Epitranscriptomics PDF Download
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Author | : Stefan Jurga |
Publisher | : Springer Nature |
Total Pages | : 632 |
Release | : 2021-07-28 |
Genre | : Science |
ISBN | : 3030716120 |
Download Epitranscriptomics Book in PDF, ePub and Kindle
This book reviews a novel and exciting field of cellular and molecular biology called epitranscriptomics, which focuses on changes in an organism’s cells resulting from the posttranscriptional modification of cellular RNA. RNA-binding proteins (RBPs) play a crucial role in these posttranscriptional modifications and also support several cellular processes necessary for maintaining RNA homeostasis. Exploring the mechanisms underlying RNA modifications and RBP function is an emerging area of biomedical research, taking the study of gene regulation a step beyond epigenetics. This book reveals that the RNA molecule is not just an information-carrying molecule with some secondary structures. Accordingly, how RNA is modified, regulated, packaged, and controlled is an important aspect. Leading experts address questions such as where the over 170 distinct posttranscriptional RNA modifications are located on the genome, what percentage of mRNAs and noncoding RNAs these modifications include, and how an RNA modification impacts a person’s biology. In closing, the book reviews the role of RNA modifications and RBPs in a variety of diseases and their pathogenesis. Addressing some of the most exciting challenges in epitranscriptomics, this book provides a valuable and engaging resource for researchers in academia and industry studying the phenomena of RNA modification.
Author | : Giovanni Nigita |
Publisher | : Frontiers Media SA |
Total Pages | : 127 |
Release | : 2019-01-31 |
Genre | : |
ISBN | : 2889457419 |
Download Epitranscriptomics: The Novel RNA Frontier Book in PDF, ePub and Kindle
Following the formulation of the central dogma of molecular biology and the later discovery of classes of non-coding RNAs, the primary focus of Genetics was essentially on variation of DNA aiming at elucidating biological pathways perturbed in diseases. Recently, extensive attention has shifted towards the study of posttranscriptional RNA modifications occurring in both protein-coding as well as non-coding RNAs, revealing a novel and finer layer of complexity in gene regulation. This, in turn, has led to the birth of the novel field of ‘Epitranscriptomics’. The recent increase of applications of high-throughput sequencing technology (HTS) has allowed the unprecedented opportunity to identify on a transcriptome-wide scale, millions of RNA modifications in human genes, counting today more than 140 distinct types such as: methylation (e.g. m6A, m1A, m5C, hm5C, 2’OMe) methylation (e.g. m6A, m1A, m5C, hm5C, 2’OMe), pseudourylation (?), deamination (e.g. A-to-I RNA editing). The scope of this Research Topic was to collect both reviews and research articles addressing the wet lab approaches and bioinformatics methodologies necessary to aid in the identification of novel RNA modifications and characterization of their biological functions. Among the articles embracing the aim of the Research Topic, we have collected four original research and methods articles, five reviews, and a technology article.
Author | : Xiao Han |
Publisher | : Frontiers Media SA |
Total Pages | : 387 |
Release | : 2022-05-05 |
Genre | : Science |
ISBN | : 2889761061 |
Download RNA Modifications and Epitranscriptomics Book in PDF, ePub and Kindle
Author | : Mattia Pelizzola |
Publisher | : Frontiers Media SA |
Total Pages | : 155 |
Release | : 2021-02-02 |
Genre | : Science |
ISBN | : 2889664406 |
Download Computational Epitranscriptomics: Bioinformatic Approaches for the Analysis of RNA Modifications Book in PDF, ePub and Kindle
Author | : Pedro H. Oliveira |
Publisher | : Springer Nature |
Total Pages | : 267 |
Release | : 2023-02-01 |
Genre | : Science |
ISBN | : 107162962X |
Download Computational Epigenomics and Epitranscriptomics Book in PDF, ePub and Kindle
This volume details state-of-the-art computational methods designed to manage, analyze, and generally leverage epigenomic and epitranscriptomic data. Chapters guide readers through fine-mapping and quantification of modifications, visual analytics, imputation methods, supervised analysis, and integrative approaches for single-cell data. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Computational Epigenomics and Epitranscriptomics aims to provide an overview of epiomic protocols, making it easier for researchers to extract impactful biological insight from their data.
