Fast Facts For Patients Non Small Cell Lung Cancer With Kras Mutation PDF Download
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Author | : Anne-Marie Baird |
Publisher | : Karger Medical and Scientific Publishers |
Total Pages | : 39 |
Release | : 2023-03-31 |
Genre | : Medical |
ISBN | : 3318072494 |
Download Fast Facts for Patients: Non-small Cell Lung Cancer with KRAS Mutation Book in PDF, ePub and Kindle
Non-small cell lung cancer (NSCLC) is one of two main types of lung cancer. Some lung cancers spread to other parts of the body before they are diagnosed. A cancer that has spread is called ‘metastatic’. New lung cancer treatments are being developed that directly target the gene mutations that control how cancers grow and spread. The most important gene mutations in cancer are called ‘driver mutations’. In NSCLC, this includes KRAS mutations, which can be used as targets for treatment. There are new treatments designed for lung cancers with a KRAS mutation that are already available. And more are being developed. Treatments in development are tested in clinical trials. There are several different phases of clinical trials that people with cancer can take part in. This booklet aims to help patients with NSCLC understand their options so that they can talk to their doctors, nurses, and medical team about their cancer and its treatment. Table of Contents: • What is non-small cell lung cancer? • How can lung cancer develop? • What is metastatic NSCLC? • More about genes and cancer • Oncogenes and cancer • Driver mutations and biomarkers • How your doctor knows your cancer is KRAS-positive • More about KRAS • What does having a KRAS-positive cancer mean for me? • Talking to your doctor about your treatment • About clinical trials and research • Finding further information and support
Author | : A.-M. Baird |
Publisher | : Karger Medical and Scientific Publishers |
Total Pages | : 39 |
Release | : 2023-03-09 |
Genre | : Medical |
ISBN | : 331807277X |
Download Fast Facts for Patients: Non-small Cell Lung Cancer with KRAS Mutation Book in PDF, ePub and Kindle
Non-small cell lung cancer (NSCLC) is one of two main types of lung cancer. Some lung cancers spread to other parts of the body before they are diagnosed. A cancer that has spread is called ‘metastatic’. New lung cancer treatments are being developed that directly target the gene mutations that control how cancers grow and spread. The most important gene mutations in cancer are called ‘driver mutations’. In NSCLC, this includes KRAS mutations, which can be used as targets for treatment. There are new treatments designed for lung cancers with a KRAS mutation that are already available. And more are being developed. Treatments in development are tested in clinical trials. There are several different phases of clinical trials that people with cancer can take part in. This booklet aims to help patients with NSCLC understand their options so that they can talk to their doctors, nurses, and medical team about their cancer and its treatment. Table of Contents: • What is non-small cell lung cancer? • How can lung cancer develop? • What is metastatic NSCLC? • More about genes and cancer • Oncogenes and cancer • Driver mutations and biomarkers • How your doctor knows your cancer is KRAS-positive • More about KRAS • What does having a KRAS-positive cancer mean for me? • Talking to your doctor about your treatment • About clinical trials and research • Finding further information and support
Author | : Mary O'Brien |
Publisher | : Karger Medical and Scientific Publishers |
Total Pages | : 148 |
Release | : 2022-02-28 |
Genre | : Medical |
ISBN | : 3318070106 |
Download Fast Facts: Non-Small-Cell Lung Cancer Book in PDF, ePub and Kindle
Despite an overall decrease in tobacco use, lung cancer (80–85% of which is non-small-cell lung cancer [NSCLC]) is still the leading cause of cancer death in both men and women worldwide. Annual low-dose CT screening of high-risk individuals has the potential to detect early-stage tumors, which can usually be successfully treated with a combination of surgery, radiotherapy and chemotherapy and, in some cases, targeted therapy. However, most patients with NSCLC still present with advanced or metastatic disease. For these patients, initial therapy is guided by the tumor’s molecular characteristics and patient’s performance status. Targeted therapies have significantly improved clinical outcomes and, for some patients with no targetable genetic alterations, immunotherapy has demonstrated significant overall survival benefit. This insightful guide is designed to bring you up to speed with the latest developments and is important reading for all health professionals and medical trainees working in this fast-moving field. Table of Contents: • Prevention and screening • Diagnosis and staging • Surgery • Radiotherapy • Systemic therapy in non-metastatic NSCLC • Systemic therapy in advanced-stage/metastatic disease without a molecular driver • Personalized treatment in advanced NSCLC • Oligometastatic disease and brain metastases
Author | : Rona Yaeger |
Publisher | : Karger Medical and Scientific Publishers |
Total Pages | : 41 |
Release | : 2024-03-20 |
Genre | : Medical |
ISBN | : 3318072907 |
Download Fast Facts for Patients: Colorectal Cancer with KRAS Mutation Book in PDF, ePub and Kindle
Colorectal cancer (CRC) is cancer that begins in the colon or rectum of the digestive system. KRAS is a protein that sends signals to cells telling them to divide. In healthy cells, KRAS can be switched on and off. In some cancer cells, gene mutations cause changes in the KRAS protein that mean it is constantly switched on, driving cells to divide. KRAS mutation status can be used to guide treatment decisions. New treatments that target a KRAS mutation have been approved for non-small cell lung cancer and are now being tested for CRC. Other treatments are also being developed.
