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Félix d`Herelle and the Origins of Molecular Biology

Félix d`Herelle and the Origins of Molecular Biology
Author: William C. Summers
Publisher: Yale University Press
Total Pages: 272
Release: 1999-06-10
Genre: Biography & Autobiography
ISBN: 9780300174250

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A self-taught scientist determined to bring science out of the laboratory and into the practical arena, French-Canadian Felix d’Herelle (1873-1949) made history in two different fields of biology. Not only was he first to demonstrate the use and application of bacteria for biological control of insect pests, he also became a seminal figure in the history of molecular biology. This engaging book is the first full biography of d’Herelle, a complex figure who emulated Louis Pasteur and influenced the course of twentieth-century biology, yet remained a controversial outsider to the scientific community. Drawing on family papers, archival sources, interviews, and d’Herelle’s published and unpublished writings, Dr. William C. Summers tells the fascinating story of the scientist’s life and the work that took him around the globe. In 1917, d’Herelle published the first paper describing the phenomenon of the bacteriophage and its biological nature. A series of more than 110 articles and 6 major books followed, in which d’Herelle established the foundation for the later work of the Phage Group in molecular biology. Yet d’Herelle sometimes inspired animosity in others--he was drummed out of the Pasteur Institute, he held only one brief permanent position in the scientific establishment (at Yale University from 1928 to 1933), and he was bewildered by the social nuances of the world of international science. His story is more than the biography of a single brilliant scientist; it is also a fascinating chapter in the history of biology.


Felix D'Herelle and the Origins of Molecular Biology

Felix D'Herelle and the Origins of Molecular Biology
Author: William Summers
Publisher:
Total Pages: 230
Release: 2007-12
Genre:
ISBN: 9781422353585

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A self-taught scientist determined to bring science out of the lab. & into the practical arena, d¿Herelle (1873-1949) made history in 2 different fields of biology. He was first to demonstrate the use & application of bacteria for biological control of insect pests, & also became a seminal figure in the history of molecular biology. d¿Herelle was a complex figure who emulated Louis Pasteur & influenced the course of 20th-century biology, yet remained a controversial outsider to the scientific community. Summers tells the fascinating story of the scientist¿s life & the work that took him around the globe. ¿This biography of a single brilliant scientist is also a fascinating chapter in the history of biology.¿ ¿Marvelous historical sensibility.¿ Illustrations


Arrowsmith

Arrowsmith
Author: Sinclair Lewis
Publisher: Simon and Schuster
Total Pages: 390
Release: 2021-03-23
Genre: Fiction
ISBN: 1649741286

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Arrowsmith has been inspirational for several generations of med students. Martin Arrowsmith agonizes over his career and life decisions never sure if he’s making the correct descisions. While the book details Arrowsmith's pursuit of the noble ideals of medical research for the benefit of mankind and of selfless devotion to the care of patients, Lewis throws many less noble temptations and self deceptions in Arrowsmith’s path. The attractions of financial security, recognition, even wealth and power distract Arrowsmith from his original plan to follow in the footsteps of his first mentor, Max Gottlieb, a brilliant but abrasive bacteriologist. A powerful novel that asks more questions than it answers. Winner of the Pulitzer Prize.


The Perfect Predator

The Perfect Predator
Author: Steffanie Strathdee
Publisher: Hachette Books
Total Pages: 346
Release: 2019-02-26
Genre: Science
ISBN: 0316418072

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An electrifying memoir of one woman's extraordinary effort to save her husband's life-and the discovery of a forgotten cure that has the potential to save millions more. "A memoir that reads like a thriller." -New York Times Book Review "A fascinating and terrifying peek into the devastating outcomes of antibiotic misuse-and what happens when standard health care falls short." -Scientific American Epidemiologist Steffanie Strathdee and her husband, psychologist Tom Patterson, were vacationing in Egypt when Tom came down with a stomach bug. What at first seemed like a case of food poisoning quickly turned critical, and by the time Tom had been transferred via emergency medevac to the world-class medical center at UC San Diego, where both he and Steffanie worked, blood work revealed why modern medicine was failing: Tom was fighting one of the most dangerous, antibiotic-resistant bacteria in the world. Frantic, Steffanie combed through research old and new and came across phage therapy: the idea that the right virus, aka "the perfect predator," can kill even the most lethal bacteria. Phage treatment had fallen out of favor almost 100 years ago, after antibiotic use went mainstream. Now, with time running out, Steffanie appealed to phage researchers all over the world for help. She found allies at the FDA, researchers from Texas A&M, and a clandestine Navy biomedical center -- and together they resurrected a forgotten cure. A nail-biting medical mystery, The Perfect Predator is a story of love and survival against all odds, and the (re)discovery of a powerful new weapon in the global superbug crisis.


