scientists working in the very active and competitive fields of antibiotic and agrochemical discovery.
Author | : Masayori Inouye |
Publisher | : Academic Press |
Total Pages | : 330 |
Release | : 2014-06-28 |
Genre | : Science |
ISBN | : 1483273970 |
Experimental Manipulation of Gene Expression discusses a wide range of host systems in which to clone and express a gene of interest. The aims are for readers to quickly learn the versatility of the systems and obtain an overview of the technology involved in the manipulation of gene expression. Furthermore, it is hoped that the reader will learn enough from the various approaches to be able to develop systems and to arrange for a gene of particular interest to express in a particular system. The book opens with a chapter on the design and construction of a plasmid vector system used to achieve high-level expression of a particular phage regulatory protein normally found in minute amounts in a phage-infected bacterial cell. This is followed by separate chapters on topics such as high-level expression vectors that utilize efficient Escherichia coli lipoprotein promoter as well as various other portions of the lipoprotein gene Ipp; DNA cloning systems for streptomycetes; and the design and application of vectors for high-level, inducible synthesis of the product of a cloned gene in yeast.
Author | : Zohreh Hojati Najafabadi |
Publisher | : |
Total Pages | : |
Release | : 2002 |
Genre | : |
ISBN | : |