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Factors Influencing Use of Pre-Exposure Prophylaxis

Factors Influencing Use of Pre-Exposure Prophylaxis
Author: Justin Terry-Smith
Publisher:
Total Pages: 0
Release: 2020-12-26
Genre:
ISBN: 9781716297540

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Prevention is key to keeping men who have sex with men (MSM) protected from HIV. Despite new and innovative HIV prevention resources such as pre-exposure prophylaxis (PrEP), factors such as education level, employment status, number of sexual partners, and access to health resources may inhibit certain populations from using it. The purpose of this cross-sectional study was to examine the association between education level, employment status, number of sexual partners, and access to health resources and the use of PrEP among MSM.


Individual and Social Network Influences on Potential Use of Pre-exposure Prophylaxis for HIV Prevention Among Adult Black Women

Individual and Social Network Influences on Potential Use of Pre-exposure Prophylaxis for HIV Prevention Among Adult Black Women
Author: Whitney Chivonne Sewell
Publisher:
Total Pages: 195
Release: 2019
Genre: Electronic dissertations
ISBN:

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Oral daily pre-exposure prophylaxis (PrEP) is a single tablet that is >90% effective in reducing HIV transmission among women. Despite evidence of PrEP's efficacy and safety, levels of awareness, prescription, and uptake of PrEP among Black women are disproportionately low. There is evidence suggesting that the influence of peers and sexual partners in the social networks of Black women are potential facilitators and barriers to the intent to use PrEP. However, there has been limited study examining how these individual and social network level factors influence the intent to use PrEP in this population. This dissertation collected used survey data from Black women, aged 18-44, to conduct advanced statistical analysis, including social network analysis, to identify critical individual and network level factors that influence PrEP uptake. This study found strong associations between PrEP support from sexual partners and healthcare providers and intent to use PrEP in this sample. This study builds upon existing research on PrEP and women by contributing to discussions about the importance of social connections in making the decision to engage in PrEP care and services.


Adolescents and AIDS

Adolescents and AIDS
Author: Ralph J. DiClemente
Publisher: SAGE Publications, Incorporated
Total Pages: 102
Release: 1992-07-06
Genre: Medical
ISBN:

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There hasn't been a resource to inform readers about the HIV risk confronting our adolescent population--until now! In Adolescents and AIDS, leading researchers in health, medicine, sociology, and psychology describe the risks to this vulnerable population. Divided into three parts (epidemiology, prevention/risk reduction, and policy), this comprehensive book addresses not only adolescents in general, but includes specific chapters on high-risk populations such as minority, incarcerated and homeless youth. The authors explore the data and theoretical underpinnings necessary for designing and implementing effective risk-reduction and prevention programs by approaching the AIDS epidemic as a social and developmental crisis that adolescents are ill-prepared to address. While proposing appropriate theoretical models for behavior change, the book also evaluates the effectiveness of various intervention strategies ranging from school-based programs to mass-media approaches and offers public policy recommendations for intervening for this population. Health professionals, researchers, policy analysts, clinicians, counselors, and students will find this timely text a valuable resource.


Disease Control Priorities, Third Edition (Volume 6)

Disease Control Priorities, Third Edition (Volume 6)
Author: King K. Holmes
Publisher: World Bank Publications
Total Pages: 1027
Release: 2017-11-06
Genre: Medical
ISBN: 1464805253

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Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.


Understanding Factors that Influence Pre-exposure Prophylaxis Efficacy for HIV-1 Prevention

Understanding Factors that Influence Pre-exposure Prophylaxis Efficacy for HIV-1 Prevention
Author: Pamela M. Murnane
Publisher:
Total Pages: 81
Release: 2014
Genre:
ISBN:

