Evolution Adjusted Tumor Pathophysiology PDF Download
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Author | : Albrecht Reichle |
Publisher | : Springer Science & Business Media |
Total Pages | : 438 |
Release | : 2013-07-01 |
Genre | : Medical |
ISBN | : 9400768664 |
Download Evolution-adjusted Tumor Pathophysiology: Book in PDF, ePub and Kindle
Combined modularized therapies for metastatic cancer are pointing to central problems of communication among ‘systems participators’. A communication theory explains 'social engineering', endogenously induced or by implementing non-normative boundary conditions. Evolution-adjusted tumor pathophysiology is borne by an evolution theory, which contrasts narrative evolution histories. The tool of rationalizations constituting the tumor's normativity (inflammation, immune response etc.) represents the non-genomic counterpart of the tumor genome and should be additionally assessed during tumor staging. Evolution-adjusted tumor pathophysiology allows implementing applied systems biology, a novel clinical and pharmaceutical technology for bioengineering tumor response and personalizing tumor therapy. Combined modularized therapy, evolution-adjusted tumor pathophysiology, and ‘universal’ biomarkers concertedly address genetically based tumor heterogeneity.
Author | : Charles Swanton |
Publisher | : Perspectives Cshl |
Total Pages | : 350 |
Release | : 2017 |
Genre | : Medical |
ISBN | : 9781621821434 |
Download Cancer Evolution Book in PDF, ePub and Kindle
Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. The contributors review efforts to characterize the subclonal architecture and dynamics of tumors, understand the roles of chromosomal instability, driver mutations, and mutation order, and determine how cancer cells respond to selective pressures imposed by anticancer agents, immune cells, and other components of the tumor microenvironment. They compare cancer evolution to organismal evolution and describe how ecological theories and mathematical models are being used to understand the complex dynamics between a tumor and its microenvironment during cancer progression. The authors also discuss improved methods to monitor tumor evolution (e.g., liquid biopsies) and the development of more effective strategies for managing and treating cancers (e.g., immunotherapies). This volume will therefore serve as a vital reference for all cancer biologists as well as anyone seeking to improve clinical outcomes for patients with cancer.
Author | : Walter Wahli |
Publisher | : MDPI |
Total Pages | : 583 |
Release | : 2019-01-09 |
Genre | : Biology (General) |
ISBN | : 3038974617 |
Download PPARs in Cellular and Whole Body Energy Metabolism Book in PDF, ePub and Kindle
This book is a printed edition of the Special Issue "PPARs in Cellular and Whole Body Energy Metabolism" that was published in IJMS
Author | : Richard Goldschmidt |
Publisher | : Yale University Press |
Total Pages | : 484 |
Release | : 1982-01-01 |
Genre | : Science |
ISBN | : 9780300028232 |
Download The Material Basis of Evolution Book in PDF, ePub and Kindle
An eminent geneticist examines the Darwinian theory of evolution, analyzes the hereditary differences that produce new species, and suggests changes in evolutionary theory based on his biological research
Author | : Richard Durrett |
Publisher | : Springer |
Total Pages | : 73 |
Release | : 2015-06-20 |
Genre | : Mathematics |
ISBN | : 3319160656 |
Download Branching Process Models of Cancer Book in PDF, ePub and Kindle
This volume develops results on continuous time branching processes and applies them to study rate of tumor growth, extending classic work on the Luria-Delbruck distribution. As a consequence, the author calculate the probability that mutations that confer resistance to treatment are present at detection and quantify the extent of tumor heterogeneity. As applications, the author evaluate ovarian cancer screening strategies and give rigorous proofs for results of Heano and Michor concerning tumor metastasis. These notes should be accessible to students who are familiar with Poisson processes and continuous time Markov chains. Richard Durrett is a mathematics professor at Duke University, USA. He is the author of 8 books, over 200 journal articles, and has supervised more than 40 Ph.D students. Most of his current research concerns the applications of probability to biology: ecology, genetics and most recently cancer.
