Enzyme and Metabolic Inhibitors
Author | : J. Leyden Webb |
Publisher | : |
Total Pages | : 949 |
Release | : 1963 |
Genre | : Enzyme inhibitors |
ISBN | : |
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Author | : J. Leyden Webb |
Publisher | : |
Total Pages | : 949 |
Release | : 1963 |
Genre | : Enzyme inhibitors |
ISBN | : |
Author | : John Leyden Webb |
Publisher | : |
Total Pages | : 949 |
Release | : 1965 |
Genre | : |
ISBN | : |
Author | : J. Leyden Webb |
Publisher | : |
Total Pages | : |
Release | : 1965 |
Genre | : |
ISBN | : |
Author | : John Leyden Webb |
Publisher | : |
Total Pages | : 984 |
Release | : 1963 |
Genre | : |
ISBN | : |
Author | : J. Leyden Webb |
Publisher | : |
Total Pages | : 949 |
Release | : 1963 |
Genre | : |
ISBN | : |
Author | : R Hochster |
Publisher | : Elsevier |
Total Pages | : 690 |
Release | : 2012-12-02 |
Genre | : Science |
ISBN | : 0323143385 |
Metabolic Inhibitors: A Comprehensive Treatise, Volume I focuses on the properties of inhibitors of metabolic processes or enzyme systems. The book explores a wide range of substances that interfere with (and usually retard) metabolic and enzymic processes, emphasizing the inhibitor rather than the metabolic or enzymic system that is affected. Organized into 15 chapters, this volume begins with a historical overview of research on the mode of action of biological inhibitors, touching on the principle of competitive inhibition by structural analogues. The book then turns to the concept of a competitive enzymic relationship by growth inhibitory analogues and their corresponding amino acids; the metabolic inhibitory effects of polypeptides and proteins; and the use of pentoses as analogues in carbohydrate metabolism. The reader is also introduced to the metabolic inhibitory effects of fatty acids; the intermediary metabolism of phospholipids; and the inhibition of purine and pyrimidine analogues. The remaining chapters discuss the role of nucleic acids and nucleoproteins in the regulation of cellular metabolism and the inhibition of amino acid decarboxylases, cholesterol, and steroid biosynthesis. This book will be of value to biochemists, advanced students, medical research workers, and research workers in the various fields of biological chemistry, as well as those working in the microbiological, botanical, and other agricultural fields.
Author | : R. M. Hochster |
Publisher | : |
Total Pages | : 702 |
Release | : 1963 |
Genre | : Antimetabolites |
ISBN | : |
There seems to be little doubt, when the general field of metabolic inhibition is contemplated, that the role of metabolic inhibitors in the direct control of disease is undergoing serious assessment at the present time. The manner in whitch inhibitors act, a firm knowledge of the underlying principles concerning their activities, will provide the means in the future for the development of drugs with greater potency and specieficity. The recognition of the importance of feedback mechanisms, whereby products of enzymic reactions the rates of their own synthesis, or of cases where a metabolite of one enzymic reaction sequence is also a competitive inhibitor od another, separete but related, sequence is an important step forward our understanding of cellular reaction processees. An appreciation of the properties of methabolic inhibitors drawn from a great variety of enzyme studies is vital for work which is expected to lead to further understanding of abnormal cell growth, for the development of antitumor agents, for obtaining knowledge of genetic relationships to disease conditions, and for the exploration of processes as distinct from static metabolic states. A relatively new field in the realms of biochemistry and physiology is energing from the recent work on trasport carriers across cell membrannes. Here again, a knowledge of the effects of structural analogues and other types of metabolic inhibitors on the specific processes governing the activity of such carriers is of paramount importance in the development of experimental approaches to problems of this type. This field promisses to be as crucial in future work on the control of cell behavior as knowledge of specific inhibitory phenomena of isolated enzyme systems has been in bringing us to the present stage of understanding.
Author | : J. Leyden Webb |
Publisher | : |
Total Pages | : 949 |
Release | : 1963 |
Genre | : |
ISBN | : |
Author | : John Leyden Webb |
Publisher | : |
Total Pages | : 986 |
Release | : 1963 |
Genre | : Antimetabolites |
ISBN | : |
Author | : Shiew-Mei Huang |
Publisher | : Academic Press |
Total Pages | : 764 |
Release | : 2021-10-16 |
Genre | : Medical |
ISBN | : 0128198842 |
Atkinson’s Principles of Clinical Pharmacology, Fourth Edition is the essential reference on the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This well-regarded survey continues to focus on the basics of clinical pharmacology for the development, evaluation and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the fourth edition has been thoroughly updated to provide readers with an ideal reference on the wide range of important topics impacting clinical pharmacology. Presents the essential knowledge for effective practice of clinical pharmacology Includes a new chapter and extended discussion on the role of personalized and precision medicine in clinical pharmacology Offers an extensive regulatory section that addresses US and international issues and guidelines Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers, along with further discussion on "Phase 0" studies (microdosing) and PBPK