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Pre-exposure prophylaxis (PrEP) is a promising new HIV-1 prevention strategy, with demonstrated efficacy from four randomized clinical trials. However, two trials of PrEP, both among heterosexual African women, did not find efficacy for protection against HIV-1. While adherence to PrEP has been proposed as the primary driver of the range of results across trials, other factors warrant investigation. This dissertation work contributes to our understanding of behavioral and biological factors that influence the effectiveness of PrEP and aims to inform PrEP implementation strategies. This dissertation was conducted within the Partners PrEP Study, a placebo-controlled, randomized trial of daily oral PrEP among 4747 heterosexual HIV-1 serodiscordant couples (one partner is infected with HIV-1 and the other partner is uninfected) in Kenya and Uganda which demonstrated high efficacy for two daily oral PrEP regimens, tenofovir alone and co-formulated tenofovir-emtricitabine. In a series of secondary analyses of data from the Partners PrEP Study, we evaluated the effect of PrEP among high-risk subgroups to determine whether efficacy was sustained in the context of high HIV exposure, we estimated the causal effect of PrEP when adherence was estimated to be high by applying multiple methods to correct for non-adherence in randomized trials, and we assessed whether PrEP adversely impacted hormonal contraceptive effectiveness for pregnancy prevention, as young women are a priority population for HIV prevention. The work presented here supports the hypothesis that the key driver of divergent PrEP trial results was adherence, and indicates that oral PrEP is highly effective for women and men, reducing HIV-1 risk by over 80% when estimated to have been used with high adherence. These analyses contribute to a more nuanced understanding of how PrEP works and inform guidelines for initiating PrEP among persons at risk of HIV-1 acquisition.


HIV Prevalence Estimates from the Demographic and Health Surveys

HIV Prevalence Estimates from the Demographic and Health Surveys
Author:
Publisher:
Total Pages: 32
Release: 2010
Genre: HIV infections
ISBN:

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This report summarizes the HIV prevalence estimates provided in MEASURE Demographic and Health Surveys. The MEASURE DHS project is implemented by ICF Macro, and ICF International Company, and funded by the United States Agency for International Development (USAID).


Rose's Strategy of Preventive Medicine

Rose's Strategy of Preventive Medicine
Author: Geoffrey Arthur Rose
Publisher:
Total Pages: 190
Release: 2008
Genre: Medical
ISBN: 0192630970

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The Strategy of Preventive Medicine by Geoffrey Rose, first published in 1993, remains a key text for anyone involved in preventive medicine. Rose's insights into the inextricable relationship between ill health, or deviance, in individuals and populations they come from, have transformed our whole approach to strategies for improving health. His personal and unique book, based on many years research, sets out the case that the essential determinants of the health of society are to be found in its mass characteristics. The deviant minority can only be understood when seen in its societal context, and effective prevention requires changes which involve the population as a whole. He explores the options for prevention, considering them from various viewpoints - theoretical and scientific, sociological and political, practical and ethical. The applications of his ideas are illustrated by a variety of examples ranging from heart disease to alcoholism to road accidents. His pioneering work focused on a population wide approach to the prevention of common medical and behavioral disorders has become the classic text on the subject. This reissue brings the original text to a new generation involved in preventive medicine. Kay-Tee Khaw and Michael Marmot retain the original text intact, but have added their own perspective on the work. They examine what relevance Rose's ideas might have in the era of the human genome project and other major scientific advances, they consider examples of how the theory might be applied and generalised in medicine and beyond, and discuss what implications it holds for the future. There is also an explanation of the population perspective, clarifying the often confused thinking and arguments about determinants of individual cases and determinants of population incidence. Rose's Strategy of Preventive Medicine will ensure that this seminal work continues to be read by future generations.


Handbook of Antimicrobial Resistance

Handbook of Antimicrobial Resistance
Author: Matthias Gotte
Publisher: Springer
Total Pages: 0
Release: 2018-02-12
Genre: Medical
ISBN: 9781493906932

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While many volumes have been written about various aspects of antimicrobial resistance, this book is a comprehensive reference work. All manifestations of resistance are addressed: viral; bacterial, parasitical and fungal are given dedicated sections. The underlining molecular mechanisms, which depend not only on the microbe but on the specific drug (target), are highly diverse. This work discusses and compares the biological, biochemical and structural aspects of resistance and its evolution.