Genetic And Biological Pathways Underpinning Communication Disorders Across The Lifespan PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Genetic And Biological Pathways Underpinning Communication Disorders Across The Lifespan PDF full book. Access full book title Genetic And Biological Pathways Underpinning Communication Disorders Across The Lifespan.
Author | : Sid P. Bacon |
Publisher | : |
Total Pages | : 62 |
Release | : 2008 |
Genre | : |
ISBN | : |
Download Genetic and Biological Pathways Underpinning Communication Disorders Across the Lifespan Book in PDF, ePub and Kindle
Author | : |
Publisher | : |
Total Pages | : 63 |
Release | : 2008 |
Genre | : |
ISBN | : |
Download ASHA 2007 Research Symposium Book in PDF, ePub and Kindle
Author | : John W. Oller |
Publisher | : Plural Publishing |
Total Pages | : 785 |
Release | : 2009-07-01 |
Genre | : Medical |
ISBN | : 1597567744 |
Download Cases Book in PDF, ePub and Kindle
Author | : Heather A Voss-Hoynes (Voss-Hoynes) |
Publisher | : |
Total Pages | : 231 |
Release | : 2017 |
Genre | : Biometry |
ISBN | : |
Download Dissecting the Genetics of Human Communication Book in PDF, ePub and Kindle
Interpersonal communication is a vital component of everyday life which can be negatively affected by speech sound disorders (SSD). SSD affect articulation and phonological processes, are the most common type of communication disorder, and occur in 16% of three year olds. Despite the frequency with which they occur, SSD are relatively understudied compared to other communication disorders such as dyslexia and specific language impairment. SSD can occur due to craniofacial abnormalities, hearing loss, as a symptom of certain syndromes, or due to unknown causes. SSD of unknown cause are heritable with monozygotic twin concordance rates of 0.95, but the genetic basis is not well defined. Many previous studies have focused upon FOXP2, a gene harboring a causal mutation in one large family, or genes and loci associated with language impairment (LI) or dyslexia (RD), frequently comorbid conditions. The weakness of these approaches is they are self-limiting and cannot identify novel loci. Consequently, it would be beneficial to address the etiology of SSD agnostically to identify novel loci and characterize the genetic architecture of what is likely a multifactorial disorder. To do so, data from the Cleveland Family Speech and Reading Study, a longitudinal study of children with SSD, were used to perform the first known genome-wide association study on traits associated with SSD endophenotypes in a sample ascertained based on speech sound disorder diagnosis. This analysis identified novel loci, replicated previous findings, and informed hypotheses regarding biological pathways that may be involve in SSD. To investigate the impact of LI and RD on genetic association with SSD endophenotypes, the changes in genetic effect estimates after adjusting for the conditions were analyzed. Some effects were unchanged by LI and RD status suggesting a foundational role of these loci in human communication. Finally a pathway analysis revealed similarities between SSD and other neuropathologies such as autism spectrum disorders and Alzheimer's disease. This study represents a thorough examination of the genetic underpinnings of SSD and other communication traits, is the first genome-wide association study for SSD, and supports a multifactorial genetic architecture underlying both typical and atypical communication.
Author | : |
Publisher | : |
Total Pages | : 790 |
Release | : 2008 |
Genre | : Language and languages |
ISBN | : |
Download Linguistics and Language Behavior Abstracts Book in PDF, ePub and Kindle
Author | : Bernhard Baune |
Publisher | : Academic Press |
Total Pages | : 604 |
Release | : 2019-10-16 |
Genre | : Medical |
ISBN | : 0128131772 |
Download Personalized Psychiatry Book in PDF, ePub and Kindle
Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders. Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective
Author | : Joao Quevedo |
Publisher | : Academic Press |
Total Pages | : 472 |
Release | : 2020-11-25 |
Genre | : Medical |
ISBN | : 012819183X |
Download Neurobiology of Bipolar Disorder Book in PDF, ePub and Kindle
The Neurobiology of Bipolar Disorder: Road to Novel Therapeutics combines the basic neurobiology of bipolar disorder with discussions of the most recent advances in research, including the interacting pathways implicated in the pathophysiology of bipolar disorder, genetic approaches and the pharmacogenomics of bipolar disorder. The basic foundational understanding of the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research combine to aid advanced students and researchers in their understanding of bipolar disorder management using novel and fast-acting pharmaceutical and neuromodulatory approaches. Aids readers in understanding bipolar disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments to novel therapeutics Synthesizes a discussion of the cellular and molecular mechanisms underlying symptoms with clinical aspects of bipolar disorder
Author | : Institute of Medicine |
Publisher | : National Academies Press |
Total Pages | : 336 |
Release | : 2004-10-18 |
Genre | : Social Science |
ISBN | : 0309166608 |
Download Children's Health, the Nation's Wealth Book in PDF, ePub and Kindle
Children's health has clearly improved over the past several decades. Significant and positive gains have been made in lowering rates of infant mortality and morbidity from infectious diseases and accidental causes, improved access to health care, and reduction in the effects of environmental contaminants such as lead. Yet major questions still remain about how to assess the status of children's health, what factors should be monitored, and the appropriate measurement tools that should be used. Children's Health, the Nation's Wealth: Assessing and Improving Child Health provides a detailed examination of the information about children's health that is needed to help policy makers and program providers at the federal, state, and local levels. In order to improve children's health-and, thus, the health of future generations-it is critical to have data that can be used to assess both current conditions and possible future threats to children's health. This compelling book describes what is known about the health of children and what is needed to expand the knowledge. By strategically improving the health of children, we ensure healthier future generations to come.
Author | : Neal Halfon |
Publisher | : Springer |
Total Pages | : 667 |
Release | : 2017-11-20 |
Genre | : Medical |
ISBN | : 3319471430 |
Download Handbook of Life Course Health Development Book in PDF, ePub and Kindle
This book is open access under a CC BY 4.0 license. This handbook synthesizes and analyzes the growing knowledge base on life course health development (LCHD) from the prenatal period through emerging adulthood, with implications for clinical practice and public health. It presents LCHD as an innovative field with a sound theoretical framework for understanding wellness and disease from a lifespan perspective, replacing previous medical, biopsychosocial, and early genomic models of health. Interdisciplinary chapters discuss major health concerns (diabetes, obesity), important less-studied conditions (hearing, kidney health), and large-scale issues (nutrition, adversity) from a lifespan viewpoint. In addition, chapters address methodological approaches and challenges by analyzing existing measures, studies, and surveys. The book concludes with the editors’ research agenda that proposes priorities for future LCHD research and its application to health care practice and health policy. Topics featured in the Handbook include: The prenatal period and its effect on child obesity and metabolic outcomes. Pregnancy complications and their effect on women’s cardiovascular health. A multi-level approach for obesity prevention in children. Application of the LCHD framework to autism spectrum disorder. Socioeconomic disadvantage and its influence on health development across the lifespan. The importance of nutrition to optimal health development across the lifespan. The Handbook of Life Course Health Development is a must-have resource for researchers, clinicians/professionals, and graduate students in developmental psychology/science; maternal and child health; social work; health economics; educational policy and politics; and medical law as well as many interrelated subdisciplines in psychology, medicine, public health, mental health, education, social welfare, economics, sociology, and law.
Author | : Gregory O'Brien |
Publisher | : Cambridge University Press |
Total Pages | : 236 |
Release | : 1995 |
Genre | : Medical |
ISBN | : 9781898683063 |
Download Behavioural Phenotypes Book in PDF, ePub and Kindle
A timely distillation of current thinking on the presentation of behavioural disorders and their origins.