Equilibria And Kinetics Of Biological Macromolecules PDF Download

Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Equilibria And Kinetics Of Biological Macromolecules PDF full book. Access full book title Equilibria And Kinetics Of Biological Macromolecules.

Equilibria and Kinetics of Biological Macromolecules

Equilibria and Kinetics of Biological Macromolecules
Author: Prof. Jan Hermans
Publisher: John Wiley & Sons
Total Pages: 411
Release: 2013-10-22
Genre: Science
ISBN: 1118733770
GET BOOK

Download Equilibria and Kinetics of Biological Macromolecules Book in PDF, ePub and Kindle

Progressively builds a deep understanding of macromolecular behavior Based on each of the authors' roughly forty years of biophysics research and teaching experience, this text instills readers with a deep understanding of the biophysics of macromolecules. It sets a solid foundation in the basics by beginning with core physical concepts such as thermodynamics, quantum chemical models, molecular structure and interactions, and water and the hydrophobic effect. Next, the book examines statistical mechanics, protein-ligand binding, and conformational stability. Finally, the authors address kinetics and equilibria, exploring underlying theory, protein folding, and stochastic models. With its strong emphasis on molecular interactions, Equilibria and Kinetics of Biological Macromolecules offers new insights and perspectives on proteins and other macromolecules. The text features coverage of: Basic theory, applications, and new research findings Related topics in thermodynamics, quantum mechanics, statistical mechanics, and molecular simulations Principles and applications of molecular simulations in a dedicated chapter and interspersed throughout the text Macromolecular binding equilibria from the perspective of statistical mechanics Stochastic processes related to macromolecules Suggested readings at the end of each chapter include original research papers, reviews and monographs, enabling readers to explore individual topics in greater depth. At the end of the text, ten appendices offer refreshers on mathematical treatments, including probability, computational methods, Poisson equations, and defining molecular boundaries. With its classroom-tested pedagogical approach, Equilibria and Kinetics of Biological Macromolecules is recommended as a graduate-level textbook for biophysics courses and as a reference for researchers who want to strengthen their understanding of macromolecular behavior.

Biomolecular Kinetics

Biomolecular Kinetics
Author: Clive R. Bagshaw
Publisher: CRC Press
Total Pages: 446
Release: 2017-10-04
Genre: Medical
ISBN: 1498727247
GET BOOK

Download Biomolecular Kinetics Book in PDF, ePub and Kindle

"a gem of a textbook which manages to produce a genuinely fresh, concise yet comprehensive guide" –Mark Leake, University of York "destined to become a standard reference.... Not just a ‘how to’ handbook but also an accessible primer in the essentials of kinetic theory and practice." –Michael Geeves, University of Kent "covers the entire spectrum of approaches, from the traditional steady state methods to a thorough account of transient kinetics and rapid reaction techniques, and then on to the new single molecule techniques" –Stephen Halford, University of Bristol This illustrated treatment explains the methods used for measuring how much a reaction gets speeded up, as well as the framework for solving problems such as ligand binding and macromolecular folding, using the step-by-step approach of numerical integration. It is a thoroughly modern text, reflecting the recent ability to observe reactions at the single-molecule level, as well as advances in microfluidics which have given rise to femtoscale studies. Kinetics is more important now than ever, and this book is a vibrant and approachable entry for anyone who wants to understand mechanism using transient or single molecule kinetics without getting bogged down in advanced mathematics. Clive R. Bagshaw is Emeritus Professor at the University of Leicester, U.K., and Research Associate at the University of California at Santa Cruz, U.S.A.

Binding and Linkage

Binding and Linkage
Author: Jeffries Wyman
Publisher: University Science Books
Total Pages: 358
Release: 1990
Genre: Science
ISBN: 9780935702569
GET BOOK

Download Binding and Linkage Book in PDF, ePub and Kindle

Ligand-macromolecule interactions are of fundamental importance in the control of biological processes. This book applies the principles of linkage thermodynamics to polyfunctional macromolecular systems under equilibrium conditions, and describes the binding, linkage, and feedback phenomena that lead to control of complex metabolic processes. The first chapter sets out the different processes (conformational changes, changes in state of aggregation, phase changes) involving biological macromolecules which are affected by chemical variables (such as ligands) or physical variables (such as temperature and pressure). The general effects of ligands on micromolecular conformations and interactions are illustrated with specific examples from the respiratory proteins, electron-transport proteins, and nucleic acid binding proteins. Subsequent chapters develop these themes, and describe in detail how the mathematics of regulation and control can be applied to macromolecules in biological system.

Energetics of Biological Macromolecules, Part D

Energetics of Biological Macromolecules, Part D
Author: Jo M. Holt
Publisher: Elsevier
Total Pages: 315
Release: 2004-04-02
Genre: Science
ISBN: 0080497179
GET BOOK

Download Energetics of Biological Macromolecules, Part D Book in PDF, ePub and Kindle

This volume focuses on the cooperative binding aspects of energetics in biological macromolecules. Methodologies such as NMR, small-angle scattering techniques for analysis, calorimetric analysis, fluorescence quenching, and time resolved FRET measurements are discussed. *Methods for Evaluating Cooperativity in a Dimeric Hemoglobin*Multiple-Binding of Ligands to a Linear Biopolymer*Fluorescence Quenching Methods to Study Protein-Nucleic Acid Interactions*Linked Equilibria in Biotin Repressor Function: Thermodynamic, Structural and Kinetic Analysis

