Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Elucidating The Mechanism Of Action Of Orotidine Monophosphate Decarboxylase Odcase Using Isotope Labeling Enzyme Kinetics And 6 Cn Ump Inhibitor PDF full book. Access full book title Elucidating The Mechanism Of Action Of Orotidine Monophosphate Decarboxylase Odcase Using Isotope Labeling Enzyme Kinetics And 6 Cn Ump Inhibitor.
| Author | : Wickliffe O. Wepukhulu |
| Publisher | : |
| Total Pages | : 136 |
| Release | : 2006 |
| Genre | : Decarboxylases |
| ISBN | : |
| Author | : Jeehiun K. Lee |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 172 |
| Release | : 2004-06-25 |
| Genre | : Science |
| ISBN | : 9783540205661 |
K.N. Houk, D.J. Tantillo, C. Stanton, Y. Hu: What Has Theory and Crystallography Revealed About the Mechanism of Catalysis by Orotidine Monophosphate Decarboxylase?N. Wu, E.F. Pai: Crystallographic Studies of Native and Mutant Orotidine 5'Phosphate Decarboxylases; B.G.
| Author | : David Whitford |
| Publisher | : John Wiley & Sons |
| Total Pages | : 544 |
| Release | : 2013-04-25 |
| Genre | : Science |
| ISBN | : 1118685725 |
Proteins: Structure and Function is a comprehensive introduction to the study of proteins and their importance to modern biochemistry. Each chapter addresses the structure and function of proteins with a definitive theme designed to enhance student understanding. Opening with a brief historical overview of the subject the book moves on to discuss the ‘building blocks’ of proteins and their respective chemical and physical properties. Later chapters explore experimental and computational methods of comparing proteins, methods of protein purification and protein folding and stability. The latest developments in the field are included and key concepts introduced in a user-friendly way to ensure that students are able to grasp the essentials before moving on to more advanced study and analysis of proteins. An invaluable resource for students of Biochemistry, Molecular Biology, Medicine and Chemistry providing a modern approach to the subject of Proteins.
| Author | : Graham L. Patrick |
| Publisher | : Elsevier |
| Total Pages | : 624 |
| Release | : 2020-05-30 |
| Genre | : Science |
| ISBN | : 0081012411 |
Antimalarial Agents: Design and Mechanism of Action seeks to support medicinal chemists in their work toward antimalarial solutions, providing practical guidance on past and current developments and highlighting promising leads for the future. Malaria is a deadly disease which threatens half of the world’s population. Advances over several decades have seen vast improvements in the eff ectiveness of both preventative measures and treatments, but the rapid adaptability of the disease means that the ongoing search for improved and novel antimalarial drugs is essential. Beginning with a historical overview of malaria and antimalarial research, this book goes on to describe the biological aspects of malaria, highlighting the lifecycle of the parasite responsible for malaria, the problem of resistance, genetic mapping of the parasite’s genome, established drug targets, and potential drug targets for the future. This sets the scene for the following chapters which provide a detailed study of the medicinal chemistry of antimalarial agents, with a focus on the design of antimalarial drugs. Drawing on the knowledge of its experienced authors, and coupling historic research with current fi ndings to provide a full picture of both past and current milestones, Antimalarial Agents: Design and Mechanism of Action is a comprehensive yet accessible guide for all those involved in the design, development, and administration of antimalarial drugs, including student academic researchers, medicinal chemists, malaria researchers, and pharmaceutical scientists. Consolidates both past and current developments in the discovery and design of antimalarial drugs Presents content in a style that is both thorough and engaging, providing a supportive and guiding reference to students and researchers from interdisciplinary backgrounds Highlights drug targets currently considered to be the most promising for future therapies, and the classes of compounds that are currently being studied and perfected
| Author | : Arieh Warshel |
| Publisher | : Wiley-Interscience |
| Total Pages | : 0 |
| Release | : 1997-03-28 |
| Genre | : Science |
| ISBN | : 9780471184409 |
This practical reference explores computer modeling of enzyme reations--techniques that help chemists, biochemists and pharmaceutical researchers understand drug and enzyme action.
