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Enzyme and Metabolic Inhibitors

Enzyme and Metabolic Inhibitors
Author: John Leyden Webb
Publisher:
Total Pages: 1272
Release: 1966
Genre: Antimetabolites
ISBN:

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Metabolic Inhibitors V2

Metabolic Inhibitors V2
Author: R Hochster
Publisher: Elsevier
Total Pages: 772
Release: 2012-12-02
Genre: Science
ISBN: 0323142605

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Metabolic Inhibitors: A Comprehensive Treatise, Volume II charts the major advances that have been made in understanding metabolic inhibition and inhibitors. The book explores the inhibition of enzymes, such as catechol amines, acetylcholinesterases, and succinic dehydrogenases, as well as inhibitors of processes ranging from gas transport to photosynthesis, nitrogen fixation, nitrification, and oxidative phosphorylation. Organized into 23 chapters, this volume begins with a discussion on the biosynthesis of nicotinamide adenine dinucleotide and dinucleotide analogues. The reader is then introduced to the biochemical significance and mode of action of antibiotics; substances interfering with the biogenesis and metabolism of catechol amines; and inhibition of enzyme activities by thioarsenites. Some chapters focus on mercaptide-forming agents, biological alkylating agents, organophosphates, and carbamates, while others examine the metabolic inhibitory effects of quinones, fungicides, and surface active agents. The book also considers the effects of anesthetics, depressants, and tranquilizers on cerebral metabolism, and then concludes with a chapter on inhibition caused by radiation. This book is a valuable resource for biochemists, advanced students, medical research workers, and research workers in the fields of biological chemistry, microbiology, botany, and agriculture.


Enzyme and Metabolic Inhibitors

Enzyme and Metabolic Inhibitors
Author: J. Leyden Webb
Publisher:
Total Pages: 950
Release: 1963
Genre: Enzyme inhibitors
ISBN:

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Metabolic Inhibitors V3

Metabolic Inhibitors V3
Author: R Hochster
Publisher: Elsevier
Total Pages: 526
Release: 2012-12-02
Genre: Science
ISBN: 0323147151

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Metabolic Inhibitors: A Comprehensive Treatise, Volume III reviews developments in metabolic and enzyme inhibition. With contributions by investigators experienced in their respective fields, the book explores metabolic processes or systems and covers topics ranging from membrane transport to immunization; gene activity; DNA, RNA, and protein syntheses; photosynthesis; lipid metabolism; and blood clotting. Organized into 12 chapters, this volume begins with an overview of transport reactions and their inhibition, emphasizing inhibitors of ATPase including cations, substrates, and products. Some chapters deal with inhibitors, such as antibiotics; polypeptide and protein hormones; modified transfer RNAs; and oligonucleotides. Other chapters discuss inhibitors of immune reactions; animal virus replication; plant viruses and mycoplasma; and isozymes. An account of genetic deletions is also given. Finally, the book considers molecules that act as repressors and derepressors of gene activity. This book will be beneficial to biochemists and medical research workers, as well as to virologists, microbiologists, plant physiologists, and agronomists.


Metabolic Inhibitors V1

Metabolic Inhibitors V1
Author: R Hochster
Publisher: Elsevier
Total Pages: 690
Release: 2012-12-02
Genre: Science
ISBN: 0323143385

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Metabolic Inhibitors: A Comprehensive Treatise, Volume I focuses on the properties of inhibitors of metabolic processes or enzyme systems. The book explores a wide range of substances that interfere with (and usually retard) metabolic and enzymic processes, emphasizing the inhibitor rather than the metabolic or enzymic system that is affected. Organized into 15 chapters, this volume begins with a historical overview of research on the mode of action of biological inhibitors, touching on the principle of competitive inhibition by structural analogues. The book then turns to the concept of a competitive enzymic relationship by growth inhibitory analogues and their corresponding amino acids; the metabolic inhibitory effects of polypeptides and proteins; and the use of pentoses as analogues in carbohydrate metabolism. The reader is also introduced to the metabolic inhibitory effects of fatty acids; the intermediary metabolism of phospholipids; and the inhibition of purine and pyrimidine analogues. The remaining chapters discuss the role of nucleic acids and nucleoproteins in the regulation of cellular metabolism and the inhibition of amino acid decarboxylases, cholesterol, and steroid biosynthesis. This book will be of value to biochemists, advanced students, medical research workers, and research workers in the various fields of biological chemistry, as well as those working in the microbiological, botanical, and other agricultural fields.


Enzyme Inhibitors and Activators

Enzyme Inhibitors and Activators
Author: Murat Şentürk
Publisher: BoD – Books on Demand
Total Pages: 270
Release: 2017-03-29
Genre: Science
ISBN: 9535130579

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Over the recent years, medicinal chemistry has become responsible for explaining interactions of chemical molecule processes such that many scientists in the life sciences from agronomy to medicine are engaged in medicinal research. This book contains an overview focusing on the research area of enzyme inhibitor and activator, enzyme-catalyzed biotransformation, usage of microbial enzymes, enzymes associated with programmed cell death, natural products as potential enzyme inhibitors, protease inhibitors from plants in insect pest management, peptidases, and renin-angiotensin system. The book provides an overview on basic issues and some of the recent developments in medicinal science and technology. Especially, emphasis is devoted to both experimental and theoretical aspect of modern medicine. The primary target audience for the book includes students, researchers, chemists, molecular biologists, medical doctors, pharmacologists, and professionals who are interested in associated areas. The textbook is written by international scientists with expertise in biochemistry, enzymology, molecular biology, and genetics, many of which are active in biochemical and pharmacological research. I would like to acknowledge the authors for their contribution to the book. We hope that the textbook will enhance the knowledge of scientists in the complexities of some medical approaches; it will stimulate both professionals and students to dedicate part of their future research in understanding relevant mechanisms and applications of pharmacology.