Binding and Kinetics for Molecular Biologists

Binding and Kinetics for Molecular Biologists
Author: James Andrew Goodrich
Publisher: CSHL Press
Total Pages: 188
Release: 2007
Genre: Carrier proteins
ISBN: 0879697369
GET BOOK

Download Binding and Kinetics for Molecular Biologists Book in PDF, ePub and Kindle

This handbook offers a practical guide to the principles of quantitative analysis in biological experiments. The material is primarily aimed at working molecular biologists, but the scope and clarity of presentation make it equally suitable as an introduction for students. Topics covered range from the basics — such as measuring the concentrations of macromolecules — through considerations of binding constants and the kinetics of molecular interactions. The book ends with a thorough consideration of data analysis.

Introduction to Macromolecular Binding Equilibria

Introduction to Macromolecular Binding Equilibria
Author: Charles P. Woodbury
Publisher: CRC Press
Total Pages: 272
Release: 2007-11-08
Genre: Science
ISBN: 1420052993
GET BOOK

Download Introduction to Macromolecular Binding Equilibria Book in PDF, ePub and Kindle

Macromolecules in the body form noncovalent associations, such as DNA-protein or protein-protein complexes, that control and regulate numerous cellular functions. Understanding how changes in the concentration and conformation of these macromolecules can trigger physiological responses is essential for researchers developing drug therapies to treat

Biomolecular Kinetics

Biomolecular Kinetics
Author: Clive Richard Bagshaw
Publisher: CRC Press
Total Pages: 0
Release: 2017
Genre: Biochemistry
ISBN: 9781138066588
GET BOOK

Download Biomolecular Kinetics Book in PDF, ePub and Kindle

Kinetic theory -- Some underlying physical principles -- Enzyme kinetics -- Beyond enzyme kinetics -- Experimental strategies -- Instrumentation -- Data analysis -- Single-molecule kinetics -- Kinetic thinking : back to the future

Thermodynamics and Kinetics for the Biological Sciences

Thermodynamics and Kinetics for the Biological Sciences
Author: Gordon G. Hammes
Publisher: Wiley-Interscience
Total Pages: 192
Release: 2000-06-26
Genre: Science
ISBN:
GET BOOK

Download Thermodynamics and Kinetics for the Biological Sciences Book in PDF, ePub and Kindle

Gain a working knowledge of thermodynamics and kinetics with a minimum of mathematics-a guide for individuals in the biological sciences An understanding of thermodynamics and kinetics is essential for researchers investigating molecular phenomena in diverse disciplines, including bioorganic chemistry, medicinal chemistry, biochemistry, pharmaceuticals, and biology. The use of these physical chemistry tools in the biological sciences has exploded over the past fifteen years, but the majority of works on thermodynamics and kinetics require mathematical expertise beyond that of many researchers in the field. Presenting a highly accessible introduction to thermodynamics and kinetics, Thermodynamics and Kinetics for the Biological Sciences employs a minimum of mathematics, assuming only a basic calculus background, while treating a wide range of topics in a logical and easy-to-follow style. All principles and concepts are clearly illustrated through the use of relevant applications and examples from the biological sciences, and explanations are further enhanced with problems and up-to-date references. Written by a world-renowned authority on biochemical kinetics, this remarkable book also features an easy-to-understand statistical development of entropy and a more extensive coverage of chemical kinetics and ligand binding to macromolecules than is usually found in books of this kind. Readers will acquire a working knowledge of thermodynamics and kinetics that they can readily apply to biological systems and use for exploring the scientific literature.

Essentials of Chemical Biology

Essentials of Chemical Biology
Author: Andrew D. Miller
Publisher: John Wiley & Sons
Total Pages: 620
Release: 2013-05-03
Genre: Science
ISBN: 1118687833
GET BOOK

Download Essentials of Chemical Biology Book in PDF, ePub and Kindle

"This excellent work fills the need for an upper-level graduate course resource that examines the latest biochemical, biophysical, and molecular biological methods for analyzing the structures and physical properties of biomolecules... This reviewer showed [the book] to several of his senior graduate students, and they unanimously gave the book rave reviews. Summing Up: Highly recommended..." CHOICE Chemical biology is a rapidly developing branch of chemistry, which sets out to understand the way biology works at the molecular level. Fundamental to chemical biology is a detailed understanding of the syntheses, structures and behaviours of biological macromolecules and macromolecular lipid assemblies that together represent the primary constituents of all cells and all organisms. The subject area of chemical biology bridges many different disciplines and is fast becoming an integral part of academic and commercial research. This textbook is designed specifically as a key teaching resource for chemical biology that is intended to build on foundations lain down by introductory physical and organic chemistry courses. This book is an invaluable text for advanced undergraduates taking biological, bioorganic, organic and structural chemistry courses. It is also of interest to biochemists and molecular biologists, as well as professionals within the medical and pharmaceutical industry. Key Features: A comprehensive introduction to this dynamic area of chemistry, which will equip chemists for the task of understanding and studying the underlying principles behind the functioning of biological macro molecules, macromolecular lipid assemblies and cells. Covers many basic concepts and ideas associated with the study of the interface between chemistry and biology. Includes pedagogical features such as: key examples, glossary of equations, further reading and links to websites. Clearly written and richly illustrated in full colour.