Author | : Giovanni Nigita |
Publisher | : Frontiers Media SA |
Total Pages | : 208 |
Release | : 2023-06-30 |
Genre | : Science |
ISBN | : 2832527779 |
Download RNA modifications and epitranscriptomics - volume II Book in PDF, ePub and Kindle
Author | : Narendra Wajapeyee |
Publisher | : |
Total Pages | : 298 |
Release | : 2018 |
Genre | : Transcription factors |
ISBN | : 9781493988082 |
Download Epitranscriptomics Book in PDF, ePub and Kindle
Author | : |
Publisher | : Academic Press |
Total Pages | : 320 |
Release | : 2020-08-07 |
Genre | : Medical |
ISBN | : 0128140860 |
Download Stem Cell Epigenetics Book in PDF, ePub and Kindle
Growing evidence suggests that epigenetic mechanisms play a central role in stem cell biology and are vital for determining gene expression during cellular differentiation and governing mammalian development. In Stem Cell Epigenetics, leading international researchers examine how chromatin regulation and bona fide epigenetic mechanisms underlie stem cell renewal and differentiation. Authors also explore how the diversity of cell types, including the extent revealed by single cell omic approaches, is achieved, and how such processes may be reversed or managed via epigenetic reprogramming. Topics discussed include chromatin in pluripotency, stem cells and DNA methylation, histone modifications in stem cells and differentiation, higher-order chromatin conformation in pluripotent cells, stem cells and cancer, epigenetics and disease modeling, brain organoids from pluripotent cells, transcriptional regulation in stem cells and differentiation, non-coding RNAs in pluripotency and early differentiation, and diseases caused by epigenetic alterations in stem cells. Additionally, the book discusses the potential implementation of stem cell epigenetics in drug discovery, regenerative medicine, and disease treatment. Stem Cell Epigenetics will provide researchers and physicians with a state-of-the-art map to orient across the frontiers of this fast-evolving field. Analyzes the role of epigenetics in embryonic stem cell regulation Indicates the epigenetic mechanisms involved in stem cell differentiation and highlights modifications and misregulations that may result in disease pathogenesis Examines the potential applications of stem cell epigenetics in therapeutic disease interventions and regenerative medicine, providing a foundation for researchers and physicians to bring this exciting and fast-evolving field into a clinical setting Features chapter contributions by leading international experts
Author | : Enrico Mihich |
Publisher | : Springer Science & Business Media |
Total Pages | : 251 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 1461519276 |
Download Normal and Malignant Hematopoiesis Book in PDF, ePub and Kindle
''An exciting glance at key issues in contemporary hematopoiesis.'' -The Quarterly Review of Biology
Author | : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans |
Publisher | : IARC |
Total Pages | : 540 |
Release | : 2004 |
Genre | : Medical |
ISBN | : 9789283212843 |
Download Some Drinking-water Disinfectants and Contaminants, Including Arsenic Book in PDF, ePub and Kindle
A working group of 23 experts from 13 countries met in Lyon to evaluate the evidence for carcinogenicity of arsenic (mostly naturally occurring) as a contaminant of drinking-water, and of the water-disinfectant chloramine. The working group also evaluated or re-evaluated four chlorination by-products found in drinking-water, namely chloral hydrate, di- and trichloroacetic acids, and 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (also known as MX). High-level exposure to arsenic in drinking-water occurs in some regions such as China, Latin America, Bangladesh and West Bengal. The Working Group reviewed epidemiological studies of human cancer (mainly ecological studies in Taiwan and Chile, and several case-control and cohort studies) in relation to arsenic in drinking-water. Arsenic in drinking-water (primarily inorganic, as arsenate and to a lesser extent arsenite) was evaluated as carcinogenic to humans (Group 1) on the basis of sufficient evidence for an increased risk for cancer of the urinary bladder, lung and skin. Studies on inorganic arsenic in experimental animals provided limited evidence for its carcinogenicity, but sufficient evidence was found in experimental animals for the carcinogenicity of dimethylarsinic acid (an organic form of arsenic), which produced urinary bladder tumours in rats and lung tumours in mice after oral administration.