Author | : M. O'Brien |
Publisher | : Karger Medical and Scientific Publishers |
Total Pages | : 148 |
Release | : 2022-03-16 |
Genre | : Medical |
ISBN | : 3318070882 |
Download Fast Facts: Non-Small-Cell Lung Cancer Book in PDF, ePub and Kindle
Despite an overall decrease in tobacco use, lung cancer (80–85% of which is non-small-cell lung cancer [NSCLC]) is still the leading cause of cancer death in both men and women worldwide. Annual low-dose CT screening of high-risk individuals has the potential to detect early-stage tumors, which can usually be successfully treated with a combination of surgery, radiotherapy, and chemotherapy and, in some cases, targeted therapy. However, most patients with NSCLC still present with advanced or metastatic disease. For these patients, initial therapy is guided by the tumor’s molecular characteristics and patient’s performance status. Targeted therapies have significantly improved clinical outcomes and, for some patients with no targetable genetic alterations, immunotherapy has demonstrated significant overall survival benefit. This insightful guide is designed to bring you up to speed with the latest developments and is important reading for all health professionals and medical trainees working in this fast-moving field. Table of Contents: • Prevention and screening • Diagnosis and staging • Surgery • Radiotherapy • Systemic therapy in non-metastatic NSCLC • Systemic therapy in advanced-stage/metastatic disease without a molecular driver • Personalized treatment in advanced NSCLC • Oligometastatic disease and brain metastases
Author | : Marianne Davies |
Publisher | : Springer |
Total Pages | : 120 |
Release | : 2019-07-16 |
Genre | : Medical |
ISBN | : 3030165507 |
Download Targeted Therapies in Lung Cancer: Management Strategies for Nurses and Practitioners Book in PDF, ePub and Kindle
This book aims to educate nurses and advanced practice providers (APP’s) about known mutations, availability of targeted therapy and the management of patients with non-small cell lung cancer (NSCLC). It will educate nurses and practitioners about the scope of therapy to assure safe and effective lung cancer treatment. In this era of personalized medicine, nurses and APP’s are responsible for guiding patients from diagnosis through treatment. This starts with the identification of patients that can benefit from these therapies, the key role of biopsy acquisition (ie. what to test, when and how often) and treatment selection based on the mutation identified. Readers will learn about the mechanisms of action, administration, potential adverse side effects and unique management strategies for these targeted agents. Lung cancer continues to be the leading cause of cancer death in the United States and worldwide. Recent advances in the identification of specific oncogenic mutations that drive cancer development, growth and metastasis have led to major paradigm shifts in lung cancer treatment. Sophisticated methods are required to identify specific mutations at the time of diagnosis. This book explains how molecularly targeted therapies have been developed that target these drivers. To date, several tyrosine kinase inhibitors have been approved to target the epidermal growth factor receptor (EGFR), EML4-ALK ,ROS1 and BRAF. Most recently, immune checkpoint inhibitors have been approved with some indication that efficacy may be enhanced for patients who overexpress PD-L1. While some driver mutations have been identified, there is ongoing investigation into additional mutations. In the case of driver mutations, lung cancers will develop resistance to therapy. This book provides nurses and APP’s with the mechanisms of resistance that have been identified such as T790 mutation and many others in the EGFR mutation, and shows how the next level of drug development is focused on identifying mechanisms of resistance and development of new agents that overcome these mutations. With this book in hand, nurses and practitioners will be able to navigate patients through this ever expanding field of lung cancer treatment.
Author | : Philip T. Cagle |
Publisher | : Springer Science & Business Media |
Total Pages | : 217 |
Release | : 2012-06-14 |
Genre | : Medical |
ISBN | : 1461431972 |
Download Molecular Pathology of Lung Cancer Book in PDF, ePub and Kindle
As with other books in the Molecular Pathology Library Series, Molecular Pathology of Lung Cancer bridges the gap between the molecular specialist and the clinical practitioner, including the surgical pathologist who now has a key role in decisions regarding molecular targeted therapy for lung cancer. Molecular Pathology of Lung Cancer provides the latest information and current insights into the molecular basis for lung cancer, including precursor and preinvasive lesions, molecular diagnosis, molecular targeted therapy, molecular prognosis, molecular radiology and related fields for lung cancer generally and for the specific cell types. As many fundamental concepts about lung cancer have undergone revision in only the past few years, this book will likely be the first to comprehensively cover the new molecular pathology of lung cancer. It provides a foundation in this field for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, thoracic radiologists and their trainees, physician assistants, and nursing staff.
Author | : Christian Manegold |
Publisher | : |
Total Pages | : 190 |
Release | : 2010 |
Genre | : Lungs |
ISBN | : 9783837412567 |
Download Non-small Cell Lung Cancer Treatment Book in PDF, ePub and Kindle
Author | : United States. Public Health Service. Office of the Surgeon General |
Publisher | : |
Total Pages | : 728 |
Release | : 2010 |
Genre | : Government publications |
ISBN | : |
Download How Tobacco Smoke Causes Disease Book in PDF, ePub and Kindle
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author | : Aamir Ahmad |
Publisher | : Springer |
Total Pages | : 236 |
Release | : 2015-12-14 |
Genre | : Medical |
ISBN | : 3319242237 |
Download Lung Cancer and Personalized Medicine Book in PDF, ePub and Kindle
This, the first of two volumes on personalized medicine in lung cancer, touches on the core issues related to the understanding of lung cancer—statistics and epidemiology of lung cancer—along with the incidence of lung cancer in non-smokers. A major focus of this volume is the state of current therapies against lung cancer—immune, targeted therapies against EGFR TKIs, KRAS, ALK, angiogenesis; the associated challenges, especially resistance mechanisms; and recent progress in targeted drug development based on metal chemistry. Chapters are written by some of the leading experts in the field, who provide a better understanding of lung cancer, the factors that make it lethal, and current research focused on developing personalized treatment plans. With a unique mix of topics, this volume summarizes the current state-of-knowledge on lung cancer and the available therapies.