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Evaluation of the Updated Site-Specific Risk Assessment for the National Bio- and Agro-Defense Facility in Manhattan, Kansas

Evaluation of the Updated Site-Specific Risk Assessment for the National Bio- and Agro-Defense Facility in Manhattan, Kansas
Author: National Research Council
Publisher: National Academies Press
Total Pages: 132
Release: 2012-09-24
Genre: Science
ISBN: 0309257824

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Safeguarding U.S. agriculture from foreign animal diseases and protecting our food system require cutting-edge research and diagnostic capabilities. The Department of Homeland Security (DHS) and the U.S. Department of Agriculture (USDA) have embarked on an important mission to replace the aging Plum Island Animal Disease Center (PIADC) with a new facility, the National Bio- and Agro-Defense Facility (NBAF). When operational, this new facility would be the world's fourth biosafety level-4 laboratory capable of large animal research. It would serve as a critical world reference laboratory for identifying emerging and unknown disease threats, and would thus be a critical asset in securing the future health, wealth, and security of the nation. DHS selected Manhattan, Kansas, as the site for the new NBAF after an extensive site-selection process that involved an environmental impact statement. The Government Accountability Office (GAO) raised concerns about DHS's analysis of the potential spread of foot-and-mouth disease virus (FMDv), one of the most serious foreign animal disease threats. Congress directed DHS to conduct a site-specific risk assessment (SSRA) for the NBAF, instructed the National Research Council (NRC) to independently evaluate the SSRA, and prohibited obligation of NBAF construction funds until the NRC review was complete. Congress mandated that DHS revise its SSRA to address shortcomings of the 2010 SSRA, directed the NRC to evaluate the updated SSRA (uSSRA), and again prohibited obligation of construction funds until the completion of the second review. The scope for both of these SSRA reports addressed accidental release of pathogens from the NBAF in Manhattan, Kansas and excluded terrorist acts and malicious threats from its risk assessments. Evaluation of the Updated Site-Specific Risk Assessment for the National Bio- and Agro-Defense Facility in Manhattan, Kansas is the evaluation of the final uSSRA.


Evaluation of a Site-Specific Risk Assessment for the Department of Homeland Security's Planned National Bio- and Agro-Defense Facility in Manhattan, Kansas

Evaluation of a Site-Specific Risk Assessment for the Department of Homeland Security's Planned National Bio- and Agro-Defense Facility in Manhattan, Kansas
Author: National Research Council
Publisher: National Academies Press
Total Pages: 146
Release: 2011-01-02
Genre: Science
ISBN: 0309162815

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Congress requested that the U.S. Department of Homeland Security (DHS) produce a site-specific biosafety and biosecurity risk assessment (SSRA) of the proposed National Bio- and Agro-Defense Facility (NBAF) in Manhattan, Kansas. The laboratory would study dangerous foreign animal diseases-including the highly contagious foot-and-mouth disease (FMD), which affects cattle, pigs, deer, and other cloven-hoofed animals-and diseases deadly to humans that can be transmitted between animals and people. Congress also asked the Research Council to review the validity and adequacy of the document. Until these studies are complete, Congress has withheld funds to build the NBAF. Upon review of the DHS assessment, the National Research Council found "several major shortcomings." Based on the DHS risk assessment, there is nearly a 70 percent chance over the 50-year lifetime of the facility that a release of FMD could result in an infection outside the laboratory, impacting the economy by estimates of $9 billion to $50 billion. The present Research Council report says the risks and costs of a pathogen being accidently released from the facility could be significantly higher. The committee found that the SSRA has many legitimate conclusions, but it was concerned that the assessment does not fully account for how a Biosafety-Level 3 Agriculture and Biosafety-Level 4 Pathogen facility would operate or how pathogens might be accidently released. In particular, the SSRA does not include important operation risks and mitigation issues, such as the risk associated with the daily cleaning of large animal rooms. It also fails to address risks that would likely increase the chances of an FMD leak or of the disease's spread after a leak, including the NBAF's close proximity to the Kansas State University College of Veterinary Medicine clinics and KSU football stadium or personnel moving among KSU facilities.


Evaluation of the Updated Site-specific Risk Assessment for the National Bio- and Agro-defense Facility in Manhattan, Kansas

Evaluation of the Updated Site-specific Risk Assessment for the National Bio- and Agro-defense Facility in Manhattan, Kansas
Author:
Publisher:
Total Pages: 111
Release: 2012
Genre:
ISBN:

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"Safeguarding U.S. agriculture from foreign animal diseases and protecting our food system require cutting-edge research and diagnostic capabilities. The Department of Homeland Security (DHS) and the U.S. Department of Agriculture (USDA) have embarked on an important mission to replace the aging Plum Island Animal Disease Center (PIADC) with a new facility, the National Bio- and Agro-Defense Facility (NBAF). When operational, this new facility would be the world's fourth biosafety level-4 laboratory capable of large animal research. It would serve as a critical world reference laboratory for identifying emerging and unknown disease threats, and would thus be a critical asset in securing the future health, wealth, and security of the nation. DHS selected Manhattan, Kansas, as the site for the new NBAF after an extensive site-selection process that involved an environmental impact statement. The Government Accountability Office (GAO) raised concerns about DHS's analysis of the potential spread of foot-and-mouth disease virus (FMDv), one of the most serious foreign animal disease threats. Congress directed DHS to conduct a site-specific risk assessment (SSRA) for the NBAF, instructed the National Research Council (NRC) to independently evaluate the SSRA, and prohibited obligation of NBAF construction funds until the NRC review was complete. Congress mandated that DHS revise its SSRA to address shortcomings of the 2010 SSRA, directed the NRC to evaluate the updated SSRA (uSSRA), and again prohibited obligation of construction funds until the completion of the second review. The scope for both of these SSRA reports addressed accidental release of pathogens from the NBAF in Manhattan, Kansas and excluded terrorist acts and malicious threats from its risk assessments. Evaluation of the Updated Site-Specific Risk Assessment for the National Bio- and Agro-Defense Facility in Manhattan, Kansas is the evaluation of the final uSSRA."--Résumé de l'éditeur.


Pandora's Gamble

Pandora's Gamble
Author: Alison Young
Publisher: Center Street
Total Pages: 348
Release: 2023-04-25
Genre: Political Science
ISBN: 1546002952

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Named to Kirkus Reviews’ Best Books of 2023 A ‘remarkable book.’ – The New York Times This fearless, deeply reported book about laboratory accidents asks the haunting question some elite scientists don’t want the public to entertain: Did the COVID-19 pandemic start with a lab leak in Wuhan, China? This is an obvious question. Yet there’s been an extraordinary effort by government officials in China, as well as leading scientific experts in the United States and around the world, to shut down any investigation or discussion of the lab leak theory. In private, however, some of the world’s elite scientists have seen a lab accident as a very real and horrifying possibility. They know what the public doesn’t. Lab accidents happen with shocking frequency. Even at the world’s best-run labs. That’s among the revelations from Alison Young, the award-winning investigative reporter who has spent nearly 15 years uncovering shocking safety breaches at prestigious U.S. laboratories for USA Today and other respected news outlets. In Pandora’s Gamble, Young goes deep into the troubling history -- and enormous risks -- of leaks and accidents at scientific labs. She takes readers on a riveting journey around the world to some of the worst lab mishaps in history, including the largely unknown stories of the lab workers at the U.S. Army’s Camp Detrick who suffered devastating infections at alarming rates during World War II. And her groundbreaking reporting exposes for the first time disturbing new details about recent accidents at prestigious laboratories – and the alarming gaps in government oversight that put all of us at risk. Sourced through meticulous reporting and exclusive interviews with key players including Dr. Anthony Fauci, former CDC Director Tom Frieden and others, Young’s examination reveals that the only thing rare about lab accidents is the public rarely finds out about them. Because when accidents happen, powerful people and institutions often work hard to keep the information secret.


Scientific Review of the Proposed Risk Assessment Bulletin from the Office of Management and Budget

Scientific Review of the Proposed Risk Assessment Bulletin from the Office of Management and Budget
Author: National Research Council
Publisher: National Academies Press
Total Pages: 302
Release: 2007-05-16
Genre: Political Science
ISBN: 0309104777

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Risk assessments are often used by the federal government to estimate the risk the public may face from such things as exposure to a chemical or the potential failure of an engineered structure, and they underlie many regulatory decisions. Last January, the White House Office of Management and Budget (OMB) issued a draft bulletin for all federal agencies, which included a new definition of risk assessment and proposed standards aimed at improving federal risk assessments. This National Research Council report, written at the request of OMB, evaluates the draft bulletin and supports its overall goals of improving the quality of risk assessments. However, the report concludes that the draft bulletin is "fundamentally flawed" from a scientific and technical standpoint and should be withdrawn. Problems include an overly broad definition of risk assessment in conflict with long-established concepts and practices, and an overly narrow definition of adverse health effects-one that considers only clinically apparent effects to be adverse, ignoring other biological changes that could lead to health effects. The report also criticizes the draft bulletin for focusing mainly on human health risk assessments while neglecting assessments of technology and engineered structures.


Department of Homeland Security Bioterrorism Risk Assessment

Department of Homeland Security Bioterrorism Risk Assessment
Author: Committee on Methodological Improvements to the Department of Homeland Security's Biological Agent Risk Analysis
Publisher:
Total Pages: 172
Release: 2008-12-03
Genre:
ISBN: 9780309384407

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The mission of Department of Homeland Security Bioterrorism Risk Assessment: A Call for Change, the book published in December 2008, is to independently and scientifically review the methodology that led to the 2006 Department of Homeland Security report, Bioterrorism Risk Assessment (BTRA) and provide a foundation for future updates. This book identifies a number of fundamental concerns with the BTRA of 2006, ranging from mathematical and statistical mistakes that have corrupted results, to unnecessarily complicated probability models and models with fidelity far exceeding existing data, to more basic questions about how terrorist behavior should be modeled. Rather than merely criticizing what was done in the BTRA of 2006, this new NRC book consults outside experts and collects a number of proposed alternatives that could improve DHS's ability to assess potential terrorist behavior as a key element of risk-informed decision making, and it explains these alternatives in the specific context of the BTRA and the bioterrorism threat.