A Tale of Two Viruses

A Tale of Two Viruses
Author: Neeraja Sankaran
Publisher: University of Pittsburgh Press
Total Pages: 410
Release: 2021-03-09
Genre: Science
ISBN: 0822987716

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In 1965, French microbiologist André Lwoff was awarded the Nobel Prize in Physiology or Medicine for his work on lysogeny—one of the two types of viral life cycles—which resolved a contentious debate among scientists about the nature of viruses. A Tale of Two Viruses is the first study of medical virology to compare the history of two groups of medically important viruses—bacteriophages, which infect bacteria, and sarcoma agents, which cause cancer—and the importance of Lwoff’s discovery to our modern understanding of what a virus is. Although these two groups of viruses may at first glance appear to have little in common, they share uniquely parallel histories. The lysogenic cycle, unlike the lytic, enables viruses to replicate in the host cell without destroying it and to remain dormant in a cell’s genetic material indefinitely, or until induced by UV radiation. But until Lwoff’s discovery of the mechanism of lysogeny, microbiologist Félix d’Herelle and pathologist Peyton Rous, who themselves first discovered and argued for the viral identity of bacteriophages and certain types of cancer, respectively, faced opposition from contemporary researchers who would not accept their findings. By following the research trajectories of the two virus groups, Sankaran takes a novel approach to the history of the development of the field of medical virology, considering both the flux in scientific concepts over time and the broader scientific landscapes or styles that shaped those ideas and practices.


Bacteriophages

Bacteriophages
Author: David R. Harper
Publisher: Springer Nature
Total Pages: 1376
Release: 2021-01-30
Genre: Medical
ISBN: 3319419862

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This first major reference work dedicated to the mannifold industrial and medical applications of bacteriophages provides both theoretical and practical insights into the emerging field of bacteriophage biotechnology. The book introduces to bacteriophage biology, ecology and history and reviews the latest technologies and tools in bacteriophage detection, strain optimization and nanotechnology. Usage of bacteriophages in food safety, agriculture, and different therapeutic areas is discussed in detail. This book serves as essential guide for researchers in applied microbiology, biotechnology and medicine coming from both academia and industry.


We Can Sleep Later

We Can Sleep Later
Author: Alfred Day Hershey
Publisher: CSHL Press
Total Pages: 396
Release: 2000
Genre: Biography & Autobiography
ISBN: 9780879695675

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An absorbing portrait of the pioneering molecular biologist best known for demonstrating that DNA is the genetic component of phages, through essays and reminiscences from twenty–three distinguished scientists whose work and careers were influenced by the man and his science.


Current Protocols Essential Laboratory Techniques

Current Protocols Essential Laboratory Techniques
Author: Sean R. Gallagher
Publisher: John Wiley & Sons
Total Pages: 679
Release: 2012-03-19
Genre: Science
ISBN: 047094241X

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The latest title from the acclaimed Current Protocols series, Current Protocols Essential Laboratory Techniques, 2e provides the new researcher with the skills and understanding of the fundamental laboratory procedures necessary to run successful experiments, solve problems, and become a productive member of the modern life science laboratory. From covering the basic skills such as measurement, preparation of reagents and use of basic instrumentation to the more advanced techniques such as blotting, chromatography and real-time PCR, this book will serve as a practical reference manual for any life science researcher. Written by a combination of distinguished investigators and outstanding faculty, Current Protocols Essential Laboratory Techniques, 2e is the cornerstone on which the beginning scientist can develop the skills for a successful research career.


A Machine to Make a Future

A Machine to Make a Future
Author: Paul Rabinow
Publisher: Princeton University Press
Total Pages: 220
Release: 2005
Genre: Business & Economics
ISBN: 9780691120508

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This fascinating book opens up a huge number of questions about how social scientists, anthropologists, or science studies practitioners write about science, scientists, technology, and innovation.


A History of Molecular Biology

A History of Molecular Biology
Author: Michel Morange
Publisher: Harvard University Press
Total Pages: 350
Release: 2000
Genre: History
ISBN: 9780674001695

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Every day it seems the media focus on yet another new development in biology--gene therapy, the human genome project, the creation of new varieties of animals and plants through genetic engineering. These possibilities have all emanated from molecular biology. A History of Molecular Biology is a complete but compact account for a general readership of the history of this revolution. Michel Morange, himself a molecular biologist, takes us from the turn-of-the-century convergence of molecular biology's two progenitors, genetics and biochemistry, to the perfection of gene splicing and cloning techniques in the 1980s. Drawing on the important work of American, English, and French historians of science, Morange describes the major discoveries--the double helix, messenger RNA, oncogenes, DNA polymerase--but also explains how and why these breakthroughs took place. The book is enlivened by mini-biographies of the founders of molecular biology: Delbrück, Watson and Crick, Monod and Jacob, Nirenberg. This ambitious history covers the story of the transformation of biology over the last one hundred years; the transformation of disciplines: biochemistry, genetics, embryology, and evolutionary biology; and, finally, the emergence of the biotechnology industry. An important contribution to the history of science, A History of Molecular Biology will also be valued by general readers for its clear explanations of the theory and practice of molecular biology today. Molecular biologists themselves will find Morange's historical perspective critical to an understanding of what is at stake in current biological research.