Author | : Pengcheng Fu |
Publisher | : John Wiley & Sons |
Total Pages | : 672 |
Release | : 2009-08-13 |
Genre | : Technology & Engineering |
ISBN | : 9780470437971 |
Download Systems Biology and Synthetic Biology Book in PDF, ePub and Kindle
The genomic revolution has opened up systematic investigations and engineering designs for various life forms. Systems biology and synthetic biology are emerging as two complementary approaches, which embody the breakthrough in biology and invite application of engineering principles. Systems Biology and Synthetic Biology emphasizes the similarity between biology and engineering at the system level, which is important for applying systems and engineering theories to biology problems. This book demonstrates to students, researchers, and industry that systems biology relies on synthetic biology technologies to study biological systems, while synthetic biology depends on knowledge obtained from systems biology approaches.
Author | : Liang Cheng |
Publisher | : Springer |
Total Pages | : 1136 |
Release | : 2013-03-05 |
Genre | : Medical |
ISBN | : 9781461447993 |
Download Molecular Genetic Pathology Book in PDF, ePub and Kindle
Molecular Genetic Pathology, Second Edition presents up-to-date material containing fundamental information relevant to the clinical practice of molecular genetic pathology. Fully updated in each area and expanded to include identification of new infectious agents (H1N1), new diagnostic biomarkers and biomarkers for targeted cancer therapy. This edition is also expanded to include the many new technologies that have become available in the past few years such as microarray (AmpliChip) and high throughput deep sequencing, which will certainly change the clinical practice of molecular genetic pathology. Part I examines the clinical aspects of molecular biology and technology, genomics. Poharmacogenomics and proteomics, while Part II covers the clinically relevant information of medical genetics, hematology, transfusion medicine, oncology, and forensic pathology. Supplemented with many useful figures and presented in a helpful bullet-point format, Molecular Genetic Pathology, Second Edition provides a unique reference for practicing pathologists, oncologists, internists, and medical genetisists. Furthermore, a book with concise overview of the field and highlights of clinical applications will certainly help those trainees, including pathology residents, genetics residents, molecular pathology fellows, internists, hematology/oncology fellows, and medical technologists in preparing for their board examination/certification.
Author | : Andrew W. Bruce |
Publisher | : Springer Science & Business Media |
Total Pages | : 363 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 1447113985 |
Download Adenocarcinoma of the Prostate Book in PDF, ePub and Kindle
Carcinoma of the prostate increasingly dominates the attention of urologists for both scientific and clinical reasons. The search for an explanation and the prediction of the variable behaviour of the malignant prostatic cell continues unabated. The search for more precise tumour staging and more effective treatment is equally vigorous. Editors Andrew Bruce and John Trachtenberg have assembled acknowledged leaders in prostate cancer to present those areas of direct interest to the clinician. There are a number of other topics that might have been considered but most of these, such as experimental tumour models or biochemical factors affecting cell growth, still lack immediate application for the clinician. Carcinoma of the prostate continues to have its highest incidence in the western world, and the difference in comparison with the incidence in the Far East appears to be real and not masked by diagnostic or other factors. A number of other epidemiological aspects need careful analysis: Is the incidence increasing? Is the survival improving? Is the prognosis worse in the younger patient? Epidemiological data are easily misused and misinterpreted so that a precise analysis of the known facts makes an important opening chapter to this book.
Author | : Frans M.J. Debruyne |
Publisher | : Springer |
Total Pages | : 0 |
Release | : 1991-01-29 |
Genre | : Medical |
ISBN | : 9783540528357 |
Download Immunotherapy of Renal Cell Carcinoma Book in PDF, ePub and Kindle
With contributions by numerous experts
Author | : Shay Soker |
Publisher | : Humana Press |
Total Pages | : 225 |
Release | : 2017-10-20 |
Genre | : Medical |
ISBN | : 3319605119 |
Download Tumor Organoids Book in PDF, ePub and Kindle
Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.