Experimental Neurotoxicology Methods PDF Download
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Author | : Jordi Llorens |
Publisher | : Springer Nature |
Total Pages | : 488 |
Release | : 2021-07-23 |
Genre | : Medical |
ISBN | : 1071616374 |
Download Experimental Neurotoxicology Methods Book in PDF, ePub and Kindle
This volume explores the latest methods that seek to address the vital questions being asked in neurotoxicology research. The chapters in this book cover a variety of available methods from the molecular level to the organism level, and both in vitro and in vivo approaches, including alternative model organisms. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Experimental Neurotoxicology Methods is a valuable resource for both young and experienced researchers who are looking for guidance to implement these methods in their laboratories or for understanding the data generated through these techniques.
Author | : V. Pentreath |
Publisher | : CRC Press |
Total Pages | : 314 |
Release | : 1999-05-27 |
Genre | : Medical |
ISBN | : 9780748403882 |
Download Neurotoxicology in Vitro Book in PDF, ePub and Kindle
Written by a distinguished panel of experts, students and researchers will find that this comprehensive and accessible volume provides a framework for the study of nerve cells ^in vitro^n for use in experimental neurotoxicology.
Author | : Louis W. Chang |
Publisher | : Elsevier |
Total Pages | : 875 |
Release | : 1995-04-20 |
Genre | : Science |
ISBN | : 0080537472 |
Download Neurotoxicology Book in PDF, ePub and Kindle
Neurotoxicology: Approaches and Methods provides a unique and comprehensive presentation of the current concepts and state-of-the-art methods for the assessment of neurotoxicity. The book analyzes various techniques available and discusses their strengths and weaknesses. This volume will serve as an excellent desk companion and laboratory guide for all investigators, researchers, clinicians, and students interested in neurotoxicology. The internationally knowngroup of editors divide the book into seven sections: Neuromorphological and Neuropathological Approaches; Neurophysiological Approaches; Neurobehavioral Toxicology; Neurochemical and Biomolecular Approaches; In-Vitro Models; Clinical Neurotoxicology; and Risk Assessment of Neurotoxicity. Each section yields the most up-to-date information by experts in their fields. Meticulously organized and edited, Neurotoxicology: Approaches and Methods is the most authoritative and well-planned neurotoxicology book on the market. Discusses neurobehavioral testing methods for assessment of neural dysfunctions Explains state-of-the-art diagnostic methods, such as clinico-neuropsychological and neurophysiological methods, for patients confronted by neurotoxic problems Discusses In Vitro methods, including aggregating brain cell methods, organotypic cultures, and the use of human neuronal cell lines for the assessment of neurotoxicity Presents step-by-step procedures for many methods Provides state-of-the-art neuromorphological and biomolecular methods and approaches for neurotoxicity investigation
Author | : Lucio G. Costa |
Publisher | : Humana Press |
Total Pages | : 415 |
Release | : 2011-08-09 |
Genre | : Medical |
ISBN | : 9781617791710 |
Download In Vitro Neurotoxicology Book in PDF, ePub and Kindle
In recent years, the need to develop acceptable alternatives to conventional animal testing for neurotoxicity and developmental neurotoxicity has been increasingly recognized, and much effort is being directed toward the development of alternative models, utilizing mostly mammalian cells in culture but also non-mammalian model systems. In Vitro Neurotoxicology: Methods and Protocols presents a series of cellular, biochemical, and molecular methodological protocols in the area of in vitro neurotoxicology, with an emphasis on mammalian cell culture systems. Opening with a section on methodologies for preparing several cellular systems of variable complexity, amenable for in vitro neurotoxicological studies, the thorough volume continues with coverage of methods to measure cellular death and major mechanisms, methods for assessing mechanisms of nervous system cell toxicity related to impairment of cell signaling, while a final section illustrates additional methods for assessing important nervous system processes such as cell proliferation, neuritogenesis, and synaptogenesis. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, In Vitro Neurotoxicology: Methods and Protocols serves researchers with an interest in assessing or characterizing the potential neurotoxicity of environmental contaminants, drugs, or other chemicals.
