ESSENTIALS OF ENDOMETRIAL PATHOLOGY
Author | : CHARLES GRAHAM. |
Publisher | : |
Total Pages | : |
Release | : |
Genre | : |
ISBN | : 9781684691265 |
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Author | : CHARLES GRAHAM. |
Publisher | : |
Total Pages | : |
Release | : |
Genre | : |
ISBN | : 9781684691265 |
Author | : Debra S Heller |
Publisher | : JP Medical Ltd |
Total Pages | : 172 |
Release | : 2012-04-23 |
Genre | : Medical |
ISBN | : 1907816100 |
Endometrial Pathology is a practical, clinically oriented reference on endometrial pathology. It is detailed enough for pathologists yet has a clinical focus that ensures its relevance and appeal to gynaecologists. The book covers the clinical aspects of evaluating the endometrium and the pathology of endometrial diseases, with differential diagnoses included as appropriate. There is a chapter on the histologic pitfalls in diagnosis and a final chapter on the latest information on molecular mechanisms and immunohistochemical tests.
Author | : John A. Maksem |
Publisher | : Springer Science & Business Media |
Total Pages | : 300 |
Release | : 2009-04-09 |
Genre | : Medical |
ISBN | : 0387899103 |
As compared with cytology’s use in other organ systems, direct cytological examination of the endometrium is not a widely practiced diagnostic procedure. This is an anomaly, because the endometrium is exceedingly available for cytological sampling, cytological sampling is comparably simple to perform, and, from the patient’s perspective, it is a gentle procedure as compared to other methods of specimen attainment. Over the years, as we personally gained more and more experience with specimen acquisition, processing and interpretation, we have come to look upon endometrial cytology as an effective method for ensuring endometrial normalcy and discovering and diagnosing malignant and premalignant states. In comparing endometrial cytology to endometrial biopsy, we have found that, in samples obtained by individuals experienced in specimen collection, cytology outperforms outpatient biopsy with regard to the patient’s tolerance of the procedure, adequacy of sampling among postmenopausal women, and detection of occult neoplasms. By devising a highly effective technical strategy to ensure the simultaneous creation of cell blocks and cytological samples from a single collection (that is detailed in the technical appendix of this work), we have moved endometrial brush collection into an arena of significance equaling—indeed exceeding—other methods of specimen collection and interpretation. Cytology, even in the absence of cell blocks, performs equally as well as biopsy in detecting outspoken hyperplasia or carcinoma. If nothing else, by reliably identifying benign, normal endometrial states, it serves to exclude more than 70% of women from unnecessary follow up testing with a high degree of confidence. Because brush sampling of the endometrium is limited to a depth of 1.5 to 2 mm, the method is not definitive for the detection of endometrial polyps, fibroids, stromal tumors, or tumors of the uterine wall musculature. However, endometrial cytology is useful for detecting benign estrogen-excess states such as disordered proliferation and various degrees of benign hyperplasia, for separating these states from frankly neoplastic states such as EIN and cancer, but not for subclassifying benign hyperplastic states in the absence of cell block preparations. When endometrial brushing with liquid fixation is used in conjunction with other techniques such as immunohistochemistry, concomitant biopsy or, more practically, hysteroscopy or sonohysterography, endometrial benignancy can be assured with a very high level of confidence (> 99%); indeed, manufacturing concomitant cell blocks of endometrial tissue fragments and using immunohistochemistry in selected cases significantly enhances the diagnostic specificity of the technique. In a woman with a patent cervix, endometrial brushing successfully collects material, even from late postmenopausal atrophic endometrium. It allows for the detection of serious diseases such as endometrial intraepithelial carcinoma under conditions where suction biopsy might miss or otherwise obviate the diagnosis. This work focuses on the background, collection technique, and reliability of endometrial cytology; it then overviews diagnostic criteria and diagnostic pitfalls encountered in the day-to-day practice of the art. Since endometrial cytology interpretation relies on intuiting tissue patterns from cytology preparations, a great deal of time is spent on cytohistological correlations and, where effective as part of a diagnostic strategy, on ancillary immunohistochemical staining. The discussion moves from normal states of the endometrium, through otherwise benign changes induced by an altered hormonal milieu or surface irritants, into neoplastic premalignant and malignant endometrial conditions. Finally, fixative and slide preparation techniques, that we deem as expeditious while serving to get the most information out of an endometrial cytology collection, are discussed in detail for the benefit of those who wish to recapitulate our work in their own practice.