| Author | : Craig Chenery |
| Publisher | : |
| Total Pages | : 500 |
| Release | : 2014-05-06 |
| Genre | : |
| ISBN | : 9781482314823 |
"Blood Splatter: A Guide to Cinematic Zombie Violence, Gore and Special Effects" by Craig W. Chenery is an in depth look at how gore and special effects have influenced and defined the zombie genre. Inside you will find: An exhaustive look at over 300 zombie films including detailed criteria such as body count, zombie count, amount of gore and effects quality. Almost 5,500 gory effects shots have been highlighted. Every bite, headshot and disembowelment has been listed enabling the viewer to easily locate the best in zombie gore. Thirty five exclusive interviews with the professionals who work behind the scenes to create them. TOM SAVINI (Dawn of the Dead), GREG NICOTERO (The Walking Dead, Land of the Dead), JOHN RUSSO (Night of the Living Dead), LLOYD KAUFMAN (CEO of Troma Entertainment) TOBY SELLS (The Crazies, Dance of the Dead, Zombieland), JOHN VULICH (Night of the Living Dead 1990), EVERETT BURRELL (Night of the Living Dead 1990), MARC PRICE (Colin), TONY GARDNER (Return of the Living Dead, Zombieland), STUART CONRAN (Shaun of the Dead) and many, many more discuss their techniques and adventures behind the camera. Over 300 rare and never before published behind the scenes photographs and production sketches. An in depth journal documenting the entire makeup process from life casting to application from one of Hollywood's leading SFX artists. What the critics are saying: "A great work; the kind of book that will appeal to serious scholars and casual fans alike. A must have." - Fangoria Magazine - Issue 312 "Completely satisfying. There's plenty to love here, enough to sate the most bloodthirsty ghouls. A coffee table book for those who love zombie movie make-up, it comes recommended. Four Stars". - Dread Central "Without question- this is THE definitive guide to the cinematic zombie genre. An absolute must-read! - Stiff Magazine "Bloodsplatter" is a gore slashed tome full of challenging analysis, body counts, and zombie stats that scores high in Mr. Lobo's book!" - Mr.Lobo, Cinema Insomnia, TV Horror Host "And just when you think you have seen it all - bam! - you get something like Blood Splatter on your plate!" "A fascinating book about zombies at the movies, and everything that goes into them". - Bricks of the Dead "Exhaustive as hell. I recommend Blood Splatter to anyone interested in the artistry involved in makeup effects, the nerdy minutia of zombie movie trivia, and rabid horror fans." - Cinema Sewer
| Author | : |
| Publisher | : |
| Total Pages | : 80 |
| Release | : 1912 |
| Genre | : Digestion |
| ISBN | : |
| Author | : Brett McLaughlin |
| Publisher | : "O'Reilly Media, Inc." |
| Total Pages | : 26 |
| Release | : 2011-07-13 |
| Genre | : Computers |
| ISBN | : 1449314481 |
Node.js. It’s the latest in a long line of “Are you cool enough to use me?” programming languages, APIs, and toolkits. In that sense, it lands squarely in the tradition of Rails, and Ajax, and Hadoop, and even to some degree iPhone programming and HTML5. Dig a little deeper, and you’ll hear that Node.js (or, as it’s more briefly called by many, simply “Node”) is a server-side solution for JavaScript, and in particular, for receiving and responding to HTTP requests. If that doesn’t completely boggle your mind, by the time the conversation heats up with discussion of ports, sockets, and threads, you’ll tend to glaze over. Is this really JavaScript? In fact, why in the world would anyone want to run JavaScript outside of a browser, let alone the server? The good news is that you’re hearing (and thinking) about the right things. Node really is concerned with network programming and server-side request/response processing. The bad news is that like Rails, Ajax, and Hadoop before it, there’s precious little clear information available. There will be, in time — as there now is for these other “cool” frameworks that have matured — but why wait for a book or tutorial when you might be able to use Node today, and dramatically improve the maintainability.
| Author | : Chuang Lu |
| Publisher | : John Wiley & Sons |
| Total Pages | : 878 |
| Release | : 2010-01-26 |
| Genre | : Medical |
| ISBN | : 0470538945 |
The science and applied approaches of enzyme inhibition in drug discovery and development Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development. With chapters written by over fifty leading experts in their fields, Enzyme Inhibition in Drug Discovery and Development fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the "good" inhibitions—desirable pharmacological effects—and "bad" inhibitions—drug–drug interactions and toxicity. The book discusses: The drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment The manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug–drug interactions The inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathway Through this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.
| Author | : Rodolfo Paoletti |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 530 |
| Release | : 2013-03-09 |
| Genre | : Medical |
| ISBN | : 146847796X |
The circulatory system is usually considered to be composed of tubes of various diameters, characterized by collateral and terminal branches. There is also a tendency to treat blood vessels merely as conducting tubes in which the various structures of the wall act as mechanical pumps wlrich modify their diameter. This is, of course, not so. In fact, we know that blood vessels, and in particular arteries, are organs with personalities of their own and a particular susceptibility to several diseases. In addition, blood vessels differ in structure, according to their localization, and age at differing rates. The experimental work car ried out so far clearly confirms the data that have come from spontaneous human pathology; experimentally induced arterial lesions have a definite tendency to appear in certain arteries and not in others, depending on the experimental procedures used, and in each specific artery the lesions appear to have a specific location. We now know that the arterial wall is a metabo licallyactive structure, in which a number of enzyme activities have been clearly demonstrated. It possesses a sensitive vasa vasorum apparatus and a specific reactivity to various lesion-inducing stimuli. We must also remember that the arterial wall is in continuous contact with the blood circulating through the endothelial cells lining the vascular bed. It is obvious, therefore, that any variation in the circulating blood mass can modify the morphology as well as the function of the vessel wall.