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 167 |
Release | : 1992-02-01 |
Genre | : Science |
ISBN | : 0309045312 |
Download Environmental Neurotoxicology Book in PDF, ePub and Kindle
Scientists agree that exposure to toxic agents in the environment can cause neurological and psychiatric illnesses ranging from headaches and depression to syndromes resembling parkinsonism. It can even result in death at high exposure levels. The emergence of subclinical neurotoxicity-the concept that long-term impairments can escape clinical detection-makes the need for risk assessment even more critical. This volume paves the way toward definitive solutions, presenting the current consensus on risk assessment and environmental toxicants and offering specific recommendations. The book covers: The biologic basis of neurotoxicity. Progress in the application of biologic markers. Reviews of a wide range of in vitro and in vivo testing techniques. The use of surveillance and epidemiology to identify neurotoxic hazards that escape premarket screening. Research needs. This volume will be an important resource for policymakers, health specialists, researchers, and students.
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 449 |
Release | : 1990-02-01 |
Genre | : Science |
ISBN | : 0309040477 |
Download Behavioral Measures of Neurotoxicity Book in PDF, ePub and Kindle
Exposure to toxic chemicalsâ€"in the workplace and at homeâ€"is increasing every day. Human behavior can be affected by such exposure and can give important clues that a person or population is in danger. If we can understand the mechanisms of these changes, we can develop better ways of testing for toxic chemical exposure and, most important, better prevention programs. This volume explores the emerging field of neurobehavioral toxicology and the potential of behavior studies as a noninvasive and economical means for risk assessment and monitoring. Pioneers in this field explore its promise for detecting environmental toxins, protecting us from exposure, and treating those who are exposed.
Author | : William Slikker Jr. |
Publisher | : Academic Press |
Total Pages | : 618 |
Release | : 2018-01-04 |
Genre | : Science |
ISBN | : 0128093943 |
Download Handbook of Developmental Neurotoxicology Book in PDF, ePub and Kindle
Handbook of Developmental Neurotoxicology, Second Edition, provides a comprehensive view of the fundamental aspects of neurodevelopment, the pathways and agents that affect them, relevant clinical syndromes, and risk assessment procedures for developmental neurotoxicants. The editors and chapter authors are internationally recognized experts whose collaboration heralds a remarkable advance in the field, bridging developmental neuroscience with the principles of neurotoxicology. The book features eight new chapters with newly recruited authors, making it an essential text for students and professionals in toxicology, neurotoxicology, developmental biology, pharmacology, and neuroscience. Presents a comprehensive, up-to-date resource on developmental neurotoxicology with updated chapters from the first edition Contains new chapters that focus on subjects recent to the field Includes well-illustrated material, with diagrams, charts, and tables Contains compelling case studies and chapters written by world experts
Author | : Matt Carter |
Publisher | : Academic Press |
Total Pages | : 416 |
Release | : 2022-03-26 |
Genre | : Medical |
ISBN | : 0323915612 |
Download Guide to Research Techniques in Neuroscience Book in PDF, ePub and Kindle
Modern neuroscience research is inherently multidisciplinary, with a wide variety of cutting edge new techniques to explore multiple levels of investigation. This Third Edition of Guide to Research Techniques in Neuroscience provides a comprehensive overview of classical and cutting edge methods including their utility, limitations, and how data are presented in the literature. This book can be used as an introduction to neuroscience techniques for anyone new to the field or as a reference for any neuroscientist while reading papers or attending talks. Nearly 200 updated full-color illustrations to clearly convey the theory and practice of neuroscience methods Expands on techniques from previous editions and covers many new techniques including in vivo calcium imaging, fiber photometry, RNA-Seq, brain spheroids, CRISPR-Cas9 genome editing, and more Clear, straightforward explanations of each technique for anyone new to the field A broad scope of methods, from noninvasive brain imaging in human subjects, to electrophysiology in animal models, to recombinant DNA technology in test tubes, to transfection of neurons in cell culture Detailed recommendations on where to find protocols and other resources for specific techniques "Walk-through" boxes that guide readers through experiments step-by-step
Author | : Harry Salem |
Publisher | : CRC Press |
Total Pages | : 616 |
Release | : 2003-03-26 |
Genre | : Medical |
ISBN | : 0203008790 |
Download Alternative Toxicological Methods Book in PDF, ePub and Kindle
Bringing together the recent and relevant contributions of over 125 scientists from industry, government, and academia in North America and Western Europe, Alternative Toxicological Methods explores the development and validation of replacement, reduction, and refinement alternatives (the 3Rs) to animal testing. Internationally recognized scientist
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 26 |
Release | : 2007-10-15 |
Genre | : |
ISBN | : 9264067396 |
Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 426: Developmental Neurotoxicity Study Book in PDF, ePub and Kindle
A developmental neurotoxicity study will provide information on the effects of repeated exposure to a substance during in utero and early postnatal development. The test substance is administered daily, generally orally, to mated females (rats are ...