Author | : Michael Mazur |
Publisher | : Springer Science & Business Media |
Total Pages | : 365 |
Release | : 2013-04-17 |
Genre | : Medical |
ISBN | : 1475739435 |
A logical approach to formulating a pathologic diagnosis from the diverse array of tissue received in the surgical pathology laboratory. The authors are both prominent gynaecologic pathologists, and this book is the result of their long-running Short Course presented at the International Academy of Pathology. Illustrations show typical artefacts and distortion and explain their impact on diagnostic interpretation, and each chapter includes a section on "Clinical Queries and Reporting" that summarises the features to be discussed in the final pathology report. Here is a strongly didactic approach to one of the most frequently ordered pathological examinations. You find superb illustrations on virtually every page and fast answers to everyday questions since emphasis is placed on clinically relevant material: commonly encountered specimens, common problems and common diagnostic issues.
Author | : Pranab Dey |
Publisher | : JP Medical Ltd |
Total Pages | : 324 |
Release | : 2017-02-06 |
Genre | : Fiction |
ISBN | : 9386261200 |
This book is a guide to gynaecological pathology with an emphasis on the diagnosis of common lesions. Beginning with an overview of epidemiology and developmental defects in the female genital tract, each of the following chapters examines a different type of tumour. The book focuses on both benign and malignant lesions, neoplastic and non-neoplastic lesions, as well as tumour-like conditions. Each condition is described in depth, covering aetiology, clinical features, macroscopy, histopathology, immunohistochemistry, molecular pathology, and treatment methods. The comprehensive text is enhanced by more than 700 clinical and pathological images, illustrations and tables. Key Points Comprehensive guide to gynaecological pathology with emphasis on common lesions Covers different types of tumour, both benign and malignant Discussed aetiology, clinical features, pathology and treatment methods Includes more than 700 clinical and pathological images, illustrations and tables
Author | : Oluwole Fadare |
Publisher | : Springer |
Total Pages | : 274 |
Release | : 2019-06-20 |
Genre | : Medical |
ISBN | : 3030179311 |
This Atlas of Uterine Pathology is comprehensive overview of the major pathologic processes that may be encountered in the uterine corpus and cervix. Each section is lavishly illustrated and covers normal histology as well as neoplastic and non-neoplastic diseases. Emphasis is placed on presenting the full morphologic and immunophenotypic spectrum of entities, including classical and variant pathology, in a manner that maximizes the utility of the information in routine diagnostic practice.
Author | : Michael T. Deavers |
Publisher | : Springer |
Total Pages | : 288 |
Release | : 2017-10-28 |
Genre | : Medical |
ISBN | : 3319579851 |
This text provides a comprehensive review for practicing pathologists to understand the molecular biology, diagnostics, and predictive markers and implications for therapy of uterine cancer. While molecular based therapeutic strategies for uterine cancer are not as well developed as for some other organ sites, these are the most common gynecologic malignancies and there have been many important recent developments that are discussed in this volume. Comprehensive chapters address essential information about endometrial carcinoma, uterine mesenchymal tumors, and cervical carcinoma and include the pathogenesis of carcinoma and discuss molecular based classification, biomarkers, therapy, prevention, and hereditary cancers of the uterus. Precision Molecular Pathology of Uterine Cancer is a unique and one of a kind resource for practicing pathologists, pathologists in training and gynecologists.
Author | : Yee Khong |
Publisher | : CRC Press |
Total Pages | : 324 |
Release | : 2005-11-16 |
Genre | : Medical |
ISBN | : 9781841843674 |
This bench book provides a clinically pragmatic and diagnostically up-to-date basis for the pathological examination of the endometrium, one of the most commonly examined tissues in anatomical pathology. The literature is summarized succinctly, histopathological concepts and details are presented in an accessible manner and controversial or unproven concepts are highlighted. A major emphasis of the book is the way out of the differential diagnosis in those lesions that cause much difficulty. Clinical correlates are also stressed to make this a clinically practical book.
Author | : Lora Hedrick Ellenson |
Publisher | : Springer |
Total Pages | : 284 |
Release | : 2016-12-01 |
Genre | : Medical |
ISBN | : 3319431390 |
This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is a meant to serve as a resource for a wide range of scientists, from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma.
Author | : Ancel Blaustein |
Publisher | : Springer Science & Business Media |
Total Pages | : 1261 |
Release | : 2011-01-10 |
Genre | : Medical |
ISBN | : 1441904883 |
New edition includes more than 350 new illustrations and 22 revised chapters Written by internationally recognized experts Each entry is structured the same way, from general to more specific information, which allows the reader to quickly access key information in every chapter Since the publication of the 1/e in 1977, Blaustein's Pathology of the Female Genital Tract has consolidated its position as the leading textbook of gynecological pathology. an essential reference for all pathologists and residents, this thoroughly updated Sixth Edition includes more than 1500 illustrations in color, i